Symptom-based subtypes of depression and their psychosocial correlates: A person-centered approach focusing on the influence of sex

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorRODGERS, Stephanie
dc.contributor.authorHOLTFORTH, Martin Grosse
dc.contributor.authorMUELLER, Mario
dc.contributor.authorHENGARTNER, Michael P.
dc.contributor.authorROESSLER, Wulf
dc.contributor.authorAJDACIC-GROSS, Vladeta
dc.date.accessioned2014-09-30T14:46:31Z
dc.date.available2014-09-30T14:46:31Z
dc.date.issued2014
dc.description.abstractBackground: Reducing the complexity of major depressive disorder by symptom-based subtypes constitutes the basis of more specific treatments. To date, few studies have empirically derived symptom subtypes separated by sex, although the impact of sex has been widely accepted in depression research. Methods: The community-based sample included 373 males and 443 females from the Zurich Program for Sustainable Development of Mental Health Services (ZInEP) manifesting depressive symptoms in the past 12 months. Latent Class Analysis ([CA) was performed separately by sex to extract sex-related depression subtypes. The subtypes were characterized by psychosocial characteristics. Results: Three similar subtypes were found in both sexes: a severe typical subtype (males: 22.8%; females: 35.7%), a severe atypical subtype (males: 17.4%; females: 22.6%), and a moderate subtype (males: 25.2%; females: 41.8%). In males, two additional subgroups were identified: a severe irritable/angry-rejection sensitive (IARS) subtype (30%) comprising the largest group, and a small psychomotor retarded subtype (4%). Males belonging to the severe typical subtype exhibited the lowest masculine gender role orientation, while females of the typical subtype showed more anxiety disorders. The severe atypical subtype was associated with eating disorders in both sexes and with alcohol/drug abuse/dependence in females. In contrast, alcohol/drug abuse/dependence was associated with the severe IARS subtype in males. Limitations: The study had a cross-sectional design, allowing for no causal inferences. Conclusions: This study contributes to a better understanding of sex-related depression subtypes, which can be well distinguished on the basis of symptom profiles. This provides the base for future research investigating the etiopathogenesis and effective treatment of the heterogeneous depression disorder.
dc.description.indexMEDLINE
dc.description.sponsorshipSwiss National Science Foundation (SNSF) [PP00P1-123377/1]
dc.identifier.citationJOURNAL OF AFFECTIVE DISORDERS, v.156, p.92-103, 2014
dc.identifier.doi10.1016/j.jad.2013.11.021
dc.identifier.eissn1573-2517
dc.identifier.issn0165-0327
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/7734
dc.language.isoeng
dc.publisherELSEVIER SCIENCE BV
dc.relation.ispartofJournal of Affective Disorders
dc.rightsrestrictedAccess
dc.rights.holderCopyright ELSEVIER SCIENCE BV
dc.subjectDepression
dc.subjectSubtypes
dc.subjectSex
dc.subjectEpidemiology
dc.subjectLatent class analysis
dc.subject.othernational-comorbidity-survey
dc.subject.otherlatent class analysis
dc.subject.otheradp-iv questionnaire
dc.subject.othergender-differences
dc.subject.otheratypical depression
dc.subject.othermajor depression
dc.subject.otherpsychiatric-disorders
dc.subject.otheranxious depression
dc.subject.othergeneral-population
dc.subject.otherclinical-features
dc.subject.wosClinical Neurology
dc.subject.wosPsychiatry
dc.titleSymptom-based subtypes of depression and their psychosocial correlates: A person-centered approach focusing on the influence of sex
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.affiliation.countrySuíça
hcfmusp.affiliation.countryisoch
hcfmusp.author.externalRODGERS, Stephanie:Zurich Univ Hosp Psychiat, Dept Psychiat Psychotherapy & Psychosomat, CH-8021 Zurich, Switzerland
hcfmusp.author.externalHOLTFORTH, Martin Grosse:Univ Zurich, Dept Psychol, CH-8006 Zurich, Switzerland; Univ Bern, Dept Psychol, CH-3012 Bern, Switzerland
hcfmusp.author.externalMUELLER, Mario:Zurich Univ Hosp Psychiat, Dept Psychiat Psychotherapy & Psychosomat, CH-8021 Zurich, Switzerland
hcfmusp.author.externalHENGARTNER, Michael P.:Zurich Univ Hosp Psychiat, Dept Psychiat Psychotherapy & Psychosomat, CH-8021 Zurich, Switzerland
hcfmusp.author.externalAJDACIC-GROSS, Vladeta:Zurich Univ Hosp Psychiat, Dept Psychiat Psychotherapy & Psychosomat, CH-8021 Zurich, Switzerland
hcfmusp.citation.scopus55
hcfmusp.description.beginpage92
hcfmusp.description.endpage103
hcfmusp.description.volume156
hcfmusp.origemWOS
hcfmusp.origem.pubmed24373526
hcfmusp.origem.scopus2-s2.0-84895064237
hcfmusp.origem.wosWOS:000330215700011
hcfmusp.publisher.cityAMSTERDAM
hcfmusp.publisher.countryNETHERLANDS
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