Homocysteine is associated with higher risks of ischemic stroke: A systematic review and meta-analysis

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorRABELO, Nicollas Nunes
dc.contributor.authorTELLES, Joao Paulo Mota
dc.contributor.authorPIPEK, Leonardo Zumerkorn
dc.contributor.authorNASCIMENTO, Rafaela Farias Vidigal
dc.contributor.authorGUSMAO, Rodrigo Coimbra de
dc.contributor.authorTEIXEIRA, Manoel Jacobsen
dc.contributor.authorFIGUEIREDO, Eberval Gadelha
dc.date.accessioned2023-04-14T17:56:56Z
dc.date.available2023-04-14T17:56:56Z
dc.date.issued2022
dc.description.abstractBackground High levels of homocysteine (Hct) have been associated with great risks of ischemic stroke. However, some controversy still exists. We performed a systematic review and meta-analysis to compare the levels of Hct between patients with ischemic stroke and controls. Methods We performed a systematic literature search for articles reporting Hct levels of patients with occurrence of ischemic stroke. We employed a random-effects inverse-variance weighted meta-analytical approach in order to pool standardized mean differences, with estimation of tau(2) through the DerSimonian-Laird method. Results The initial search yielded 1361 studies. After careful analysis of abstracts and full texts, the meta-analysis included data from 38 studies, which involved almost 16 000 stroke events. However, only 13 studies reported means and standard deviations for cases and controls, and therefore were used in the meta-analysis. Those studies presented data from 5002 patients with stroke and 4945 controls. Standardized mean difference was 1.67 (95% CI 1.00-2.25, P < 0.01), indicating that Hct levels were significantly larger in patients with ischemic stroke compared to controls. Between-study heterogeneity was very large (I-2 = 99%), particularly because three studies showed significantly large mean differences. Conclusion This meta-analysis shows that patients with ischemic stroke have higher levels of Hct compared to controls. Whether this is a modifiable risk factor remains to be assessed through larger prospective cohorts.eng
dc.description.indexMEDLINE
dc.description.indexPubMed
dc.description.indexWoS
dc.description.indexScopus
dc.identifier.citationPLOS ONE, v.17, n.10, article ID e0276087, 20p, 2022
dc.identifier.doi10.1371/journal.pone.0276087
dc.identifier.issn1932-6203
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/52986
dc.language.isoeng
dc.publisherPUBLIC LIBRARY SCIENCEeng
dc.relation.ispartofPlos One
dc.rightsopenAccesseng
dc.rights.holderCopyright PUBLIC LIBRARY SCIENCEeng
dc.subject.otherelevated plasma homocysteineeng
dc.subject.otherabdominal aortic-aneurysmeng
dc.subject.othercoronary-heart-diseaseeng
dc.subject.otherpoststroke depressioneng
dc.subject.othermyocardial-infarctioneng
dc.subject.otherhemorrhagic strokeeng
dc.subject.othervascular-diseaseeng
dc.subject.otherserum-levelseng
dc.subject.otherleveleng
dc.subject.otherhyperhomocysteinemiaeng
dc.subject.wosMultidisciplinary Scienceseng
dc.titleHomocysteine is associated with higher risks of ischemic stroke: A systematic review and meta-analysiseng
dc.typearticleeng
dc.type.categoryrevieweng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalNASCIMENTO, Rafaela Farias Vidigal:Ctr Univ Saude ABC, Fac Med ABC, Santo Andre, SP, Brazil
hcfmusp.citation.scopus12
hcfmusp.contributor.author-fmusphcNICOLLAS NUNES RABELO
hcfmusp.contributor.author-fmusphcJOAO PAULO MOTA TELLES
hcfmusp.contributor.author-fmusphcLEONARDO ZUMERKORN PIPEK
hcfmusp.contributor.author-fmusphcRODRIGO COIMBRA DE GUSMAO
hcfmusp.contributor.author-fmusphcMANOEL JACOBSEN TEIXEIRA
hcfmusp.contributor.author-fmusphcEBERVAL GADELHA FIGUEIREDO
hcfmusp.description.articlenumbere0276087
hcfmusp.description.issue10
hcfmusp.description.volume17
hcfmusp.origemWOS
hcfmusp.origem.scopus2-s2.0-85140144849
hcfmusp.origem.wosWOS:000924819300105
hcfmusp.publisher.citySAN FRANCISCOeng
hcfmusp.publisher.countryUSAeng
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