Variants inHSD11B1gene modulate susceptibility to diabetes kidney disease and to insulin resistance in type 1 diabetes

Página do item simplificado
dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorMORI, Rosana Cristina
dc.contributor.authorSANTOS-BEZERRA, Daniele Pereira
dc.contributor.authorPELAES, Tatiana Souza
dc.contributor.authorADMONI, Sharon Nina
dc.contributor.authorPEREZ, Ricardo Vessoni
dc.contributor.authorMONTEIRO, Maria Beatriz
dc.contributor.authorMACHADO, Cleide Guimaraes
dc.contributor.authorQUEIROZ, Marcia Silva
dc.contributor.authorMACHADO, Ubiratan Fabres
dc.contributor.authorCORREA-GIANNELLA, Maria Lucia
dc.date.accessioned2021-02-18T13:47:17Z
dc.date.available2021-02-18T13:47:17Z
dc.date.issued2021
dc.description.abstractBackground and aim 11 beta-Hydroxysteroid dehydrogenase 1 has been implicated in insulin resistance (IR) in the setting of metabolic disorders, and single nucleotide polymorphisms (SNPs) in its encoding gene (HSD11B1) have been associated with type 2 diabetes and metabolic syndrome. In type 1 diabetes (T1D), IR has been related to the development of chronic complications. We investigated the association ofHSD11B1SNPs with microvascular complications and with IR in a Brazilian cohort of T1D individuals. Materials and methods Five SNPs were genotyped in 466 T1D individuals (57% women; median of 37 years old, diabetes duration of 25 years and HbA1c of 8.4%). Results The minor allele T of rs11799643 was nominally associated with diabetic retinopathy (OR = 0.52; confidence interval [CI] 95% = 0.28-0.96;P= .036). The minor allele C of rs17389016 was nominally associated with overt diabetic kidney disease (DKD) (OR = 1.90; CI 95% = 1.07-3.37;P= .028). A follow-up study revealed that 29% of the individuals lost >= 5 mL min(-1)x 1.73 m(2)per year of the estimated glomerular filtration rate (eGFR). In these individuals (eGFR decliners), C allele of rs17389016 was more frequent than in non-decliners (OR = 2.10; CI 95% = 1.14-3.89;P= .018). Finally, minor allele T of rs846906 associated with higher prevalence of arterial hypertension, higher body mass index and waist circumference, thus conferring risk to a lower estimated glucose disposal rate, a surrogate marker of insulin sensitivity (OR = 1.23; CI 95% = 1.06-1.42;P= .004). Conclusion SNPs in theHSD11B1gene may confer susceptibility to DKD and to IR in T1D individuals.eng
dc.description.indexMEDLINEeng
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel SuperiorCAPES [001]
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao PauloFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2016/15603-0]
dc.identifier.citationDIABETES-METABOLISM RESEARCH AND REVIEWS, v.37, n.1, article ID e3352, 9p, 2021
dc.identifier.doi10.1002/dmrr.3352
dc.identifier.eissn1520-7560
dc.identifier.issn1520-7552
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/39435
dc.language.isoeng
dc.publisherWILEYeng
dc.relation.ispartofDiabetes-Metabolism Research and Reviews
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright WILEYeng
dc.subjectdiabetic microvascular complicationseng
dc.subjectestimated glomerular filtration rate (eGFR)eng
dc.subjectestimated glucose disposal rate (eGDR)eng
dc.subjectrs17389016eng
dc.subjectrs846906eng
dc.subjectsingle nucleotide polymorphism (SNP)eng
dc.subject.other11-beta-hydroxysteroid dehydrogenase type-1eng
dc.subject.othermetabolic syndromeeng
dc.subject.othergene polymorphismseng
dc.subject.otherglomerular-filtrationeng
dc.subject.othergenomic ancestryeng
dc.subject.otherassociationeng
dc.subject.othercomplicationseng
dc.subject.otherexpressioneng
dc.subject.otherobesityeng
dc.subject.other11-beta-hsd1eng
dc.subject.wosEndocrinology & Metabolismeng
dc.titleVariants inHSD11B1gene modulate susceptibility to diabetes kidney disease and to insulin resistance in type 1 diabeteseng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalMORI, Rosana Cristina:Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Ave Prof Lineu Prestes 1524, BR-05508900 Sao Paulo, Brazil
hcfmusp.author.externalPEREZ, Ricardo Vessoni:Univ Sao Paulo, Hosp Clin HCFMUSP, Lab Carboidratos & Radioimunoensaios LIM 18, Fac Med, Sao Paulo, Brazil
hcfmusp.author.externalMACHADO, Ubiratan Fabres:Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Ave Prof Lineu Prestes 1524, BR-05508900 Sao Paulo, Brazil
hcfmusp.citation.scopus7
hcfmusp.contributor.author-fmusphcDANIELE PEREIRA DOS SANTOS BEZERRA
hcfmusp.contributor.author-fmusphcTATIANA SOUZA PELAES
hcfmusp.contributor.author-fmusphcSHARON NINA ADMONI
hcfmusp.contributor.author-fmusphcMARIA BEATRIZ CAMARGO MONTEIRO CAILLAUD
hcfmusp.contributor.author-fmusphcCLEIDE GUIMARAES MACHADO CARANI
hcfmusp.contributor.author-fmusphcMARCIA SILVA QUEIROZ
hcfmusp.contributor.author-fmusphcMARIA LUCIA CARDILLO CORREA GIANNELLA
hcfmusp.description.articlenumbere3352
hcfmusp.description.issue1
hcfmusp.description.volume37
hcfmusp.origemWOS
hcfmusp.origem.pubmed32453474
hcfmusp.origem.scopus2-s2.0-85087212103
hcfmusp.origem.wosWOS:000541435200001
hcfmusp.publisher.cityHOBOKENeng
hcfmusp.publisher.countryUSAeng
hcfmusp.relation.referenceAndrews CA, 2010, NATURE ED KNOWL, V3, P65eng
hcfmusp.relation.referenceBarat P, 2013, DIABETES METAB, V39, P163, DOI 10.1016/j.diabet.2012.10.001eng
hcfmusp.relation.referenceBjornstad P, 2015, WORLD J DIABETES, V6, P8, DOI 10.4239/wjd.v6.i1.8eng
hcfmusp.relation.referenceChapman K, 2013, PHYSIOL REV, V93, P1139, DOI 10.1152/physrev.00020.2012eng
hcfmusp.relation.referenceChiodini I, 2007, DIABETES CARE, V30, P83, DOI 10.2337/dc06-1267eng
hcfmusp.relation.referenceDanielson KK, 2010, DIABETES CARE, V33, P614, DOI 10.2337/dc09-1220eng
hcfmusp.relation.referenceDevang N, 2017, DIABETES RES CLIN PR, V131, P142, DOI 10.1016/j.diabres.2017.07.011eng
hcfmusp.relation.referenceDraper N, 2005, J ENDOCRINOL, V186, P251, DOI 10.1677/joe.1.06019eng
hcfmusp.relation.referenceDujic T, 2012, BIOCHEM MEDICA, V22, P76eng
hcfmusp.relation.referenceDuran-Gonzalez J, 2011, ARCH MED RES, V42, P523, DOI 10.1016/j.arcmed.2011.10.010eng
hcfmusp.relation.referenceFeldman K, 2012, STEROIDS, V77, P1345, DOI 10.1016/j.steroids.2012.08.014eng
hcfmusp.relation.referenceGambineri A, 2011, EUR J ENDOCRINOL, V165, P283, DOI 10.1530/EJE-11-0091eng
hcfmusp.relation.referenceGandhi K, 2013, METAB SYNDR RELAT D, V11, P397, DOI 10.1089/met.2013.0049eng
hcfmusp.relation.referenceGathercole LL, 2010, J STEROID BIOCHEM, V122, P21, DOI 10.1016/j.jsbmb.2010.03.060eng
hcfmusp.relation.referenceGong R, 2008, LIFE SCI, V82, P631, DOI 10.1016/j.lfs.2007.12.019eng
hcfmusp.relation.referenceGrolmusz VK, 2014, MOL BIOL REP, V41, P5961, DOI 10.1007/s11033-014-3473-2eng
hcfmusp.relation.referenceHejduk Paulina, 2015, Postepy Hig Med Dosw (Online), V69, P1245eng
hcfmusp.relation.referenceHunter RW, 2015, CURR OPIN PHARMACOL, V21, P105, DOI 10.1016/j.coph.2015.01.005eng
hcfmusp.relation.referenceKilpatrick ES, 2007, DIABETES CARE, V30, P707, DOI 10.2337/dc06-1982eng
hcfmusp.relation.referenceKrolewski AS, 2017, KIDNEY INT, V91, P1300, DOI 10.1016/j.kint.2016.10.046eng
hcfmusp.relation.referenceLAHIRI DK, 1991, NUCLEIC ACIDS RES, V19, P5444, DOI 10.1093/nar/19.19.5444eng
hcfmusp.relation.referenceLevey AS, 2009, ANN INTERN MED, V150, P604, DOI 10.7326/0003-4819-150-9-200905050-00006eng
hcfmusp.relation.referenceLutz SZ, 2016, J CLIN ENDOCR METAB, V101, P4743, DOI 10.1210/jc.2016-2498eng
hcfmusp.relation.referenceMontasser ME, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0092468eng
hcfmusp.relation.referenceMonteiro MB, 2016, FREE RADICAL RES, V50, P101, DOI 10.3109/10715762.2015.1109083eng
hcfmusp.relation.referenceNair S, 2004, DIABETOLOGIA, V47, P1088, DOI 10.1007/s00125-004-1407-6eng
hcfmusp.relation.referenceOrchard TJ, 2002, KIDNEY INT, V62, P963, DOI 10.1046/j.1523-1755.2002.00507.xeng
hcfmusp.relation.referencePena SDJ, 2009, BRAZ J MED BIOL RES, V42, P870, DOI 10.1590/S0100-879X2009005000026eng
hcfmusp.relation.referencePimenta JR, 2006, HUM HERED, V62, P190, DOI 10.1159/000096872eng
hcfmusp.relation.referencePop A, 2016, J DIABETES, V8, P220, DOI 10.1111/1753-0407.12283eng
hcfmusp.relation.referenceQuteineh L, 2015, PHARMACOGENET GENOM, V25, P246, DOI 10.1097/FPC.0000000000000131eng
hcfmusp.relation.referenceSantos-Bezerra DP, 2018, DIABETES VASC DIS RE, V15, P81, DOI 10.1177/1479164117733918eng
hcfmusp.relation.referenceSimunkova K, 2011, PHYSIOL RES, V60, P263, DOI 10.33549/physiolres.932079eng
hcfmusp.relation.referenceSTEWART PM, 1994, J CLIN ENDOCR METAB, V79, P480, DOI 10.1210/jc.79.2.480eng
hcfmusp.relation.referenceStomby A, 2014, DIABETOLOGIA, V57, P1100, DOI 10.1007/s00125-014-3228-6eng
hcfmusp.relation.referenceSvensson M, 2002, EUR J CLIN INVEST, V32, P100, DOI 10.1046/j.1365-2362.2002.00949.xeng
hcfmusp.relation.referenceTomlinson JW, 2001, BEST PRACT RES CL EN, V15, P61, DOI 10.1053/beem.2000.0119eng
hcfmusp.relation.referenceTurek LV, 2014, GENET MOL BIOL, V37, P490, DOI 10.1590/S1415-47572014000400003eng
hcfmusp.relation.referenceWilkinson CP, 2003, OPHTHALMOLOGY, V110, P1677, DOI 10.1016/S0161-6420(03)00475-5eng
hcfmusp.relation.referenceWilliams KV, 2000, DIABETES, V49, P626, DOI 10.2337/diabetes.49.4.626eng
hcfmusp.scopus.lastupdate2024-05-10
relation.isAuthorOfPublication04b2d727-2bd6-469a-8d07-029d5bcf8d71
relation.isAuthorOfPublication0ad56e25-b661-4e5a-9a8f-1b177356021b
relation.isAuthorOfPublication978f0307-9353-4ade-8202-4e566d38b896
relation.isAuthorOfPublication595dcd98-4ca3-48b0-b904-063270ca9023
relation.isAuthorOfPublication01eced4a-acb6-4768-90eb-92e8816ddc01
relation.isAuthorOfPublication8f247733-75be-483d-a874-c2bdcd507ff9
relation.isAuthorOfPublicationa816ae7a-8943-42d1-81f4-eeb39f544483
relation.isAuthorOfPublication.latestForDiscovery04b2d727-2bd6-469a-8d07-029d5bcf8d71
Arquivos
Pacote Original
Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
art_MORI_Variants_inHSD11B1gene_modulate_susceptibility_to_diabetes_kidney_disease_2021.PDF
Tamanho:
699.55 KB
Formato:
Adobe Portable Document Format
Descrição:
publishedVersion (English)
Baixar
Coleções
Artigos e Materiais de Revistas Científicas - FM/Outros
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/18
Artigos e Materiais de Revistas Científicas - ODS/03