Development of human minor salivary glands: expression of mucins according to stage of morphogenesis

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorTESHIMA, Tathyane H. N.
dc.contributor.authorIANEZ, Renata F.
dc.contributor.authorCOUTINHO-CAMILLO, Claudia M.
dc.contributor.authorBUIM, Marcilei E.
dc.contributor.authorSOARES, Fernando A.
dc.contributor.authorLOURENCO, Silvia V.
dc.date.accessioned2017-11-27T16:48:46Z
dc.date.available2017-11-27T16:48:46Z
dc.date.issued2011
dc.description.abstractThe formation of salivary glands entails the proliferation of epithelial cells from the stomatodeum into the underlying ectomesenchyme, culminating in a complex network of ducts and acinar bulbs. The extent to which mucins regulate this process is unknown, but they appear to mediate luminal space formation and maturation. Our aim was to examine mucin expression patterns during the morphogenesis of human salivary glands. Mucin expression - MUC1, 2, 3, 4, 5AC, 5B, 6, and 16 - was analyzed in specimens of developing human salivary glands, obtained from fetuses at 4-24 weeks' gestation, and fully developed salivary glands by immunohistochemistry. Expression patterns were analyzed qualitatively according to the development stage of the salivary glands. Mucins 1, 3, 4, 5B, and 16 were expressed during salivary gland development - being stronger in all ductal segments by the final phases of branching morphogenesis and in mature glands. Acinar cells were negative for most mucins, including MUC1 in mature salivary glands. Mucins 2, 5AC, and 6 were not expressed. Mucins MUC1, 3, 4, 5B, and 16 are expressed in developing human salivary glands and in mature glands, suggesting important roles in the maturation and maintenance of the ductal network.
dc.description.indexMEDLINE
dc.identifier.citationJOURNAL OF ANATOMY, v.219, n.3, p.410-417, 2011
dc.identifier.doi10.1111/j.1469-7580.2011.01405.x
dc.identifier.issn0021-8782
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/24049
dc.language.isoeng
dc.publisherWILEY-BLACKWELL
dc.relation.ispartofJournal of Anatomy
dc.rightsrestrictedAccess
dc.rights.holderCopyright WILEY-BLACKWELL
dc.subjectbranching morphogenesis
dc.subjecthuman salivary glands
dc.subjectmucin
dc.subject.othermembrane-associated mucins
dc.subject.otherparallel relation
dc.subject.otherepithelial mucin
dc.subject.othercell-surface
dc.subject.otherbound mucins
dc.subject.othermuc5ac
dc.subject.otherlocalization
dc.subject.othergenes
dc.subject.otherprotection
dc.subject.othersecretion
dc.subject.wosAnatomy & Morphology
dc.titleDevelopment of human minor salivary glands: expression of mucins according to stage of morphogenesis
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalIANEZ, Renata F.:AC Camargo Hosp, Dept Pathol, Sao Paulo, Brazil
hcfmusp.author.externalCOUTINHO-CAMILLO, Claudia M.:AC Camargo Hosp, Dept Pathol, Sao Paulo, Brazil
hcfmusp.author.externalBUIM, Marcilei E.:AC Camargo Hosp, Dept Pathol, Sao Paulo, Brazil
hcfmusp.author.externalSOARES, Fernando A.:AC Camargo Hosp, Dept Pathol, Sao Paulo, Brazil
hcfmusp.citation.scopus19
hcfmusp.contributor.author-fmusphcSILVIA VANESSA LOURENCO
hcfmusp.description.beginpage410
hcfmusp.description.endpage417
hcfmusp.description.issue3
hcfmusp.description.volume219
hcfmusp.origemWOS
hcfmusp.origem.pubmed21679184
hcfmusp.origem.scopus2-s2.0-79961009145
hcfmusp.origem.wosWOS:000293510600007
hcfmusp.publisher.cityMALDEN
hcfmusp.publisher.countryUSA
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