Outbreak of carbapenem-resistant Klebsiella pneumoniae: two-year epidemiologic follow-up in a tertiary hospital

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorPEREIRA, Graziella Hanna
dc.contributor.authorGARCIA, Doroti O.
dc.contributor.authorMOSTARDEIRO, Marcelo
dc.contributor.authorFANTI, Karina S. V. N.
dc.contributor.authorLEVIN, Anna S.
dc.date.accessioned2013-09-23T16:39:43Z
dc.date.available2013-09-23T16:39:43Z
dc.date.issued2013
dc.description.abstractThis study describes a carbapenem-resistant Klebsiella pneumoniae (CRKP) outbreak that occurred from October 2008-December 2010. Polymerase chain reaction assays were performed to detect the bla(KPC) gene and molecular typing was performed using pulsed-field gel electrophoresis (PFGE). There were 33 CRKP infections; PFGE revealed five genotypes: genotype A in five (15%), B in 18 (55%), C in eight (24%) and two unique profiles. Genotype B was disseminated in all hospital units and belonged to the same clone identified in 11 different hospitals in the state of Sao Paulo. Sixteen (48%) patients died. Seven isolates (21%) were resistant to polymyxin B and 45% were resistant to tigecycline and amikacin.
dc.description.indexMEDLINE
dc.description.sponsorshipFAPESP [2009/53229-0]
dc.identifier.citationMEMORIAS DO INSTITUTO OSWALDO CRUZ, v.108, n.1, p.113-115, 2013
dc.identifier.doi10.1590/S0074-02762013000100019
dc.identifier.issn0074-0276
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/1972
dc.language.isoeng
dc.publisherFUNDACO OSWALDO CRUZ
dc.relation.ispartofMemorias do Instituto Oswaldo Cruz
dc.rightsopenAccess
dc.rights.holderCopyright FUNDACO OSWALDO CRUZ
dc.subjectcarbapenem-resistant K. pneumoniae
dc.subjectnosocomial outbreak
dc.subjectpolymyxin resistance
dc.subject.otherfield gel-electrophoresis
dc.subject.otherbeta-lactamase
dc.subject.otherbrazil
dc.subject.otherinfection
dc.subject.wosParasitology
dc.subject.wosTropical Medicine
dc.titleOutbreak of carbapenem-resistant Klebsiella pneumoniae: two-year epidemiologic follow-up in a tertiary hospital
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalPEREIRA, Graziella Hanna:Hosp Brigadeiro, Dept Controle Infeccao, Sao Paulo, SP, Brazil
hcfmusp.author.externalGARCIA, Doroti O.:Adolfo Lutz Inst, Ctr Bacteriol, Sao Paulo, Brazil
hcfmusp.author.externalMOSTARDEIRO, Marcelo:Hosp Brigadeiro, Dept Controle Infeccao, Sao Paulo, SP, Brazil
hcfmusp.author.externalFANTI, Karina S. V. N.:Hosp Brigadeiro, Dept Controle Infeccao, Sao Paulo, SP, Brazil
hcfmusp.citation.scopus10
hcfmusp.contributor.author-fmusphcANNA SARA SHAFFERMAN LEVIN
hcfmusp.description.beginpage113
hcfmusp.description.endpage115
hcfmusp.description.issue1
hcfmusp.description.volume108
hcfmusp.origemWOS
hcfmusp.origem.pubmed23440125
hcfmusp.origem.scieloSCIELO:S0074-02762013000100019
hcfmusp.origem.scopus2-s2.0-84875467393
hcfmusp.origem.wosWOS:000315335800019
hcfmusp.publisher.cityRIO DE JANEIRO, RJ
hcfmusp.publisher.countryBRAZIL
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hcfmusp.remissive.sponsorshipFAPESP
hcfmusp.scopus.lastupdate2024-05-17
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Artigos e Materiais de Revistas Científicas - FM/MIP
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Artigos e Materiais de Revistas Científicas - LIM/54
Artigos e Materiais de Revistas Científicas - ODS/03