IN VITRO TRYPANOCIDAL EVALUATION OF PINANE DERIVATIVES FROM ESSENTIAL OILS OF RIPE FRUITS FROM Schinus terebinthifolius RADDI (ANACARDIACEAE)

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art_PINTO_IN_VITRO_TRYPANOCIDAL_EVALUATION_OF_PINANE_DERIVATIVES_FROM_2012.PDF (307.41 KB)
Citações na Scopus
19
Tipo de produção
article
Data de publicação
2012
DOI
Scopus
Web of Science
Título da Revista
ISSN da Revista
Título do Volume
Editora
SOC BRASILEIRA QUIMICA
Autores
SARTORELLI, Patricia
SANTANA, Jefferson S.
GUADAGNIN, Rafael C.
LAGO, Joao Henrique G.
TEMPONE, Andre G.
STEFANI, Helio A.
SOARES, Marisi G.
SILVA, Adalberto M. da
Citação
QUIMICA NOVA, v.35, n.4, p.743-747, 2012
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Essential oils of ripe fruits from Schinus terebinthifolius (Anacardiaceae), obtained using a pilot extractor and a Clevenger apparatus were chemically characterized. Due the high amount of (-)-alpha-pinene in both oils, this monoterpene was tested against the protozoan parasite Trypanosoma cruzi, showing a moderate potential (IC50 63.56 mu g/mL) when compared to benznidazole (IC50 43.14 mu g/mL). Otherwise, (-)-alpha-pinene oxide did not showed anti-trypanosomal activity (IC50 > 400 mu g/mL) while (-)-pinane showed an IC50 of 56.50 mu g/mL. The obtained results indicated that the epoxydation of a-pinene results to the loss of the anti-parasitic activity while its hydrogenation product, contributed slightly to the increased activity.
Palavras-chave
Schinus terebinthifolius Raddi, Anacardiaceae, trypanocidal activity
URI
https://observatorio.fm.usp.br/handle/OPI/1194
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Coleções
Artigos e Materiais de Revistas Científicas - IMT