Weight loss and improved mood after aerobic exercise training are linked to lower plasma anandamide in healthy people

Página do item simplificado
dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorOLIVEIRA, Ardo Belitardo de
dc.contributor.authorMELLO, Marco Tulio de
dc.contributor.authorTUFIK, Serio
dc.contributor.authorPERES, Mario Fernando Prieto
dc.date.accessioned2019-05-30T13:39:04Z
dc.date.available2019-05-30T13:39:04Z
dc.date.issued2019
dc.description.abstractAnandamide, a major endocannabinoid, participates in energy metabolism homeostasis and neurobehavioral processes. In a secondary analysis of an open-label, randomized controlled trial, we investigated the long-term effect of aerobic exercise on resting plasma anandamide, and explored its relationship with changes in body weight, cardiorespiratory fitness, and mood status in healthy, physically inactive individuals. Participants recruited between March 2013 to August 2015 at the UNIFESP's Neurology/Psychobiology Department were randomly allocated into a 12-weeks supervised moderate exercise program, or into waitlist, control condition. Thirty-four participants (age = 38 +/- 11.5, BMI = 26.6 +/- 3.6) were intention to treat-analysed (Exercise: n = 17; Control: n = 17). After intervention, there were significant decreases in plasma anandamide (p < .01), anger, anxiety, and body weight (all p < .05), whereas cardiorespiratory fitness increased (p < .05) in the exercise group. There were no significant changes in any variable for the control group. In the whole cohort, adjusted R-2 of multiple linear regressions showed that 12.2% of change body weight was explained by changes in anandamide (beta = 0.391, p = .033), while 27% of change in mood disturbance (beta= 0. 546, p = .003), and 13.1% of change in anger (beta = 0.404, p = .03) was explained by changes in anandamide. Our data suggest that the weight loss and mood improvement through regular moderate exercise may involve changes in anandamide metabolism/signaling.eng
dc.description.indexMEDLINEeng
dc.description.sponsorshipCoordenadoria de Aperfeicoamento de Pessoal de Nivel Superior - CAPES
dc.identifier.citationPHYSIOLOGY & BEHAVIOR, v.201, p.191-197, 2019
dc.identifier.doi10.1016/j.physbeh.2018.12.018
dc.identifier.issn0031-9384
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/31836
dc.language.isoeng
dc.publisherPERGAMON-ELSEVIER SCIENCE LTDeng
dc.relation.ispartofPhysiology & Behavior
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright PERGAMON-ELSEVIER SCIENCE LTDeng
dc.subjectEndocannabinoidseng
dc.subjectWeight losseng
dc.subjectPhysical activityeng
dc.subjectExerciseeng
dc.subjectMental Healtheng
dc.subjectPeak Oxygen Uptakeeng
dc.subject.otherendocannabinoid systemeng
dc.subject.otherskeletal-muscleeng
dc.subject.otherenergy homeostasiseng
dc.subject.otherstresseng
dc.subject.otheractivationeng
dc.subject.otherstatementeng
dc.subject.otherresponseseng
dc.subject.otherhumanseng
dc.subject.otheradultseng
dc.subject.wosPsychology, Biologicaleng
dc.subject.wosBehavioral Scienceseng
dc.titleWeight loss and improved mood after aerobic exercise training are linked to lower plasma anandamide in healthy peopleeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalOLIVEIRA, Ardo Belitardo de:Univ Fed Sao Paulo, Dept Neurol & Neurosurg, 669 Pedro Toledo, BR-04039032 Sao Paulo, Brazil
hcfmusp.author.externalMELLO, Marco Tulio de:Univ Fed Minas Gerais, Dept Sports Sci, 6627 Pres Antonio Carlos Av, BR-31270901 Belo Horizonte, MG, Brazil
hcfmusp.author.externalTUFIK, Serio:Univ Fed Sao Paulo, Dept Psychobiol, 862 Botucatu, BR-04032030 Sao Paulo, SP, Brazil
hcfmusp.citation.scopus11
hcfmusp.contributor.author-fmusphcMARIO FERNANDO PRIETO PERES
hcfmusp.description.beginpage191
hcfmusp.description.endpage197
hcfmusp.description.volume201
hcfmusp.origemWOS
hcfmusp.origem.pubmed30578894
hcfmusp.origem.scopus2-s2.0-85060302049
hcfmusp.origem.wosWOS:000460824400023
hcfmusp.publisher.cityOXFORDeng
hcfmusp.publisher.countryENGLANDeng
hcfmusp.relation.referenceAddy C, 2008, CELL METAB, V7, P68, DOI 10.1016/j.cmet.2007.11.012eng
hcfmusp.relation.referenceAguiar DC, 2014, NEUROSCI BIOBEHAV R, V46, P418, DOI 10.1016/j.neubiorev.2014.03.026eng
hcfmusp.relation.referenceBalady GJ, 2010, CIRCULATION, V122, P191, DOI 10.1161/CIR.0b013e3181e52e69eng
hcfmusp.relation.referenceBouaboula M, 2005, EUR J PHARMACOL, V517, P174, DOI 10.1016/j.ejphar.2005.05.032eng
hcfmusp.relation.referenceBoutron I, 2008, ANN INTERN MED, V148, P295, DOI 10.7326/0003-4819-148-4-200802190-00008eng
hcfmusp.relation.referenceBrellenthin AG, 2017, MED SCI SPORT EXER, V49, P1688, DOI 10.1249/MSS.0000000000001276eng
hcfmusp.relation.referenceCavuoto P, 2007, MOL CELL ENDOCRINOL, V267, P63, DOI 10.1016/j.mce.2006.12.038eng
hcfmusp.relation.referenceCrombie KM, 2018, J TRAUMA STRESS, V31, P134, DOI 10.1002/jts.22253eng
hcfmusp.relation.referenceCrosby KM, 2012, NEUROSCIENCE, V204, P31, DOI 10.1016/j.neuroscience.2011.11.049eng
hcfmusp.relation.referenceDi Marzo V, 2009, DIABETOLOGIA, V52, P213, DOI 10.1007/s00125-008-1178-6eng
hcfmusp.relation.referenceDietrich A, 2004, BRIT J SPORT MED, V38, P536, DOI 10.1136/bjsm.2004.011718eng
hcfmusp.relation.referencediTomaso E, 1996, NATURE, V382, P677, DOI 10.1038/382677a0eng
hcfmusp.relation.referenceDlugos A, 2012, NEUROPSYCHOPHARMACOL, V37, P2416, DOI 10.1038/npp.2012.100eng
hcfmusp.relation.referenceEngeli S, 2005, DIABETES, V54, P2838, DOI 10.2337/diabetes.54.10.2838eng
hcfmusp.relation.referenceEvans S, 2007, PLOS CLIN TRIALS, V2, P1, DOI 10.1371/journal.pctr.0020018eng
hcfmusp.relation.referenceGamelin FX, 2016, J PHYSIOL BIOCHEM, V72, P183, DOI 10.1007/s13105-016-0469-5eng
hcfmusp.relation.referenceGasperi V, 2014, MED SCI SPORT EXER, V46, P24, DOI 10.1249/MSS.0b013e3182a10ce6eng
hcfmusp.relation.referenceHaring M, 2012, NEUROSCIENCE, V204, P145, DOI 10.1016/j.neuroscience.2011.12.035eng
hcfmusp.relation.referenceHeyman E, 2012, OBES REV, V13, P1110, DOI 10.1111/j.1467-789X.2012.01026.xeng
hcfmusp.relation.referenceHeyman E, 2012, PSYCHONEUROENDOCRINO, V37, P844, DOI 10.1016/j.psyneuen.2011.09.017eng
hcfmusp.relation.referenceHill MN, 2012, NEUROSCIENCE, V204, P5, DOI 10.1016/j.neuroscience.2011.12.030eng
hcfmusp.relation.referenceHutchins-Wiese HL, 2012, J NUTR BIOCHEM, V23, P986, DOI 10.1016/j.jnutbio.2011.05.005eng
hcfmusp.relation.referenceKim J, 2011, NUTRITION, V27, P624, DOI 10.1016/j.nut.2010.11.003eng
hcfmusp.relation.referenceLear SA, 2017, LANCET, V390, P2643, DOI 10.1016/S0140-6736(17)31634-3eng
hcfmusp.relation.referenceLipina C, 2014, AM J PHYSIOL-ENDOC M, V307, pE1, DOI 10.1152/ajpendo.00100.2014eng
hcfmusp.relation.referenceLiu YL, 2005, INT J OBESITY, V29, P183, DOI 10.1038/sj.ijo.0802847eng
hcfmusp.relation.referenceMatias I, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0042399eng
hcfmusp.relation.referenceMcNair D., 1971, PROFILE MOOD STATES, P1eng
hcfmusp.relation.referenceMethoulam R., 2002, PROSTAGLANDINS LEUKO, V66, P93eng
hcfmusp.relation.referenceMicale V, 2013, PHARMACOL THERAPEUT, V138, P18, DOI 10.1016/j.pharmthera.2012.12.002eng
hcfmusp.relation.referenceAntunes HKM, 2016, PHYSIOL BEHAV, V156, P182, DOI 10.1016/j.physbeh.2016.01.028eng
hcfmusp.relation.referenceMoreira FA, 2012, NEUROSCIENCE, V204, P186, DOI 10.1016/j.neuroscience.2011.08.046eng
hcfmusp.relation.referenceOliveira AB, 2017, J NEUROIMMUNOL, V313, P138, DOI 10.1016/j.jneuroim.2017.09.008eng
hcfmusp.relation.referenceRaichlen DA, 2013, EUR J APPL PHYSIOL, V113, P869, DOI 10.1007/s00421-012-2495-5eng
hcfmusp.relation.referenceRaichlen DA, 2012, J EXP BIOL, V215, P1331, DOI 10.1242/jeb.063677eng
hcfmusp.relation.referenceSilvestri C, 2013, CELL METAB, V17, P475, DOI 10.1016/j.cmet.2013.03.001eng
hcfmusp.relation.referenceSparling PB, 2003, NEUROREPORT, V14, P2209, DOI 10.1097/01.wnr.0000097048.56589.47eng
hcfmusp.relation.referenceTantimonaco M, 2014, CELL MOL LIFE SCI, V71, P2681, DOI 10.1007/s00018-014-1575-6eng
hcfmusp.relation.referenceTaube A, 2009, AM J PHYSIOL-ENDOC M, V297, pE1004, DOI 10.1152/ajpendo.00241.2009eng
hcfmusp.relation.referenceWahid A, 2016, J AM HEART ASSOC, V5, DOI 10.1161/JAHA.115.002495eng
hcfmusp.relation.referenceZschucke Elisabeth, 2013, J Prev Med Public Health, V46 Suppl 1, pS12, DOI 10.3961/jpmph.2013.46.S.S12eng
hcfmusp.scopus.lastupdate2024-05-10
relation.isAuthorOfPublication6449c4c3-3828-43a3-ad3d-1c38a78a66d5
relation.isAuthorOfPublication.latestForDiscovery6449c4c3-3828-43a3-ad3d-1c38a78a66d5
Arquivos
Pacote Original
Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
art_OLIVEIRA_Weight_loss_and_improved_mood_after_aerobic_exercise_2019.PDF
Tamanho:
2.06 MB
Formato:
Adobe Portable Document Format
Descrição:
publishedVersion (English)
Baixar
Coleções
Artigos e Materiais de Revistas Científicas - FM/Outros
Artigos e Materiais de Revistas Científicas - LIM/21