Vaginal Microbiome Components as Correlates of Cervical Human Papillomavirus Infection

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorMORALES, Julia Andrade Pessoa
dc.contributor.authorMARCONI, Camila
dc.contributor.authorEL-ZEIN, Mariam
dc.contributor.authorRAVEL, Jacques
dc.contributor.authorPINTO, Gabriel Victor da Silva
dc.contributor.authorSILVEIRA, Rosana
dc.contributor.authorLIMA, Moises Diogo de
dc.contributor.authorCARVALHO, Newton Sergio de
dc.contributor.authorALVES, Rosane Ribeiro Figueiredo
dc.contributor.authorPARADA, Cristina Maria Garcia de Lima
dc.contributor.authorLEITE, Sandra Helena Morais
dc.contributor.authorVILLA, Luisa L.
dc.contributor.authorFRANCO, Eduardo L.
dc.contributor.authorSILVA, Marcia Guimaraes da
dc.date.accessioned2022-12-21T13:21:01Z
dc.date.available2022-12-21T13:21:01Z
dc.date.issued2022
dc.description.abstractBackground Interplay between vaginal microbiome and human papillomavirus (HPV) remains unclear, partly due to heterogeneity of microbiota. Methods We used data from 546 women enrolled in a cross-sectional study in 5 Brazil. We genotyped vaginal samples for HPV and sequenced V3-V4 region of 16S rRNA gene for vaginal microbiome analysis. We used stepwise logistic regression to construct 2 linear scores to predict high-risk HPV (hrHPV) positivity: one based exclusively on presence of individual bacterial taxa (microbiome-based [MB] score) and the other exclusively on participants' sociodemographic, behavioral, and clinical (SBC) characteristics. MB score combined coefficients of 30 (of 116) species. SBC score retained 6 of 25 candidate variables. We constructed receiver operating characteristic curves for scores as hrHPV correlates and compared areas under the curve (AUC) and 95% confidence intervals (CI). Results Overall, prevalence of hrHPV was 15.8%, and 26.2% had a Lactobacillus-depleted microbiome. AUCs were 0.8022 (95% CI, .7517-.8527) for MB score and 0.7027 (95% CI, .6419-.7636) for SBC score (P = .0163). Conclusions The proposed MB score is strongly correlated with hrHPV positivity-exceeding the predictive value of behavioral variables-suggesting its potential as an indicator of infection and possible value for clinical risk stratification. This cross-sectional study demonstrated a strong correlation between vaginal microbiome components and cervical high-risk HPV positivity.eng
dc.description.indexMEDLINEeng
dc.description.sponsorshipSao Paulo Research Foundation [2012/01278-0, 2012/16800-3, 2012/10403-2, 2018/18469-9]
dc.description.sponsorshipCancer Research Society
dc.identifier.citationJOURNAL OF INFECTIOUS DISEASES, v.226, n.6, p.1084-1097, 2022
dc.identifier.doi10.1093/infdis/jiab547
dc.identifier.eissn1537-6613
dc.identifier.issn0022-1899
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/50490
dc.language.isoeng
dc.publisherOXFORD UNIV PRESS INCeng
dc.relation.ispartofJournal of Infectious Diseases
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright OXFORD UNIV PRESS INCeng
dc.subjectvaginal microbiomeeng
dc.subjectHPV infectioneng
dc.subjecthigh-risk HPVeng
dc.subject16S RNA sequencingeng
dc.subject.otherbacterial vaginosiseng
dc.subject.otherreproductive-ageeng
dc.subject.otherchlamydial infectioneng
dc.subject.othersexual-behavioreng
dc.subject.otherhpv infectioneng
dc.subject.otherrisk-factorseng
dc.subject.otherwomeneng
dc.subject.othercancereng
dc.subject.wosImmunologyeng
dc.subject.wosInfectious Diseaseseng
dc.subject.wosMicrobiologyeng
dc.titleVaginal Microbiome Components as Correlates of Cervical Human Papillomavirus Infectioneng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryCanadá
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryisoca
hcfmusp.affiliation.countryisous
hcfmusp.author.externalMORALES, Julia Andrade Pessoa:Sao Paulo State Univ UNESP, Botucatu Med Sch, Dept Pathol, Botucatu, SP, Brazil
hcfmusp.author.externalMARCONI, Camila:Sao Paulo State Univ UNESP, Botucatu Med Sch, Dept Pathol, Botucatu, SP, Brazil; Univ Fed Parana, Dept Basic Pathol, Curitiba, Parana, Brazil
hcfmusp.author.externalEL-ZEIN, Mariam:McGill Univ, Div Canc Epidemiol, Montreal, PQ, Canada
hcfmusp.author.externalRAVEL, Jacques:Univ Maryland, Sch Med, Inst Genom Sci, Baltimore, MD 21201 USA
hcfmusp.author.externalPINTO, Gabriel Victor da Silva:Sao Paulo State Univ UNESP, Botucatu Med Sch, Dept Pathol, Botucatu, SP, Brazil
hcfmusp.author.externalSILVEIRA, Rosana:Sao Paulo State Univ UNESP, Botucatu Med Sch, Dept Pathol, Botucatu, SP, Brazil
hcfmusp.author.externalLIMA, Moises Diogo de:Fed Univ Paraiba UFPB, Dept Gynecol & Obstet, Joao Pessoa, Paraiba, Brazil
hcfmusp.author.externalCARVALHO, Newton Sergio de:Univ Fed Parana, Dept Basic Pathol, Curitiba, Parana, Brazil
hcfmusp.author.externalALVES, Rosane Ribeiro Figueiredo:Fed Univ Goias UFG, Dept Gynecol & Obstet, Goiania, Go, Brazil
hcfmusp.author.externalPARADA, Cristina Maria Garcia de Lima:Sao Paulo State Univ UNESP, Botucatu Med Sch, Dept Nursing, Botucatu, SP, Brazil
hcfmusp.author.externalLEITE, Sandra Helena Morais:State Univ Para, Dept Gynecol & Obstet, Belem, Para, Brazil
hcfmusp.author.externalFRANCO, Eduardo L.:McGill Univ, Div Canc Epidemiol, Montreal, PQ, Canada
hcfmusp.author.externalSILVA, Marcia Guimaraes da:Sao Paulo State Univ UNESP, Botucatu Med Sch, Dept Pathol, Botucatu, SP, Brazil
hcfmusp.citation.scopus7
hcfmusp.contributor.author-fmusphcLUISA LINA VILLA
hcfmusp.description.beginpage1084
hcfmusp.description.endpage1097
hcfmusp.description.issue6
hcfmusp.description.volume226
hcfmusp.origemWOS
hcfmusp.origem.pubmed34718662
hcfmusp.origem.scopus2-s2.0-85130220135
hcfmusp.origem.wosWOS:000790055600001
hcfmusp.publisher.cityCARYeng
hcfmusp.publisher.countryUSAeng
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