Tumor growth pattern as predictor of colorectal liver metastasis recurrence

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorPINHEIRO, Rafael S.
dc.contributor.authorHERMAN, Paulo
dc.contributor.authorLUPINACCI, Renato M.
dc.contributor.authorLAI, Quirino
dc.contributor.authorMELLO, Evandro S.
dc.contributor.authorCOELHO, Fabricio F.
dc.contributor.authorPERINI, Marcos V.
dc.contributor.authorPUGLIESE, Vincenzo
dc.contributor.authorANDRAUS, Wellington
dc.contributor.authorCECCONELLO, Ivan
dc.contributor.authorD'ALBUQUERQUE, Luiz Carneiro
dc.date.accessioned2014-09-30T14:40:56Z
dc.date.available2014-09-30T14:40:56Z
dc.date.issued2014
dc.description.abstractBACKGROUND: Surgical resection is the gold standard therapy for the treatment of colorectal liver metastases (CRM). The aim of this study was to investigate the impact of tumor growth patterns on disease recurrence. METHODS: We enrolled 91 patients who underwent CRM resection. Pathological specimens were prospectively evaluated, with particular attention given to tumor growth patterns (infiltrative vs pushing). RESULTS: Tumor recurrence was observed in 65 patients (71.4%). According to multivariate analysis, 3 or more lesions (P = .05) and the infiltrative tumor margin type (P = .05) were unique independent risk factors for recurrence. Patients with infiltrative margins had a 5-year disease-free survival rate significantly inferior to patients with pushing margins (20.2% vs 40.5%, P = .05). CONCLUSIONS: CRM patients with pushing margins presented superior disease-free survival rates compared with patients with infiltrative margins. Thus, the adoption of the margin pattern can represent a tool for improved selection of patients for adjuvant treatment.
dc.description.indexMEDLINE
dc.identifier.citationAMERICAN JOURNAL OF SURGERY, v.207, n.4, p.493-498, 2014
dc.identifier.doi10.1016/j.amjsurg.2013.05.015
dc.identifier.eissn1879-1883
dc.identifier.issn0002-9610
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/7493
dc.language.isoeng
dc.publisherEXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
dc.relation.ispartofAmerican Journal of Surgery
dc.rightsrestrictedAccess
dc.rights.holderCopyright EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
dc.subjectColorectal neoplasms
dc.subjectColorectal metastasis
dc.subjectHepatectomy
dc.subjectPathology
dc.subjectsurgical
dc.subjectRecurrence
dc.subject.otherhepatic resection
dc.subject.othersurgical margin
dc.subject.otherexpanding criteria
dc.subject.otherprognostic-factors
dc.subject.otherrectal-cancer
dc.subject.otherimpact
dc.subject.otherresectability
dc.subject.otherhepatectomy
dc.subject.othersurvival
dc.subject.wosSurgery
dc.titleTumor growth pattern as predictor of colorectal liver metastasis recurrence
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.affiliation.countryItália
hcfmusp.affiliation.countryisoit
hcfmusp.author.externalLAI, Quirino:Univ Roma La Sapienza, Umberto Policlin Rome 1, Dept Gen Surg & Organ Transplantat, I-00185 Rome, Italy
hcfmusp.citation.scopus38
hcfmusp.contributor.author-fmusphcRAFAEL SOARES NUNES PINHEIRO
hcfmusp.contributor.author-fmusphcPAULO HERMAN
hcfmusp.contributor.author-fmusphcRENATO MICELLI LUPINACCI
hcfmusp.contributor.author-fmusphcEVANDRO SOBROZA DE MELLO
hcfmusp.contributor.author-fmusphcFABRICIO FERREIRA COELHO
hcfmusp.contributor.author-fmusphcMARCOS VINICIUS PERINI
hcfmusp.contributor.author-fmusphcVINCENZO PUGLIESE
hcfmusp.contributor.author-fmusphcWELLINGTON ANDRAUS
hcfmusp.contributor.author-fmusphcIVAN CECCONELLO
hcfmusp.contributor.author-fmusphcLUIZ AUGUSTO CARNEIRO D ALBUQUERQUE
hcfmusp.description.beginpage493
hcfmusp.description.endpage498
hcfmusp.description.issue4
hcfmusp.description.volume207
hcfmusp.origemWOS
hcfmusp.origem.pubmed24112674
hcfmusp.origem.scopus2-s2.0-84897008540
hcfmusp.origem.wosWOS:000333416100007
hcfmusp.publisher.cityBRIDGEWATER
hcfmusp.publisher.countryUSA
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