Intense pulsed light in photoaging: a clinical, histopathological and immunohistochemical evaluation

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorPATRIOTA, Regia Celli Ribeiro
dc.contributor.authorRODRIGUES, Consuelo Junqueira
dc.contributor.authorCUCE, Luiz Carlos
dc.date.accessioned2017-11-27T16:33:06Z
dc.date.available2017-11-27T16:33:06Z
dc.date.issued2011
dc.description.abstractBACKGROUND: Intense pulsed light has been used in the treatment of photoaging without a full understanding of its mechanism of action. OBJECTIVE: To study the effect of intense pulsed light on photoaging and on the skin immune response by means of a clinical and histopathological study, evaluating Langerhans cells (CD1), expression of intercellular adhesion molecule, of CD4 and CD8 lymphocytes and quantification of collagen and elastic fibers. METHODS: In 2006 a total of 26 patients, aged 40 to 65 years, with phototypes II to III (Fitzpatrick scale), were treated for photoaging using intense pulsed light in five sessions with a monthly interval. All the patients were subjected to histological and immunohistochemical evaluation 6 months after treatment. RESULTS: At the end of the treatment clinical improvement was observed in 76.92% of cases. This improvement was associated to a significant increase of collagen (51.33%) and elastic (44.13%) fibers. Intense pulsed light treatment led to a reduction of CD4 lymphocytes and did not alter the amount of CD8 lymphocytes. It also led to a significant increase of small, nonectatic blood vessels, positive intercellular adhesion molecule. CONCLUSION: Facial treatment with intense pulsed light promoted major clinical improvement that was confirmed by histological examination of the skin. This technique is a good treatment option for skin photoaging because it is non-ablative, safe and effective.
dc.description.abstractFUNDAMENTOS: A luz intensa pulsada tem sido muito utilizada no tratamento do fotoenvelhecimento sem completo conhecimento de seu mecanismo de ação. OBJETIVO: Estudar a ação da luz intensa pulsada no fotoenvelhecimento e na resposta imunológica cutânea por meio de estudo clínico, histopatológico, avaliando células de Langerhans (CD1), expressão da molécula de adesão intercelular, de linfócitos CD4 e CD8 e quantificação de colágeno e fibras elásticas. MÉTODOS: Um total de 26 pacientes, com idades entre 40 e 65 anos, com fototipos II a III de Fitzpatrick, foram tratadas do fotoenvelhecimento usando LIP, em 5 sessões, com intervalo mensal, durante o ano de 2006. Todas as pacientes foram submetidas à avaliação histológica e imuno-histoquímica 6 meses após o tratamento. RESULTADOS: Ao término do tratamento, houve melhora clínica em 76,92% dos casos, estando relacionada ao aumento significante de fibras colágenas (51,33%) e elásticas (44,13%). O tratamento com luz intensa pulsada promoveu redução de linfócitos CD4 e não alterou a intensidade de linfócitos CD8. Além disso, promoveu aumento significante de pequenos vasos sanguíneos, não ectásicos, molécula de adesão intercelular positivos. CONCLUSÃO: O tratamento facial com luz intensa pulsada promoveu intensa melhora clínica que foi comprovada pelo estudo histopatológico da pele, constituindo boa opção de tratamento para o fotoenvelhecimento cutâneo, por ser técnica não- ablativa, segura e eficaz
dc.description.indexMEDLINE
dc.identifier.citationANAIS BRASILEIROS DE DERMATOLOGIA, v.86, n.6, p.1129-1133, 2011
dc.identifier.issn0365-0596
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/23262
dc.language.isopor
dc.language.isoeng
dc.publisherSOC BRASILEIRA DERMATOLOGIA
dc.relation.ispartofAnais Brasileiros de Dermatologia
dc.rightsopenAccess
dc.rights.holderCopyright SOC BRASILEIRA DERMATOLOGIA
dc.subjectCollagen
dc.subjectElastic tissue
dc.subjectLasers
dc.subjectSkin aging
dc.subjectRejuvenation
dc.subjectColágeno
dc.subjectEnvelhecimento da pele
dc.subjectLasers
dc.subjectRejuvenescimento
dc.subjectTecido elástico
dc.subject.othernd-yag laser
dc.subject.otherhistologic evaluation
dc.subject.othernonablative treatment
dc.subject.otherskin rejuvenation
dc.subject.otherrhytids
dc.subject.wosDermatology
dc.titleIntense pulsed light in photoaging: a clinical, histopathological and immunohistochemical evaluation
dc.title.alternativeLuz intensa pulsada no fotoenvelhecimento: avaliação clínica, histopatológica e imuno-histoquímica
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.citation.scopus19
hcfmusp.contributor.author-fmusphcREGIA CELLI PATRIOTA DE SICA
hcfmusp.contributor.author-fmusphcCONSUELO JUNQUEIRA RODRIGUES
hcfmusp.contributor.author-fmusphcLUIZ CARLOS CUCE
hcfmusp.description.beginpage1129
hcfmusp.description.endpage1133
hcfmusp.description.issue6
hcfmusp.description.volume86
hcfmusp.origemWOS
hcfmusp.origem.pubmed22281900
hcfmusp.origem.scopus2-s2.0-84856615866
hcfmusp.origem.wosWOS:000299512700010
hcfmusp.publisher.cityRIO DE JANEIRO RJ
hcfmusp.publisher.countryBRAZIL
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hcfmusp.scopus.lastupdate2024-05-17
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