Combining discovery and targeted proteomics reveals a prognostic signature in oral cancer

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art_CARNIELLI_Combining_discovery_and_targeted_proteomics_reveals_a_prognostic_2018.PDF (3.06 MB)
Citações na Scopus
125
Tipo de produção
article
Data de publicação
2018
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
NATURE PUBLISHING GROUP
Autores
CARNIELLI, Carolina Moretto
MACEDO, Carolina Carneiro Soares
ROSSI, Tatiane De
GRANATO, Daniela Campos
RIVERA, Cesar
DOMINGUES, Romenia Ramos
PAULETTI, Bianca Alves
YOKOO, Sami
HEBERLE, Henry
BUSSO-LOPES, Ariane Fidelis
Citação
NATURE COMMUNICATIONS, v.9, article ID 3598, 17p, 2018
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Different regions of oral squamous cell carcinoma (OSCC) have particular histopathological and molecular characteristics limiting the standard tumor-node-metastasis prognosis classification. Therefore, defining biological signatures that allow assessing the prognostic outcomes for OSCC patients would be of great clinical significance. Using histopathology-guided discovery proteomics, we analyze neoplastic islands and stroma from the invasive tumor front (ITF) and inner tumor to identify differentially expressed proteins. Potential signature proteins are prioritized and further investigated by immunohistochemistry (IHC) and targeted proteomics. IHC indicates low expression of cystatin-B in neoplastic islands from the ITF as an independent marker for local recurrence. Targeted proteomics analysis of the prioritized proteins in saliva, combined with machine-learning methods, highlights a peptide-based signature as the most powerful predictor to distinguish patients with and without lymph node metastasis. In summary, we identify a robust signature, which may enhance prognostic decisions in OSCC and better guide treatment to reduce tumor recurrence or lymph node metastasis.
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URI
https://observatorio.fm.usp.br/handle/OPI/29620
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Coleções
Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - LIM/24
Artigos e Materiais de Revistas Científicas - ODS/03