Emerging targets for combination therapy in melanomas

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Arquivos
art_SAITO_Emerging_targets_for_combination_therapy_in_melanomas_2015.PDF (1.48 MB)
Citações na Scopus
21
Tipo de produção
article
Data de publicação
2015
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
ELSEVIER SCIENCE BV
Autores
JACOMASSI, Mayara D'Auria
Citação
FEBS LETTERS, v.589, n.22, Special Issue, p.3438-3448, 2015
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Cutaneous melanomas are often difficult to treat when diagnosed in advanced stages. Melanoma cells adapt to survive in extreme environmental conditions and are among the tumors with larger genomic instability. Here we discuss some intrinsic and extrinsic mechanisms of resistance of melanoma cells to both conventional and target therapies, such as autophagy, adaptation to endoplasmic reticulum stress, metabolic reprogramming, mechanisms of tumor repopulation and the role of extracellular vesicles in this later phenomenon. These biological processes are potentially targetable and thus provide a platform for research and discovery of new drugs for combination therapy to manage melanoma patient treatment.
Palavras-chave
Melanoma, Autophagy, Unfolded protein response, Metabolic reprogramming, Tumor repopulation, PAF
URI
https://observatorio.fm.usp.br/handle/OPI/12681
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MDR
Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - LIM/24
Artigos e Materiais de Revistas Científicas - ODS/03