Phytosterols Supplementation Reduces Endothelin-1 Plasma Concentration in Moderately Hypercholesterolemic Individuals Independently of Their Cholesterol-Lowering Properties

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorILHA, Angela Oliveira Godoy
dc.contributor.authorNUNES, Valeria Sutti
dc.contributor.authorAFONSO, Milessa Silva
dc.contributor.authorNAKANDAKARE, Edna Regina
dc.contributor.authorFERREIRA, Guilherme da Silva
dc.contributor.authorBOMBO, Renata de Paula Assis
dc.contributor.authorGIORGI, Ricardo Rodrigues
dc.contributor.authorMACHADO, Roberta Marcondes
dc.contributor.authorQUINTAO, Eder Carlos Rocha
dc.contributor.authorLOTTENBERG, Ana Maria
dc.date.accessioned2020-08-20T13:19:44Z
dc.date.available2020-08-20T13:19:44Z
dc.date.issued2020
dc.description.abstractExperimental and clinical studies have demonstrated the effect of phytosterols (PS) on reducing plasma levels of cholesterol and LDL-c, but the effects of plant sterols beyond cholesterol-lowering are still questionable. Since inflammation and endothelial dysfunction are involved in the pathogenesis of atherosclerosis, this study aims to evaluate the effect of PS on biomarkers involved in atherosclerosis progression and whether these effects are independent of alterations in plasma LDL-c levels. Thirty-eight moderately hypercholesterolemic volunteers (58 +/- 12 years; LDL-c >= 130 mg/dL) were randomly assigned to consume 400 mL/day of soy milk or soy milk + PS (1.6 g/day) for 4 weeks in a double-blind, placebo-controlled, cross-over study. Blood samples were collected and lipid profiles and biomarkers for inflammation and endothelial dysfunction determined. The results showed that PS treatment reduced endothelin-1 plasma concentration by 11% (p = 0.02) independently of variations in plasma levels of LDL-c. No alterations were observed regarding fibrinogen, IL-6, hs-CRP, SAA, TNF alpha, or VCAM-1 between placebo and PS-treated groups. Furthermore, PS reduced total plasma cholesterol concentration (-5,5%, p < 0.001), LDL-c (-6.4%, p < 0.05), triglycerides (-8.3%, p < 0.05), and apo B (-5.3%, p < 0.05), without changing HDL-c concentration (p > 0.05). Therefore, PS supplementation effectively lowers endothelin-1 independently of the reductions in plasma levels of LDL-c, contributing to the comprehension of the effect of plant sterols on endothelial function and prevention of cardiovascular diseases.eng
dc.description.indexMEDLINEeng
dc.identifier.citationNUTRIENTS, v.12, n.5, article ID 1507, 10p, 2020
dc.identifier.doi10.3390/nu12051507
dc.identifier.eissn2072-6643
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/36690
dc.language.isoeng
dc.publisherMDPIeng
dc.relation.ispartofNutrients
dc.rightsopenAccesseng
dc.rights.holderCopyright MDPIeng
dc.subjectphytosterolseng
dc.subjectendothelin-1eng
dc.subjectcholesteroleng
dc.subjectinflammationeng
dc.subjectdieteng
dc.subject.otherplant sterol esterseng
dc.subject.otheratherosclerosiseng
dc.subject.otheratorvastatineng
dc.subject.otherinflammationeng
dc.subject.otherconsumptioneng
dc.subject.otherabsorptioneng
dc.subject.otherexpressioneng
dc.subject.othermarkerseng
dc.subject.otherdysfunctioneng
dc.subject.otherinhibitioneng
dc.subject.wosNutrition & Dieteticseng
dc.titlePhytosterols Supplementation Reduces Endothelin-1 Plasma Concentration in Moderately Hypercholesterolemic Individuals Independently of Their Cholesterol-Lowering Propertieseng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalILHA, Angela Oliveira Godoy:Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med, Lab Lipides LIM10, BR-01246903 Sao Paulo, Brazil
hcfmusp.author.externalAFONSO, Milessa Silva:Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med, Lab Lipides LIM10, BR-01246903 Sao Paulo, Brazil
hcfmusp.author.externalBOMBO, Renata de Paula Assis:Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med, Lab Lipides LIM10, BR-01246903 Sao Paulo, Brazil
hcfmusp.author.externalMACHADO, Roberta Marcondes:Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med, Lab Lipides LIM10, BR-01246903 Sao Paulo, Brazil
hcfmusp.citation.scopus12
hcfmusp.contributor.author-fmusphcVALERIA SUTTI NUNES
hcfmusp.contributor.author-fmusphcEDNA REGINA NAKANDAKARE
hcfmusp.contributor.author-fmusphcGUILHERME DA SILVA FERREIRA
hcfmusp.contributor.author-fmusphcRICARDO RODRIGUES GIORGI
hcfmusp.contributor.author-fmusphcEDER CARLOS ROCHA QUINTAO
hcfmusp.contributor.author-fmusphcANA MARIA PITA LOTTENBERG
hcfmusp.description.articlenumber1507
hcfmusp.description.issue5
hcfmusp.description.volume12
hcfmusp.origemWOS
hcfmusp.origem.pubmed32455866
hcfmusp.origem.scopus2-s2.0-85085184278
hcfmusp.origem.wosWOS:000542272700156
hcfmusp.publisher.cityBASELeng
hcfmusp.publisher.countrySWITZERLANDeng
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