Association of parathormone and alkaline phosphatase with bone turnover and mineralization in children with CKD on dialysis: effect of age, gender, and race

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSOEIRO, Emilia M. D.
dc.contributor.authorCASTRO, Lucimary
dc.contributor.authorMENEZES, Rejane
dc.contributor.authorELIAS, Rosilene M.
dc.contributor.authorREIS, Luciene M. dos
dc.contributor.authorJORGETTI, Vanda
dc.contributor.authorMOYSES, Rosa M. A.
dc.date.accessioned2020-08-20T13:27:45Z
dc.date.available2020-08-20T13:27:45Z
dc.date.issued2020
dc.description.abstractBackground Studies investigating bone histology in children with chronic kidney disease (CKD) are scarce. Methods Forty-two patients, mean age 11.3 +/- 4.3 years with stage 5 CKD on dialysis, underwent double tetracycline labeling bone biopsy and the relationship between clinical features, biochemical markers, and bone densitometry (DXA) was investigated. Results Low bone turnover was present in 59% of patients, abnormal mineralization in 29%, and low bone volume in 7%. Higher bone formation rate was found in non-Caucasian patients, whereas abnormal mineralization occurred in older and shorter children. We found no impact of gender and etiology of renal disease in our population. Parathormone (PTH) and alkaline phosphatase (AP) showed positive associations with bone turnover. ROC curve analysis showed a fair performance of biomarkers to predict TMV status. PTH < 2 times ULN independently associated with low bone turnover (RR 5.62, 95% CI 1.01-31.24; p = 0.049), in a model adjusted for race, calcitriol dosage, and calcium. It was also associated with abnormal mineralization (RR 1.35, 95% CI 1.04-1.75; p = 0.025), in a model adjusted for BMD scores, AP, age, and calcitriol. PTH and AP significantly predicted turnover and mineralization defect, although with low specificity and sensitivity, reaching a maximum value of 64% and 67%, respectively. Conclusions While PTH and AP were associated with turnover and mineralization, we recognize the limitation of their performance to clearly distinguish high from low/normal bone turnover and normal from abnormal mineralization. Our results reinforce the need to expand knowledge about renal osteodystrophy in pediatric population through prospective bone biopsy studies.eng
dc.description.indexMEDLINEeng
dc.description.sponsorshipCNPq, Conselho Nacional de Desenvolvimento Cientifico e TecnologicoNational Council for Scientific and Technological Development (CNPq) [305106/2018-0, 303684/2013-5, 304249/2013-0]
dc.identifier.citationPEDIATRIC NEPHROLOGY, v.35, n.7, p.1297-1305, 2020
dc.identifier.doi10.1007/s00467-020-04499-2
dc.identifier.eissn1432-198X
dc.identifier.issn0931-041X
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/37181
dc.language.isoeng
dc.publisherSPRINGEReng
dc.relation.ispartofPediatric Nephrology
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright SPRINGEReng
dc.subjectChronic kidney diseaseeng
dc.subjectBone diseaseseng
dc.subjectMetaboliceng
dc.subjectBone biopsyeng
dc.subjectHistomorphometryeng
dc.subjectRenal osteodystrophyeng
dc.subjectChildreneng
dc.subject.otherrenal osteodystrophyeng
dc.subject.otherkidney-diseaseeng
dc.subject.otherpediatric-patientseng
dc.subject.otheradynamic boneeng
dc.subject.otherhistomorphometryeng
dc.subject.otherclassificationeng
dc.subject.otherhemodialysiseng
dc.subject.othermetabolismeng
dc.subject.othercalcitrioleng
dc.subject.otherhistologyeng
dc.subject.wosPediatricseng
dc.subject.wosUrology & Nephrologyeng
dc.titleAssociation of parathormone and alkaline phosphatase with bone turnover and mineralization in children with CKD on dialysis: effect of age, gender, and raceeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalCASTRO, Lucimary:Hosp Pequeno Principe, Curitiba, Parana, Brazil
hcfmusp.author.externalMENEZES, Rejane:Hosp Pequeno Principe, Curitiba, Parana, Brazil
hcfmusp.citation.scopus14
hcfmusp.contributor.author-fmusphcEMILIA MARIA DANTAS SOEIRO
hcfmusp.contributor.author-fmusphcROSILENE MOTTA ELIAS
hcfmusp.contributor.author-fmusphcLUCIENE MACHADO DOS REIS
hcfmusp.contributor.author-fmusphcVANDA JORGETTI
hcfmusp.contributor.author-fmusphcRAQUEL AJUB MOYSES
hcfmusp.description.beginpage1297
hcfmusp.description.endpage1305
hcfmusp.description.issue7
hcfmusp.description.volume35
hcfmusp.origemWOS
hcfmusp.origem.pubmed32157445
hcfmusp.origem.scopus2-s2.0-85081253994
hcfmusp.origem.wosWOS:000519503000001
hcfmusp.publisher.cityNEW YORKeng
hcfmusp.publisher.countryUNITED STATESeng
hcfmusp.relation.referenceAndrade MC, 2007, PEDIATR NEPHROL, V22, P1767, DOI 10.1007/s00467-007-0546-7eng
hcfmusp.relation.reference[Anonymous], 2017, KIDNEY INT S, V7, P1, DOI 10.1016/j.kisu.2017.04.001eng
hcfmusp.relation.referenceBakkaloglu SA, 2010, CLIN J AM SOC NEPHRO, V5, P1860, DOI 10.2215/CJN.01330210eng
hcfmusp.relation.referenceBarreto DV, 2008, NEPHRON CLIN PRACT, V110, pC273, DOI 10.1159/000170783eng
hcfmusp.relation.referenceBarreto FC, 2008, KIDNEY INT, V73, P771, DOI 10.1038/sj.ki.5002769eng
hcfmusp.relation.referencede Oliveira RA, 2015, KIDNEY INT, V87, P1039, DOI 10.1038/ki.2014.372eng
hcfmusp.relation.referenceDempster DW, 2013, J BONE MINER RES, V28, P1, DOI 10.1002/jbmr.1805eng
hcfmusp.relation.referenceDenburg MR, 2016, J AM SOC NEPHROL, V27, P543, DOI 10.1681/ASN.2015020152eng
hcfmusp.relation.referenceDos Reis LM, 2007, J BONE MINER METAB, V25, P400, DOI 10.1007/s00774-007-0778-4eng
hcfmusp.relation.referenceDrueke TB, 2016, KIDNEY INT, V89, P289, DOI 10.1016/j.kint.2015.12.004eng
hcfmusp.relation.referenceDrueke TB, 2012, KIDNEY INT, V82, P952, DOI 10.1038/ki.2012.270eng
hcfmusp.relation.referenceGlorieux FH, 2000, BONE, V26, P103, DOI 10.1016/S8756-3282(99)00257-4eng
hcfmusp.relation.referenceGOODMAN WG, 1994, KIDNEY INT, V46, P1160, DOI 10.1038/ki.1994.380eng
hcfmusp.relation.referenceGordon CM, 2014, J CLIN DENSITOM, V17, P219, DOI 10.1016/j.jocd.2014.01.007eng
hcfmusp.relation.referenceGraciolli FG, 2017, KIDNEY INT, V91, P1436, DOI 10.1016/j.kint.2016.12.029eng
hcfmusp.relation.referenceHODSON EM, 1982, KIDNEY INT, V21, P833, DOI 10.1038/ki.1982.107eng
hcfmusp.relation.referenceJorgetti V, 2014, KIDNEY INT, V85, P1283, DOI 10.1038/ki.2013.443eng
hcfmusp.relation.referenceLalayiannis AD, 2020, PEDIATR NEPHROL, V35, P937, DOI 10.1007/s00467-019-04271-1eng
hcfmusp.relation.referenceLangman CB, 2005, AM J KIDNEY DIS, V46, pS6, DOI 10.1053/j.ajkd.2005.07.024eng
hcfmusp.relation.referenceLaster M, 2019, BONE, V127, P114, DOI 10.1016/j.bone.2019.06.004eng
hcfmusp.relation.referenceLobao R, 2004, CLIN NEPHROL, V62, P432eng
hcfmusp.relation.referenceMATHIAS R, 1993, J AM SOC NEPHROL, V3, P1938eng
hcfmusp.relation.referenceMoe S, 2006, KIDNEY INT, V69, P1945, DOI 10.1038/sj.ki.5000414eng
hcfmusp.relation.referenceNORMAN ME, 1980, J PEDIATR-US, V97, P226, DOI 10.1016/S0022-3476(80)80479-3eng
hcfmusp.relation.referenceSALUSKY IB, 1988, KIDNEY INT, V33, P975, DOI 10.1038/ki.1988.96eng
hcfmusp.relation.referenceSALUSKY IB, 1994, KIDNEY INT, V45, P253, DOI 10.1038/ki.1994.31eng
hcfmusp.relation.referenceSanchez CP, 2000, PEDIATR NEPHROL, V14, P646, DOI 10.1007/s004670000354eng
hcfmusp.relation.referenceSirimongkolchaiyakul O, 2017, J AM SOC NEPHROL, V28, P1, DOI [10.1681/ASN.2016070785, DOI 10.1681/ASN.2016070785]eng
hcfmusp.relation.referenceSprague SM, 2016, AM J KIDNEY DIS, V67, P559, DOI 10.1053/j.ajkd.2015.06.023eng
hcfmusp.relation.referenceWaller S, 2008, PEDIATR NEPHROL, V23, P1523, DOI 10.1007/s00467-008-0838-6eng
hcfmusp.relation.referenceWesseling-Perry K, 2015, CURR OSTEOPOROS REP, V13, P98, DOI 10.1007/s11914-015-0253-4eng
hcfmusp.relation.referenceWesseling-Perry K, 2012, CLIN J AM SOC NEPHRO, V7, P146, DOI 10.2215/CJN.05940611eng
hcfmusp.relation.referenceWesseling-Perry K, 2011, KIDNEY INT, V79, P112, DOI 10.1038/ki.2010.352eng
hcfmusp.relation.referenceYalcinkaya F, 2000, PEDIATR INT, V42, P53, DOI 10.1046/j.1442-200x.2000.01171.xeng
hcfmusp.relation.referenceYoung EW, 2005, KIDNEY INT, V67, P1179, DOI 10.1111/j.1523-1755.2005.00185.xeng
hcfmusp.relation.referenceZiolkowska H, 2000, ACTA PAEDIATR, V89, P666, DOI 10.1080/080352500750043963eng
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