Preventive and therapeutic moderate aerobic exercise programs convert atherosclerotic plaques into a more stable phenotype

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorCARDINOT, Themis M.
dc.contributor.authorLIMA, Thais M.
dc.contributor.authorMORETTI, Ana I. S.
dc.contributor.authorKOIKE, Marcia K.
dc.contributor.authorNUNES, Valeria S.
dc.contributor.authorCAZITA, Patricia M.
dc.contributor.authorKRIEGER, Marta H.
dc.contributor.authorBRUM, Patricia C.
dc.contributor.authorSOUZA, Heraldo P.
dc.date.accessioned2016-07-18T11:40:45Z
dc.date.available2016-07-18T11:40:45Z
dc.date.issued2016
dc.description.abstractThe mechanisms by which exercise affects atherosclerotic plaque stability remain incompletely understood. We evaluated the effects of two training protocols on both atherosclerotic plaque structure and the signaling pathways involved in plaque rupture. Methods: Male low-density lipoprotein (LDL) receptor knockout mice were fed a high-fat, high-cholesterol diet (HFD). One group was subjected to moderate exercise using a treadmill for 14 weeks (preventive protocol). The other group started an exercise regimen after 16 weeks of the HFD (therapeutic group). Atherosclerotic plaques within the aorta were evaluated for lipid and collagen contents, as well as for inflammatory markers. Plasma cholesterol and cytokine levels were also determined. Results: The mice receiving a HFD developed hypercholesterolemia and atherosclerotic plaques within the aorta. The aortas from the animals in the preventive protocol exhibited smaller lipid cores and higher collagen content. These animals also exhibited lower CD40 expression within the plaques. The aortas of the mice in the therapeutic group exhibited higher collagen content, but no differences in either lipid core size or plaque size were noted. No differences in blood pressure, plasma cholesterol, cytokine levels, plaque size or metalloproteinase 9 expression were observed in the trained animals compared with the sedentary animals. Conclusion: Moderate aerobic exercise modified atherosclerotic plaque characteristics and converted the plaques into a more stable phenotype, increasing the collagen content in response to both exercise programs. Furthermore, moderate aerobic exercise reduced the animals' fat content and decreased the activity of the CD40-CD40L signaling pathway in the preventive group.
dc.description.indexMEDLINE
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo [2009/01990-9]
dc.identifier.citationLIFE SCIENCES, v.153, p.163-170, 2016
dc.identifier.doi10.1016/j.lfs.2016.04.007
dc.identifier.eissn1879-0631
dc.identifier.issn0024-3205
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/14116
dc.language.isoeng
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.relation.ispartofLife Sciences
dc.rightsrestrictedAccess
dc.rights.holderCopyright PERGAMON-ELSEVIER SCIENCE LTD
dc.subjectAtherosclerosis
dc.subjectAerobic exercise
dc.subjectPlaque stability
dc.subjectHigh fat diet
dc.subject.otherrisk-assessment strategies
dc.subject.otherreceptor knockout mice
dc.subject.otherc-reactive protein
dc.subject.otherhigh-fat diet
dc.subject.otherphysical-activity
dc.subject.otherendurance exercise
dc.subject.othervulnerable patient
dc.subject.otherdeficient mice
dc.subject.otherheart-disease
dc.subject.othercoronary
dc.subject.wosMedicine, Research & Experimental
dc.subject.wosPharmacology & Pharmacy
dc.titlePreventive and therapeutic moderate aerobic exercise programs convert atherosclerotic plaques into a more stable phenotype
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalCARDINOT, Themis M.:Univ Sao Paulo, Fac Med, Emergency Med Dept LIM 51, Sao Paulo, Brazil
hcfmusp.author.externalMORETTI, Ana I. S.:Univ Sao Paulo, Fac Med, Emergency Med Dept LIM 51, Sao Paulo, Brazil
hcfmusp.author.externalKRIEGER, Marta H.:Univ Estadual Campinas, Inst Biol, Dept Physiol & Biophys, Campinas, SP, Brazil
hcfmusp.author.externalBRUM, Patricia C.:Univ Sao Paulo, Sch Phys Educ & Sports, Sao Paulo, Brazil
hcfmusp.citation.scopus6
hcfmusp.contributor.author-fmusphcTHAIS MARTINS DE LIMA
hcfmusp.contributor.author-fmusphcMARCIA KIYOMI KOIKE
hcfmusp.contributor.author-fmusphcVALERIA SUTTI NUNES
hcfmusp.contributor.author-fmusphcPATRICIA MIRALDA CAZITA
hcfmusp.contributor.author-fmusphcHERALDO POSSOLO DE SOUZA
hcfmusp.description.beginpage163
hcfmusp.description.endpage170
hcfmusp.description.volume153
hcfmusp.origemWOS
hcfmusp.origem.pubmed27074350
hcfmusp.origem.scopus2-s2.0-84966397579
hcfmusp.origem.wosWOS:000376484500019
hcfmusp.publisher.cityOXFORD
hcfmusp.publisher.countryENGLAND
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