Potentially inappropriate medications and cognitive performance: cross-sectional results from the ELSA-Brasil study

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSANTOS, Adriana Nancy Medeiros dos
dc.contributor.authorFARIAS-IAO, Daniela Souza
dc.contributor.authorBENSENOR, Isabela M.
dc.contributor.authorGOULART, Alessandra C.
dc.contributor.authorBRUNONI, Andre R.
dc.contributor.authorVIANA, Maria Carmen
dc.contributor.authorLOTUFO, Paulo A.
dc.contributor.authorSUEMOTO, Claudia Kimie
dc.date.accessioned2023-08-16T17:45:29Z
dc.date.available2023-08-16T17:45:29Z
dc.date.issued2023
dc.description.abstractObjectivesPotentially inappropriate medications (PIM), especially those with potential effects on the central nervous system, can increase the risk of cognitive impairment. We investigated the association of the use of PIM and PIM that may impair cognition (PIM-Cog) with cognitive performance among older adults.MethodsIn this cross-sectional study with 2,626 participants, PIM and PIM-Cog were defined by the 2019 American Geriatrics Society Beers criteria. We calculated global cognition and memory, verbal fluency, and Trail Making Test B version (TMT-B) z-scores. Linear regression models adjusted for sociodemographic and clinical variables were used to investigate the association between PIM and cognition.Results27% and 7% of the sample (mean age = 65.1 +/- 4.1 years old, 54% women, and 61% White) used at least one PIM and PIM-cog, respectively. PIM was associated with poor performance in the TMT-B (beta = -0.17, 95% Cl = -0.29; -0.05, p = 0.007). PIM-Cog was also associated with poor TMT-B performance (beta = -0.08, 95% Cl = -0.15; -0.01, p = 0.025).ConclusionThe use of PIM and PIM-Cog was associated with poor executive function among older adults. The review of PIM use and the deprescription of these drugs may be an effective way to improve cognitive function.eng
dc.description.indexMEDLINE
dc.description.indexPubMed
dc.description.indexWoS
dc.description.indexScopus
dc.description.sponsorshipBrazilian Ministry of Health
dc.description.sponsorshipCNPq [01060010.00RS, 01060212.00BA, 01060300.00ES, 01060278.00MG, 01060115.00SP, 01060071.00RJ]
dc.description.sponsorshipDSF-I received a scholarship from Sao Paulo Research Foundation (FAPESP) [2017/24066-1]
dc.identifier.citationEUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, v.79, n.7, p.927-934, 2023
dc.identifier.doi10.1007/s00228-023-03504-5
dc.identifier.eissn1432-1041
dc.identifier.issn0031-6970
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/54561
dc.language.isoeng
dc.publisherSPRINGER HEIDELBERGeng
dc.relation.ispartofEuropean Journal of Clinical Pharmacology
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright SPRINGER HEIDELBERGeng
dc.subjectPotentiallyeng
dc.subjectInappropriateeng
dc.subjectMedicationeng
dc.subjectCognitioneng
dc.subjectDementiaeng
dc.subjectDrug utilizationeng
dc.subject.othercriteriaeng
dc.subject.wosPharmacology & Pharmacyeng
dc.titlePotentially inappropriate medications and cognitive performance: cross-sectional results from the ELSA-Brasil studyeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalVIANA, Maria Carmen:Univ Fed Espirito Santo, Ctr Psychiat Epidemiol CEPEP, Dept Social Med, Postgrad Program Publ Hlth, Vitoria, Brazil
hcfmusp.citation.scopus0
hcfmusp.contributor.author-fmusphcADRIANA NANCY MEDEIROS DOS SANTOS
hcfmusp.contributor.author-fmusphcDANIELA SOUZA FARIAS ITAO
hcfmusp.contributor.author-fmusphcISABELA JUDITH MARTINS BENSEñOR
hcfmusp.contributor.author-fmusphcALESSANDRA CARVALHO GOULART
hcfmusp.contributor.author-fmusphcANDRE RUSSOWSKY BRUNONI
hcfmusp.contributor.author-fmusphcPAULO ANDRADE LOTUFO
hcfmusp.contributor.author-fmusphcCLAUDIA KIMIE SUEMOTO
hcfmusp.description.beginpage927
hcfmusp.description.endpage934
hcfmusp.description.issue7
hcfmusp.description.volume79
hcfmusp.origemWOS
hcfmusp.origem.pubmed37162515
hcfmusp.origem.scopus2-s2.0-85159046003
hcfmusp.origem.wosWOS:000985239400001
hcfmusp.publisher.cityHEIDELBERGeng
hcfmusp.publisher.countryGERMANYeng
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hcfmusp.scopus.lastupdate2024-05-17
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