The Mechanoreceptor's Role in Plantar Skin Changes in Individuals with Diabetes Mellitus

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorZIPPENFENNIG, Claudio
dc.contributor.authorDRECHSEL, Tina J.
dc.contributor.authorMONTEIRO, Renan L.
dc.contributor.authorSACCO, Isabel C. N.
dc.contributor.authorMILANI, Thomas L.
dc.date.accessioned2021-08-13T15:13:19Z
dc.date.available2021-08-13T15:13:19Z
dc.date.issued2021
dc.description.abstractMechanical skin properties (MSPs) and vibration perception thresholds (VPTs) show no relationship in healthy subjects. Similar results were expected when comparing MSP and VPT in individuals with diabetes mellitus (DM) and with diabetic (peripheral-)neuropathy (DPN). A healthy control group (33 CG), 20 DM and 13 DPN participated in this cross-sectional study. DM and DPN were classified by using a fuzzy decision support system. VPTs (in mu m) were measured with a modified vibration exciter at two different frequencies (30 and 200 Hz) and locations (heel, first metatarsal head). Skin hardness (durometer readings) and thickness (ultrasound) were measured at the same locations. DPN showed the highest VPTs compared to DM and CG at both frequencies and locations. Skin was harder in DPN compared to CG (heel). No differences were observed in skin thickness. VPTs at 30 and 200 Hz correlated negatively with skin hardness for DPN and with skin thickness for DM, respectively. This means, the harder or thicker the skin, the better the perception of 30 or 200 Hz vibrations. Changes in MSP may compensate the loss of sensitivity up to a certain progression of the disease. However, the influence seems rather small when considering other parameters, such as age.eng
dc.description.indexPubMedeng
dc.description.sponsorshipSachsische Aufbaubank (SAB) from the European Social Fund (ESF)
dc.description.sponsorshipFree State of Saxony
dc.description.sponsorshipState of Sao Paulo Research Foundation (FAPESP)Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2017/17848-3]
dc.description.sponsorshipNational Council for Scientific and Technological Development (CNPq), BrazilConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ) [304124/2018-4]
dc.description.sponsorshipChemnitz University of Technology
dc.identifier.citationJOURNAL OF CLINICAL MEDICINE, v.10, n.12, article ID 2537, 11p, 2021
dc.identifier.doi10.3390/jcm10122537
dc.identifier.eissn2077-0383
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/41423
dc.language.isoeng
dc.publisherMDPIeng
dc.relation.ispartofJournal of Clinical Medicine
dc.rightsopenAccesseng
dc.rights.holderCopyright MDPIeng
dc.subjectskin hardnesseng
dc.subjectskin thicknesseng
dc.subjectvibration perception thresholdeng
dc.subjectmechanoreceptorseng
dc.subjectsensory perceptioneng
dc.subjectdiabetic neuropathyeng
dc.subject.othermechanical-propertieseng
dc.subject.otherneuropathyeng
dc.subject.otherassociationeng
dc.subject.otherthicknesseng
dc.subject.otherhardnesseng
dc.subject.othergendereng
dc.subject.otheronseteng
dc.subject.othergaiteng
dc.subject.othersoleeng
dc.subject.otherageeng
dc.subject.wosMedicine, General & Internaleng
dc.titleThe Mechanoreceptor's Role in Plantar Skin Changes in Individuals with Diabetes Mellituseng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryAlemanha
hcfmusp.affiliation.countryisode
hcfmusp.author.externalZIPPENFENNIG, Claudio:Tech Univ Chemnitz, Fac Behav & Social Sci, Inst Human Movement Sci & Hlth, Dept Human Locomot, D-09107 Chemnitz, Germany
hcfmusp.author.externalDRECHSEL, Tina J.:Tech Univ Chemnitz, Fac Behav & Social Sci, Inst Human Movement Sci & Hlth, Dept Human Locomot, D-09107 Chemnitz, Germany
hcfmusp.author.externalMILANI, Thomas L.:Tech Univ Chemnitz, Fac Behav & Social Sci, Inst Human Movement Sci & Hlth, Dept Human Locomot, D-09107 Chemnitz, Germany
hcfmusp.citation.scopus11
hcfmusp.contributor.author-fmusphcRENAN LIMA MONTEIRO
hcfmusp.contributor.author-fmusphcISABEL DE CAMARGO NEVES SACCO
hcfmusp.description.articlenumber2537
hcfmusp.description.issue12
hcfmusp.description.volume10
hcfmusp.origemWOS
hcfmusp.origem.pubmed34201094
hcfmusp.origem.scopus2-s2.0-85114076430
hcfmusp.origem.wosWOS:000666466600001
hcfmusp.publisher.cityBASELeng
hcfmusp.publisher.countrySWITZERLANDeng
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