Glycogen Synthase Kinase-3 beta: Variation over Time and the Possible Association with Mood and Cognition in Healthy Individuals
dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | |
dc.contributor.author | MUNKHOLM, Klaus | |
dc.contributor.author | LENSKJOLD, Toke | |
dc.contributor.author | JACOBY, Anne Sophie | |
dc.contributor.author | MISKOWIAK, Kamilla Woznica | |
dc.contributor.author | VINBERG, Maj | |
dc.contributor.author | JOAQUIM, Helena Giroud Passarelli | |
dc.contributor.author | TALIB, Leda Leme | |
dc.contributor.author | GATTAZ, Wagner Farid | |
dc.contributor.author | KESSING, Lars Vedel | |
dc.date.accessioned | 2016-07-18T12:22:38Z | |
dc.date.available | 2016-07-18T12:22:38Z | |
dc.date.issued | 2016 | |
dc.description.abstract | Evidence indicates a role for glycogen synthase kinase-3 beta (GSK-3 beta) in the pathophysiology of mood disorders and in cognitive disturbances; however, the natural variation in GSK-3 beta activity over time is unknown. We aimed to investigate GSK-3 beta activity over time and its possible correlation with emotional lability, subjective mood fluctuations and cognitive function in healthy individuals. Thirty-seven healthy subjects were evaluated with neuropsychological tests and blood samples at baseline and 12-week follow-up. Total GSK-3 beta and serine-9-phosphorylated GSK-3 beta in peripheral blood mononuclear cells were quantitated using enzyme immunometric assays. The activity of GSK-3 beta (serine-9-phosphorylated GSK-3 beta/total GSK-3 beta) was lower at baseline compared with follow-up. No significant mean change over time was observed in levels of total GSK-3 beta and serine-9-phosphorylated GSK-3 beta. Exploratory analysis revealed lower activity of GSK-3 beta in spring and summer compared with the fall season. No correlation was observed between GSK-3 beta activity and emotional lability, subjective mood fluctuations or cognitive function. The results suggest that intra- and interindividual variation in GSK-3 beta activity over time could contribute to the heterogeneity of findings in clinical studies. The stability of GSK-3 beta activity and the role of potential moderators of GSK-3 beta activity warrant further investigation. Clinical studies of GSK-3 beta should consider including repeated measures of both cases and healthy individuals. (C) 2016 S. Karger AG, Basel | |
dc.description.index | MEDLINE | |
dc.description.sponsorship | Lundbeck Foundation | |
dc.identifier.citation | NEUROPSYCHOBIOLOGY, v.73, n.2, p.108-115, 2016 | |
dc.identifier.doi | 10.1159/000444489 | |
dc.identifier.eissn | 1423-0224 | |
dc.identifier.issn | 0302-282X | |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/14365 | |
dc.language.iso | eng | |
dc.publisher | KARGER | |
dc.relation.ispartof | Neuropsychobiology | |
dc.rights | restrictedAccess | |
dc.rights.holder | Copyright KARGER | |
dc.subject | Bipolar disorder | |
dc.subject | Peripheral blood | |
dc.subject | Biomarker | |
dc.subject.other | bipolar disorder patients | |
dc.subject.other | alzheimers-disease | |
dc.subject.other | elevated levels | |
dc.subject.other | prefrontal cortex | |
dc.subject.other | lithium treatment | |
dc.subject.other | arachidonic-acid | |
dc.subject.other | gene-expression | |
dc.subject.other | protein-levels | |
dc.subject.other | rating-scale | |
dc.subject.other | kinase-b | |
dc.subject.wos | Neurosciences | |
dc.subject.wos | Psychiatry | |
dc.subject.wos | Psychology | |
dc.title | Glycogen Synthase Kinase-3 beta: Variation over Time and the Possible Association with Mood and Cognition in Healthy Individuals | |
dc.type | article | |
dc.type.category | original article | |
dc.type.version | publishedVersion | |
dspace.entity.type | Publication | |
hcfmusp.affiliation.country | Dinamarca | |
hcfmusp.affiliation.countryiso | dk | |
hcfmusp.author.external | MUNKHOLM, Klaus:Univ Copenhagen, Rigshosp, Psychiat Ctr Copenhagen, Dept O, DK-2100 Copenhagen, Denmark | |
hcfmusp.author.external | LENSKJOLD, Toke:Univ Copenhagen, Rigshosp, Psychiat Ctr Copenhagen, Dept O, DK-2100 Copenhagen, Denmark | |
hcfmusp.author.external | JACOBY, Anne Sophie:Univ Copenhagen, Rigshosp, Psychiat Ctr Copenhagen, Dept O, DK-2100 Copenhagen, Denmark | |
hcfmusp.author.external | MISKOWIAK, Kamilla Woznica:Univ Copenhagen, Rigshosp, Psychiat Ctr Copenhagen, Dept O, DK-2100 Copenhagen, Denmark | |
hcfmusp.author.external | VINBERG, Maj:Univ Copenhagen, Rigshosp, Psychiat Ctr Copenhagen, Dept O, DK-2100 Copenhagen, Denmark | |
hcfmusp.author.external | JOAQUIM, Helena Giroud Passarelli:Univ Sao Paulo, Fac Med, Neurosci Lab, Dept & Inst Psychiat, Sao Paulo, Brazil | |
hcfmusp.author.external | KESSING, Lars Vedel:Univ Copenhagen, Rigshosp, Psychiat Ctr Copenhagen, Dept O, DK-2100 Copenhagen, Denmark; Univ Copenhagen, Fac Hlth & Med Sci, Copenhagen, Denmark | |
hcfmusp.citation.scopus | 5 | |
hcfmusp.contributor.author-fmusphc | LEDA LEME TALIB | |
hcfmusp.contributor.author-fmusphc | WAGNER FARID GATTAZ | |
hcfmusp.description.beginpage | 108 | |
hcfmusp.description.endpage | 115 | |
hcfmusp.description.issue | 2 | |
hcfmusp.description.volume | 73 | |
hcfmusp.origem | WOS | |
hcfmusp.origem.pubmed | 27003416 | |
hcfmusp.origem.scopus | 2-s2.0-84961393803 | |
hcfmusp.origem.wos | WOS:000375025200005 | |
hcfmusp.publisher.city | BASEL | |
hcfmusp.publisher.country | SWITZERLAND | |
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hcfmusp.scopus.lastupdate | 2024-04-12 | |
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relation.isAuthorOfPublication | 125dcc9f-a05a-42fd-ab1d-b6db35d2616b | |
relation.isAuthorOfPublication.latestForDiscovery | 65a65251-2a2e-454e-991f-07d85966f440 |
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