Combined polyglycolic acid tube and autografting versus autografting or polyglycolic acid tube alone. A comparative study of peripheral nerve regeneration in rats

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorCOSTA, Marcio Paulino
dc.contributor.authorTEIXEIRA, Nuberto Hopfgartner
dc.contributor.authorLONGO, Marco Vinicius Losso
dc.contributor.authorGEMPERLI, Rolf
dc.contributor.authorCOSTA, Heloisa Juliana Zabeu Rossi
dc.date.accessioned2015-07-01T20:15:57Z
dc.date.available2015-07-01T20:15:57Z
dc.date.issued2015
dc.description.abstractPURPOSE: To compare sciatic nerve regeneration in rats using three different techniques of repair. METHODS: Fifteen isogonics rats were divided into three groups according to the method used to repair a 5-mm long defect created in the sciatic nerve: autogenous graft (Group A), polyglycolic acid tube (PGAt) (Group B), and of the association of PGAt with the graft (Group C). Histological analysis, regenerated myelinated axon number count and functional analysis were used to compare after six weeks. RESULTS: There was no difference in fiber diameter and degree of myelinization presented by Groups A, B and C. Group B presented the lowest number of regenerated axons. The groups did not display any significant functional difference after walking track analysis (p<0.05). CONCLUSION: No differences between the three groups in terms of functional recovery, although there were histological differences among them.
dc.description.indexMEDLINE
dc.identifier.citationACTA CIRURGICA BRASILEIRA, v.30, n.1, p.46-53, 2015
dc.identifier.doi10.1590/S0102-86502015001000006
dc.identifier.eissn1678-2674
dc.identifier.issn0102-8650
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/9227
dc.language.isoeng
dc.publisherACTA CIRURGICA BRASILEIRA
dc.relation.ispartofActa Cirurgica Brasileira
dc.rightsopenAccess
dc.rights.holderCopyright ACTA CIRURGICA BRASILEIRA
dc.subjectPeripheral Nerves
dc.subjectSurgery
dc.subjectPlastic
dc.subjectNerve Regeneration
dc.subjectPolyglycolic Acid
dc.subjectTherapeutic Uses
dc.subjectRats
dc.subject.otherstem-cells
dc.subject.otherrepair
dc.subject.otherconduits
dc.subject.othergap
dc.subject.othercollagen
dc.subject.othergraft
dc.subject.otherreconstruction
dc.subject.othertubulization
dc.subject.othersuture
dc.subject.wosSurgery
dc.titleCombined polyglycolic acid tube and autografting versus autografting or polyglycolic acid tube alone. A comparative study of peripheral nerve regeneration in rats
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.citation.scopus4
hcfmusp.contributor.author-fmusphcMARCIO PAULINO COSTA
hcfmusp.contributor.author-fmusphcNUBERTO HOPFGARTNER TEIXEIRA
hcfmusp.contributor.author-fmusphcMARCO VINICIUS LOSSO LONGO
hcfmusp.contributor.author-fmusphcROLF GEMPERLI
hcfmusp.contributor.author-fmusphcHELOISA JULIANA ZABEU ROSSI COSTA
hcfmusp.description.beginpage46
hcfmusp.description.endpage53
hcfmusp.description.issue1
hcfmusp.description.volume30
hcfmusp.origemWOS
hcfmusp.origem.pubmed25627270
hcfmusp.origem.scieloSCIELO:S0102-86502015000100046
hcfmusp.origem.scopus2-s2.0-84921996974
hcfmusp.origem.wosWOS:000348793300006
hcfmusp.publisher.citySAO PAULO
hcfmusp.publisher.countryBRAZIL
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