Methotrexate for refractory adult atopic dermatitis leads to alterations in cutaneous IL-31 and IL-31RA expression

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSAMORANO, Luciana Paula
dc.contributor.authorMANFRERE, Kelly Cristina Gomes
dc.contributor.authorPEREIRA, Naiura Vieira
dc.contributor.authorTAKAOKA, Roberto
dc.contributor.authorVALENTE, Neusa Yuriko Sakai
dc.contributor.authorSOTTO, Mirian Nacagami
dc.contributor.authorSILVA, Luiz Fernando Ferraz
dc.contributor.authorSATO, Maria Notomi
dc.contributor.authorAOKI, Valeria
dc.date.accessioned2024-04-05T19:35:45Z
dc.date.available2024-04-05T19:35:45Z
dc.date.issued2024
dc.description.abstractBackground: Methotrexate (MTX) is an alternative treatment for patients with moderate/severe atopic dermatitis (AD). Objective: The authors evaluated the effect of MTX on the cutaneous expression of cytokines and chemokines that are involved in the inflammatory response in adult AD patients who received treatment with methotrexate for 24 weeks. Methods: The authors conducted a prospective single-institution cohort study with 12 adults with moderate/severe AD who received oral MTX (15 mg/wk for 24 wks) and 10 non-atopic matched controls. The comparison was made of skin biopsies of lesional and non-lesional skin, pre- and post MTX treatment. The authors analyzed mean epidermal thickness and expression of IL-31, IL-31RA, OSMR, TSLP, Ki67, IL-4 mRNA, IL-6, IL-10, TNF-alpha, IFN-gamma, TARC, and CCL-22. Results: There was a reduction in mean epidermal thickness (p = 0.021), an increase in IL-31RA expression (immunohistochemistry) in the epidermis (p = 0.016) and a decrease in IL-31 gene expression (p = 0.019) on lesional AD skin post-MTX treatment. No significant changes in the cutaneous expression of the other evaluated markers were identified. Study limitations: Small sample size and limited length of follow-up. Conclusions: Treatment with MTX in adults with moderate/severe AD reduced epidermal hyperplasia and changed the cutaneous expression of inflammatory cytokines and receptors that are mainly related to pruritus, including IL-31 and IL-31RA. (c) 2023 Published by Elsevier Espana, S.L.U. on behalf of Sociedade Brasileira de Dermatologia. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).eng
dc.description.indexMEDLINE
dc.description.indexPubMed
dc.description.indexScopus
dc.description.indexDimensions
dc.description.indexWoS
dc.description.sponsorshipFundo de Apoio a Dermatologia de Sao Paulo [23-2015]
dc.identifier.citationANAIS BRASILEIROS DE DERMATOLOGIA, v.99, n.1, p.72-79, 2024
dc.identifier.doi10.1016/j.abd.2023.01.002
dc.identifier.eissn1806-4841
dc.identifier.issn0365-0596
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/59037
dc.language.isoeng
dc.publisherELSEVIER SCIENCE INCeng
dc.relation.ispartofAnais Brasileiros de Dermatologia
dc.rightsopenAccesseng
dc.rights.holderCopyright ELSEVIER SCIENCE INCeng
dc.subjectDermatitis, atopiceng
dc.subjectInflammationeng
dc.subjectInterleukinseng
dc.subjectMethotrexateeng
dc.subjectPrurituseng
dc.subjectReceptors, interleukinseng
dc.subject.othert-cellseng
dc.subject.othercytokineseng
dc.subject.otherprurituseng
dc.subject.othertrialeng
dc.subject.wosDermatologyeng
dc.titleMethotrexate for refractory adult atopic dermatitis leads to alterations in cutaneous IL-31 and IL-31RA expressioneng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.citation.scopus0
hcfmusp.contributor.author-fmusphcLUCIANA DE PAULA SAMORANO
hcfmusp.contributor.author-fmusphcKELLY CRISTINA GOMES MANFRERE
hcfmusp.contributor.author-fmusphcNAIURA VIEIRA PEREIRA
hcfmusp.contributor.author-fmusphcROBERTO TAKAOKA
hcfmusp.contributor.author-fmusphcNEUSA YURIKO SAKAI VALENTE
hcfmusp.contributor.author-fmusphcMIRIAN NACAGAMI SOTTO
hcfmusp.contributor.author-fmusphcLUIZ FERNANDO FERRAZ DA SILVA
hcfmusp.contributor.author-fmusphcMARIA NOTOMI SATO
hcfmusp.contributor.author-fmusphcVALERIA AOKI
hcfmusp.description.beginpage72
hcfmusp.description.endpage79
hcfmusp.description.issue1
hcfmusp.description.volume99
hcfmusp.origemWOS
hcfmusp.origem.dimensionspub.1164166735
hcfmusp.origem.pubmed37730501
hcfmusp.origem.scopus2-s2.0-85171363995
hcfmusp.origem.wosWOS:001153969600001
hcfmusp.publisher.cityNEW YORKeng
hcfmusp.publisher.countryUSAeng
hcfmusp.relation.referenceAoki V, 2019, AN BRAS DERMATOL, V94, pS67, DOI 10.1590/abd1806-4841.2019940210eng
hcfmusp.relation.referenceBatista DIS, 2015, J EUR ACAD DERMATOL, V29, P1091, DOI 10.1111/jdv.12753eng
hcfmusp.relation.referenceBilsborough J, 2006, J ALLERGY CLIN IMMUN, V117, P418, DOI 10.1016/j.jaci.2005.10.046eng
hcfmusp.relation.referenceBissonnette R, 2019, J ALLERGY CLIN IMMUN, V144, P1274, DOI 10.1016/j.jaci.2019.06.047eng
hcfmusp.relation.referenceBrenninkmeijer EEA, 2010, BRIT J DERMATOL, V163, P823, DOI 10.1111/j.1365-2133.2010.09858.xeng
hcfmusp.relation.referenceBrunner PM, 2018, J ALLERGY CLIN IMMUN, V141, P2094, DOI 10.1016/j.jaci.2018.02.040eng
hcfmusp.relation.referenceCevikbas F, 2014, J ALLERGY CLIN IMMUN, V133, P448, DOI 10.1016/j.jaci.2013.10.048eng
hcfmusp.relation.referenceEdukulla R, 2015, J BIOL CHEM, V290, P13510, DOI 10.1074/jbc.M114.622126eng
hcfmusp.relation.referenceFeld M, 2016, J ALLERGY CLIN IMMUN, V138, P500, DOI 10.1016/j.jaci.2016.02.020eng
hcfmusp.relation.referenceFurue M, 2018, ALLERGY, V73, P29, DOI 10.1111/all.13239eng
hcfmusp.relation.referenceFurue M, 2017, ALLERGOL INT, V66, P398, DOI 10.1016/j.alit.2016.12.002eng
hcfmusp.relation.referenceGittler JK, 2012, J ALLERGY CLIN IMMUN, V130, P1344, DOI 10.1016/j.jaci.2012.07.012eng
hcfmusp.relation.referenceGuttman-Yassky E, 2019, J ALLERGY CLIN IMMUN, V143, P155, DOI 10.1016/j.jaci.2018.08.022eng
hcfmusp.relation.referenceLima LPS, 2021, thesiseng
hcfmusp.relation.referenceLivak KJ, 2001, METHODS, V25, P402, DOI 10.1006/meth.2001.1262eng
hcfmusp.relation.referenceMiake S, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20164053eng
hcfmusp.relation.referenceMortz CG, 2015, ALLERGY, V70, P836, DOI 10.1111/all.12619eng
hcfmusp.relation.referenceNiebuhr M, 2010, J ALLERGY CLIN IMMUN, V126, P1176, DOI 10.1016/j.jaci.2010.07.041eng
hcfmusp.relation.referenceNobbe S, 2012, ACTA DERM-VENEREOL, V92, P24, DOI 10.2340/00015555-1191eng
hcfmusp.relation.referenceNoda S, 2015, J ALLERGY CLIN IMMUN, V136, P1254, DOI 10.1016/j.jaci.2015.08.015eng
hcfmusp.relation.referenceOGAWA H, 1992, PEDIATR DERMATOL, V9, P383, DOI 10.1111/j.1525-1470.1992.tb00638.xeng
hcfmusp.relation.referenceOrfali RL, 2013, REV ASSOC MED BRAS, V59, P270, DOI 10.1016/j.ramb.2012.12.004eng
hcfmusp.relation.referencePagliari C, 2011, MICROB PATHOGENESIS, V50, P263, DOI 10.1016/j.micpath.2010.12.008eng
hcfmusp.relation.referencePrasad K, 2012, J MED SYST, V36, P2621, DOI 10.1007/s10916-011-9737-7eng
hcfmusp.relation.referenceRoekevisch E, 2020, J EUR ACAD DERMATOL, V34, P1545, DOI 10.1111/jdv.16164eng
hcfmusp.relation.referenceSamorano LP, 2021, J DTSCH DERMATOL GES, V19, P294, DOI 10.1111/ddg.14414eng
hcfmusp.relation.referenceSchram ME, 2011, J ALLERGY CLIN IMMUN, V128, P353, DOI 10.1016/j.jaci.2011.03.024eng
hcfmusp.relation.referenceSimpson EL, 2017, J AM ACAD DERMATOL, V77, P623, DOI 10.1016/j.jaad.2017.06.042eng
hcfmusp.relation.referenceSonkoly E, 2006, J ALLERGY CLIN IMMUN, V117, P411, DOI 10.1016/j.jaci.2005.10.033eng
hcfmusp.relation.referenceWerfel T, 2021, J DTSCH DERMATOL GES, V19, P151, DOI 10.1111/ddg.14371eng
hcfmusp.relation.referenceWilson SR, 2013, CELL, V155, P285, DOI 10.1016/j.cell.2013.08.057eng
hcfmusp.relation.referenceWollenberg A, 2018, J EUR ACAD DERMATOL, V32, P850, DOI 10.1111/jdv.14888eng
hcfmusp.scopus.lastupdate2024-04-12
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