CAROTID ATHEROSCLEROSIS IN BRAZILIAN WOMEN WITH LOW FRAMINGHAM RISK SCORE

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorBARROS, Isly Lucena de
dc.contributor.authorCOSTA, Laura
dc.contributor.authorSOUZA, Ana Paula Tavares
dc.contributor.authorVERAS, Pedro
dc.contributor.authorFANTATO, Daniela
dc.contributor.authorBEZERRA, Bento
dc.contributor.authorMORAIS, Natanael
dc.contributor.authorNOVAES, Moacir
dc.contributor.authorNICOLAU, Jose Carlos
dc.date.accessioned2013-10-11T21:17:44Z
dc.date.available2013-10-11T21:17:44Z
dc.date.issued2012
dc.description.abstractBackground Cardiovascular disease is the leading cause of death among Brazilian women, particularly those from north and northeast region. The Framingham risk score (FRS) is a currently tool to identify women at increased risk for cardiovascular disease and determine appropriate primary prevention therapy. However, there are several clinical limitations for its use. The main purpose of the present study was to evaluate the prevalence of carotid atherosclerosis by carotid ultrasound in a population of peri- and post-menopausal women with low and very low risk of events according to the FRS. Methods We studied 806 healthy peri- and post-menopausal women, 45 to 65 years-old (mean age 54.3±5.3 years), with absence of known cardiovascular disease, and without hormone therapy utilization. This sample was representative of poor class women from Recife, one of the Brazilian Northeastern state capitals. From the overall population we selected 765 women with completed data, classified at very low (10 years event rate ≤ 5%; n=683) or not very low risk (≥6%; n=82). B-mode ultrasound was utilized for carotid evaluations. Presence of carotid atherosclerosis was defined as either the presence of plaque and/or carotid intima-media thickness (CIMT) ≥ 75th percentile. Results The prevalence of carotid atherosclerosis in the overall population was 30% (230/765), being of 28,5% (195/683) in the very low FRS subset, and of 42,7% (35/82) in the population with higher FRS risk. Difference between groups was 14,2% (95%CI 2.77 to 26.1, P-value=0,0116). Conclusions In this sample of asymptomatic peri- and post-menopausal women the prevalence of carotid atherosclerosis was surprisingly high, and increased significantly between very low and higher FRS. ACC Moderated Poster Contributions McCormick Place South, Hall A Sunday, March 25, 2012, 11:00 a.m.-Noon Session Title: Prevention: Clinical: Updates in Gender Related Research Abstract Category: 9. Prevention: Clinical Presentation Number: 1183-240
dc.description.conferencedateMAR 24-27, 2012
dc.description.conferencelocalChicago - IL, EUA
dc.description.conferencename61st Annual Scientific Session and Expo of the American-College-of-Cardiology (ACC)
dc.description.indexMEDLINE
dc.identifier.citationJOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, v.59, n.13, suppl.S, p.E1741-E1741, 2012
dc.identifier.issn0735-1097
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/2804
dc.language.isoeng
dc.publisherELSEVIER SCIENCE INC
dc.relation.ispartofJournal of the American College of Cardiology
dc.rightsrestrictedAccess
dc.rights.holderCopyright ELSEVIER SCIENCE INC
dc.subject.wosCardiac & Cardiovascular Systems
dc.titleCAROTID ATHEROSCLEROSIS IN BRAZILIAN WOMEN WITH LOW FRAMINGHAM RISK SCORE
dc.typeconferenceObject
dc.type.categorymeeting abstract
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.contributor.author-fmusphcISLY MARIA LUCENA DE BARROS
hcfmusp.contributor.author-fmusphcNATANAEL VILELA MORAIS
hcfmusp.contributor.author-fmusphcJOSE CARLOS NICOLAU
hcfmusp.description.beginpageE1741
hcfmusp.description.endpageE1741
hcfmusp.description.issue13
hcfmusp.description.issuesuppl S
hcfmusp.description.volume59
hcfmusp.origemWOS
hcfmusp.origem.wosWOS:000302326701852
hcfmusp.publisher.cityNEW YORK
hcfmusp.publisher.countryUSA
relation.isAuthorOfPublication04e013e7-59ca-4dbf-b2d8-2297bfd95444
relation.isAuthorOfPublication5868b569-aac3-4c60-b58a-18b534449de9
relation.isAuthorOfPublication2ff39bf2-b5fb-4568-a932-b466563074d8
relation.isAuthorOfPublication.latestForDiscovery04e013e7-59ca-4dbf-b2d8-2297bfd95444
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Comunicações em Eventos - FM/MCP
Comunicações em Eventos - HC/InCor
Comunicações em Eventos - LIM/11