Low-Intensity Pulsed Ultrasound Accelerates Healing in Rat Calcaneus Tendon Injuries

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorJEREMIAS JUNIOR, Sergio Luiz
dc.contributor.authorCAMANHO, Gilberto Luis
dc.contributor.authorBASSIT, Ana Cristina Ferreira
dc.contributor.authorFORGAS, Andrea
dc.contributor.authorINGHAM, Sheila J. M.
dc.contributor.authorABDALLA, Rene Jorge
dc.date.accessioned2017-11-27T16:33:06Z
dc.date.available2017-11-27T16:33:06Z
dc.date.issued2011
dc.description.abstractSTUDY DESIGN: Controlled laboratory study. OBJECTIVE: To evaluate the effect of low-intensity therapeutic ultrasound on the murine calcaneus tendon healing process. BACKGROUND: Therapeutic ultrasound promotes formation and maturation of scar tissue. METHODS: Calcaneus tendon tenotomy and tenorrhaphy was performed on 28 Wistar rats. After the procedure, the animals were randomly divided into 2 groups. The animals in the experimental group received a 5-minute ultrasound application, once a day, at a frequency of 1 MHz, a spatial average temporal average intensity of 0.1 W/cm(2), and a spatial average intensity of 0.52 W/cm(2) at a 16-Hz frequency pulse mode (duty cycle, 20%). Data for the injured side were normalized in relation to the data from the contralateral healthy calcaneus tendon (relative values). The animals in the control group received sham treatment. After a 28-day treatment period, the animals were sacrificed and their tendons surgically removed and subjected to mechanical stress testing. The parameters analyzed were cross-sectional area (mm(2)), ultimate load (N), tensile strength (MPa), and energy absorption (mJ). RESULTS: A significant difference between groups was found for the relative values of ultimate load and tensile strength. The mean +/- SD ultimate load of the control group was -3.5% +/- 32.2% compared to 33.3% +/- 26.8% for the experimental group (P = .005). The mean tensile strength of the control group was -47.7% +/- 19.5% compared to -28.1% +/- 24.1% for the experimental group (P = .019). No significant difference was found in cross-sectional area and energy absorption. CONCLUSION: Low-intensity pulsed ultrasound produced by a conventional therapeutic ultrasound unit can positively influence the calcaneus tendon healing process in rats. J Ort hop Sports Phys Ther 2011;41(7):526-531, Epub 2 February 2011. doi:10.2519/jospt.2011.3468
dc.description.indexMEDLINE
dc.identifier.citationJOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY, v.41, n.7, p.526-531, 2011
dc.identifier.doi10.2519/jospt.2011.3468
dc.identifier.issn0190-6011
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/23264
dc.language.isoeng
dc.publisherJ O S P T,
dc.relation.ispartofJournal of Orthopaedic & Sports Physical Therapy
dc.rightsrestrictedAccess
dc.rights.holderCopyright J O S P T,
dc.subjectbiomechanical testing
dc.subjectphysical agents
dc.subjecttherapeutic ultrasound
dc.subject.othertherapeutic ultrasound
dc.subject.otherin-vitro
dc.subject.othercollagen-synthesis
dc.subject.otherhuman fibroblasts
dc.subject.otherprotein-synthesis
dc.subject.otherrepair
dc.subject.otherproliferation
dc.subject.othergranulation
dc.subject.otherhemorrhage
dc.subject.otherexposure
dc.subject.wosOrthopedics
dc.subject.wosRehabilitation
dc.subject.wosSport Sciences
dc.titleLow-Intensity Pulsed Ultrasound Accelerates Healing in Rat Calcaneus Tendon Injuries
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalJEREMIAS JUNIOR, Sergio Luiz:Univ Sao Paulo, Sch Med, Dept Orthopaed Surg, Sao Paulo, Brazil
hcfmusp.author.externalINGHAM, Sheila J. M.:Fed Univ Sao Paulo UNIFESP EPM, Sch Med, Div Phys Med & Rehabil, Dept Orthopaed Surg, Sao Paulo, Brazil
hcfmusp.author.externalABDALLA, Rene Jorge:Heart Hosp, Sao Paulo, Brazil
hcfmusp.citation.scopus30
hcfmusp.contributor.author-fmusphcGILBERTO LUIS CAMANHO
hcfmusp.contributor.author-fmusphcANA CRISTINA FERREIRA BASSIT
hcfmusp.contributor.author-fmusphcANDREA FORGAS
hcfmusp.description.beginpage526
hcfmusp.description.endpage531
hcfmusp.description.issue7
hcfmusp.description.volume41
hcfmusp.origemWOS
hcfmusp.origem.pubmed21335926
hcfmusp.origem.scopus2-s2.0-79959980688
hcfmusp.origem.wosWOS:000292172300009
hcfmusp.publisher.cityALEXANDRIA
hcfmusp.publisher.countryUSA
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