Exercise training induces alteration of clock genes and myokines expression in tumor-bearing mice

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorTEIXEIRA, Alexandre Abilio de Souza
dc.contributor.authorBIONDO, Luana
dc.contributor.authorSILVEIRA, Loreana Sanches
dc.contributor.authorLIMA, Edson A.
dc.contributor.authorDINIZ, Tiego A.
dc.contributor.authorLIRA, Fabio Santos
dc.contributor.authorSEELAENDER, Marilia
dc.contributor.authorNETO, Jose Cesar Rosa
dc.date.accessioned2024-04-05T19:26:55Z
dc.date.available2024-04-05T19:26:55Z
dc.date.issued2023
dc.description.abstractTo investigate the impact of different exercise training schedules (following a fixed schedule or at random times of the day) on clock genes and myokine expression patterns in the skeletal muscle of tumor-bearing mice. Mice were divided into three groups: tumor (LLC), tumor + exercise training (LLC + T) always performed at the same time of the day (ZT2) and exercise training at random times of the day (ZTAlt). Mice were inoculated subcutaneously with Lewis lung carcinoma cells. The gastrocnemius muscle was dissected and the clock gene expression (Clock/Per1/Per2/Per3/Rev-Erb alpha/GAPDH) was investigated by quantitative reverse transcription polymerase chain reaction with SYBR (R) Green. Myokine content in muscle (tumour necrosis factor alpha/IL-10/IL-4) was assessed by enzyme-linked immunosorbent assay. At the end of the protocol, the trained groups showed a reduction in total weight, when compared to Lewis lung carcinoma. Tumor weight was lower in the LLC + T (ZTAlt), when compared to LLC. Clock gene mRNA expression showed a significant increase for ZT20 in the groups that performed physical exercise at LLC + T (ZTAlt), when compared with LLC. The Per family showed increased mRNA expression in ZT4 in both trained mice groups, when compared with LLC. LLC + T (ZTAlt) presented reduction of the expression of anti-inflammatory myokines (Il-10/IL-4) during the night, compared with LLC + T(ZT2). Exercise training is able to induce marked modification of clock gene expression and of the production of myokines, in a way that is dependent on schedule exercise training strategy. Taken together, the results show that exercise is a potent Zeitgeber and may thus contribute to change clock genes expression and myokines that are able to reduce the tumor weight.eng
dc.description.indexMEDLINE
dc.description.indexPubMed
dc.description.indexScopus
dc.description.indexDimensions
dc.description.indexWoS
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado deSao Paulo [2015/16777-0, 2018/24187-6, 2018/19678-0, 2019/09854-9, 2020/07765-6, 2021/00352-0]
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoalde Nivel Superior
dc.description.sponsorshipConselho Nacional deDesenvolvimento Cientifico e Tecnologico
dc.identifier.citationCELL BIOCHEMISTRY AND FUNCTION, v.41, n.8, p.1383-1394, 2023
dc.identifier.doi10.1002/cbf.3872
dc.identifier.eissn1099-0844
dc.identifier.issn0263-6484
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/58728
dc.language.isoeng
dc.publisherWILEYeng
dc.relation.ispartofCell Biochemistry and Function
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright WILEYeng
dc.subjectcancereng
dc.subjectcircadian rhythmseng
dc.subjecthealtheng
dc.subjectmuscleeng
dc.subjectphysical exerciseeng
dc.subject.othercircadian clockeng
dc.subject.otherrev-erbeng
dc.subject.otherbreast-cancereng
dc.subject.othertranscriptioneng
dc.subject.otherrhythmseng
dc.subject.otherriskeng
dc.subject.otherentrainmenteng
dc.subject.otherenvironmenteng
dc.subject.otherphysiologyeng
dc.subject.otherhallmarkseng
dc.subject.wosBiochemistry & Molecular Biologyeng
dc.subject.wosCell Biologyeng
dc.titleExercise training induces alteration of clock genes and myokines expression in tumor-bearing miceeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryPortugal
hcfmusp.affiliation.countryisopt
hcfmusp.author.externalTEIXEIRA, Alexandre Abilio de Souza:Univ Sao Paulo, Inst Biomed Sci, Dept Cell & Dev Biol, Immunometabolism Res Grp, Sao Paulo, SP, Brazil; Univ Sao Paulo, Inst Biomed Sci, Immunometab Res Grp, Av Lineu Prestes 1524, BR-05508900 Sao Paulo, SP, Brazil
hcfmusp.author.externalBIONDO, Luana:Univ Sao Paulo, Inst Biomed Sci, Dept Cell & Dev Biol, Immunometabolism Res Grp, Sao Paulo, SP, Brazil
hcfmusp.author.externalSILVEIRA, Loreana Sanches:Univ Sao Paulo, Inst Biomed Sci, Dept Cell & Dev Biol, Immunometabolism Res Grp, Sao Paulo, SP, Brazil
hcfmusp.author.externalLIMA, Edson A.:Univ Sao Paulo, Inst Biomed Sci, Dept Cell & Dev Biol, Immunometabolism Res Grp, Sao Paulo, SP, Brazil
hcfmusp.author.externalDINIZ, Tiego A.:Univ Sao Paulo, Inst Biomed Sci, Dept Cell & Dev Biol, Immunometabolism Res Grp, Sao Paulo, SP, Brazil
hcfmusp.author.externalLIRA, Fabio Santos:Univ Estadual Paulista UNESP, Dept Phys Educ, Postgrad Program Movement Sci, Exercise & Immunometabolism Res Grp, Presidente Prudente, SP, Brazil; Univ Coimbra, CIDAF, Coimbra, Portugal
hcfmusp.author.externalNETO, Jose Cesar Rosa:Univ Sao Paulo, Inst Biomed Sci, Dept Cell & Dev Biol, Immunometabolism Res Grp, Sao Paulo, SP, Brazil
hcfmusp.citation.scopus0
hcfmusp.contributor.author-fmusphcMARILIA CERQUEIRA LEITE SEELAENDER
hcfmusp.description.beginpage1383
hcfmusp.description.endpage1394
hcfmusp.description.issue8
hcfmusp.description.volume41
hcfmusp.origemWOS
hcfmusp.origem.dimensionspub.1165224025
hcfmusp.origem.pubmed37877577
hcfmusp.origem.scopus2-s2.0-85174609373
hcfmusp.origem.wosWOS:001091725700001
hcfmusp.publisher.cityHOBOKENeng
hcfmusp.publisher.countryUSAeng
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