Randomized Sham Controlled Double-blind Trial of Repetitive Transcranial Magnetic Stimulation for Adults With Severe Tourette Syndrome

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorLANDEROS-WEISENBERGER, Angeli
dc.contributor.authorMANTOVANI, Antonio
dc.contributor.authorMOTLAGH, Maria G.
dc.contributor.authorALVARENGA, Pedro Gomes de
dc.contributor.authorKATSOVICH, Liliya
dc.contributor.authorLECKMAN, James F.
dc.contributor.authorLISANBY, Sarah H.
dc.date.accessioned2015-10-26T16:33:34Z
dc.date.available2015-10-26T16:33:34Z
dc.date.issued2015
dc.description.abstractBackground: A small proportion of individuals with Tourette syndrome (TS) have a lifelong course of illness that fails to respond to conventional treatments. Open label studies have suggested that low frequency (1-Hz) repetitive transcranial magnetic stimulation (rTMS) targeting the supplementary motor area (SMA) may be effective in reducing tic severity. Objective/Hypothesis: To examine the efficacy of rTMS over the SMA for TS in a randomized double-blind sham-controlled trial (RCT). Methods: We conducted a two-site RCT-rTMS with 20 adults with severe TS for 3 weeks. Treatment consisted of 15 sessions (1-Hz; 30 min; 1800 pulses per day) of active or sham rTMS at 110% of the motor threshold over the SMA. A subsequent 3 week course of active rTMS treatment was offered. Results: Of the 20 patients (16 males; mean age of 33.7 + 12.2 years), 9 received active and 11 received sham rTMS. After 3 weeks, patients receiving active rTMS showed on average a 17.3% reduction in the YGTSS total tic score compared to a 13.2% reduction in those receiving sham rTMS, resulting in no statistically significant reduction in tic severity (P = 0.27). An additional 3 week open label active treatment for those patients (n = 7) initially randomized to active rTMS resulted in a significant overall 29.7% reduction in tic severity compared to baseline (P = 0.04). Conclusion: This RCT did not demonstrate efficacy of 3-week SMA-targeted low frequency rTMS in the treatment of severe adult TS. Further studies using longer or alternative stimulation protocols are warranted.
dc.description.indexMEDLINE
dc.description.sponsorshipTourette Syndrome Association
dc.description.sponsorshipNational Institute of Mental Health [R21MH082323 [NCT00529308]]
dc.description.sponsorshipEchlin Foundation
dc.description.sponsorshipRembrandt Foundation
dc.identifier.citationBRAIN STIMULATION, v.8, n.3, p.574-581, 2015
dc.identifier.doi10.1016/j.brs.2014.11.015
dc.identifier.eissn1876-4754
dc.identifier.issn1935-861X
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/11859
dc.language.isoeng
dc.publisherELSEVIER SCIENCE INC
dc.relation.ispartofBrain Stimulation
dc.rightsrestrictedAccess
dc.rights.holderCopyright ELSEVIER SCIENCE INC
dc.subjectTourette syndrome
dc.subjectTranscranial
dc.subjectMagnetic stimulation
dc.subjectRandomized controlled trial
dc.subject.otherobsessive-compulsive disorder
dc.subject.othersupplementary motor area
dc.subject.other1 hz rtms
dc.subject.othereuropean clinical guidelines
dc.subject.othercerebral-blood-flow
dc.subject.othertic disorders
dc.subject.otherfunctional mri
dc.subject.otherscale
dc.subject.otherinhibition
dc.subject.othercortex
dc.subject.wosClinical Neurology
dc.subject.wosNeurosciences
dc.titleRandomized Sham Controlled Double-blind Trial of Repetitive Transcranial Magnetic Stimulation for Adults With Severe Tourette Syndrome
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryisous
hcfmusp.author.externalLANDEROS-WEISENBERGER, Angeli:Yale Univ, Sch Med, Ctr Child Study, New Haven, CT 06520 USA
hcfmusp.author.externalMANTOVANI, Antonio:CUNY, Sophie Davis Sch Biomed Educ, Dept Physiol Pharmacol & Neurosci, New York, NY USA; Columbia Univ, New York State Psychiat Inst, Dept Psychiat, Div Expt Therapeut, New York, NY USA
hcfmusp.author.externalMOTLAGH, Maria G.:Yale Univ, Sch Med, Ctr Child Study, New Haven, CT 06520 USA; Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06520 USA
hcfmusp.author.externalKATSOVICH, Liliya:Yale Univ, Sch Med, Ctr Child Study, New Haven, CT 06520 USA
hcfmusp.author.externalLECKMAN, James F.:Yale Univ, Sch Med, Ctr Child Study, New Haven, CT 06520 USA
hcfmusp.author.externalLISANBY, Sarah H.:Duke Univ, Dept Psychiat & Behav Sci, Durham, NC USA
hcfmusp.citation.scopus61
hcfmusp.contributor.author-fmusphcPEDRO GOMES DE ALVARENGA
hcfmusp.description.beginpage574
hcfmusp.description.endpage581
hcfmusp.description.issue3
hcfmusp.description.volume8
hcfmusp.origemWOS
hcfmusp.origem.pubmed25912296
hcfmusp.origem.scopus2-s2.0-84941599216
hcfmusp.origem.wosWOS:000355772300019
hcfmusp.publisher.cityNEW YORK
hcfmusp.publisher.countryUSA
hcfmusp.relation.referenceAdler LA, 2008, J ATTEN DISORD, V11, P711, DOI 10.1177/1087054707308503
hcfmusp.relation.referenceAdler LA, 2012, J CHILD ADOL PSYCHOP, V22, P238, DOI 10.1089/cap.2011.0062
hcfmusp.relation.referenceBerardelli A, 2003, J NEUROL, V250, P781, DOI 10.1007/s00415-003-1102-4
hcfmusp.relation.referenceBloch Michael H, 2006, Arch Pediatr Adolesc Med, V160, P65, DOI 10.1001/archpedi.160.1.65
hcfmusp.relation.referenceBohlhalter S, 2006, BRAIN, V129, P2029, DOI 10.1093/brain/awl050
hcfmusp.relation.referenceBrighina F, 2005, EXP BRAIN RES, V161, P34, DOI 10.1007/s00221-004-2042-7
hcfmusp.relation.referenceCaparelli Ec, 2012, Open Neuroimag J, V6, P69, DOI 10.2174/1874440001206010069
hcfmusp.relation.referenceChae Jeong-Ho, 2004, Cogn Behav Neurol, V17, P109, DOI 10.1097/01.wnn.0000116253.78804.3a
hcfmusp.relation.referenceCui YH, 2014, FRONT HUM NEUROSCI, V7, DOI 10.3389/fnhum.2013.00913
hcfmusp.relation.referenceCunnington R, 2005, HUM MOVEMENT SCI, V24, P644, DOI 10.1016/j.humov.2005.10.001
hcfmusp.relation.referenceFierro B, 2003, NEUROLOGY, V61, P1446
hcfmusp.relation.referenceFitzgerald PB, 2002, CLIN NEUROPHYSIOL, V113, P1136, DOI 10.1016/S1388-2457(02)00145-1
hcfmusp.relation.referenceFranzkowiak S, 2010, MOVEMENT DISORD, V25, P1960, DOI 10.1002/mds.23186
hcfmusp.relation.referenceGoetz SM, 2013, NEUROPSYCHOPHARMACOL, V38, pS246
hcfmusp.relation.referenceGOODMAN WK, 1989, ARCH GEN PSYCHIAT, V46, P1006
hcfmusp.relation.referenceGuy W. National Institute of Mental Health (U.S.), 1976, ECDEU ASSESSMENT MAN
hcfmusp.relation.referenceHAMILTON M, 1959, BRIT J MED PSYCHOL, V32, P50
hcfmusp.relation.referenceHAMILTON M, 1960, J NEUROL NEUROSUR PS, V23, P56, DOI 10.1136/jnnp.23.1.56
hcfmusp.relation.referenceHampson M, 2009, BIOL PSYCHIAT, V65, P594, DOI 10.1016/j.biopsych.2008.11.012
hcfmusp.relation.referenceJeon S, 2013, CONTEMP CLIN TRIALS, V36, P414, DOI [10.1016/j.cct.2013.08.012, 10.1016/j.cct2013.08.012]
hcfmusp.relation.referenceJung J, 2013, NEUROSCI BIOBEHAV R, V37, P1016, DOI 10.1016/j.neubiorev.2012.08.009
hcfmusp.relation.referenceKeel JC, 2001, CLIN NEUROPHYSIOL, V112, P720, DOI 10.1016/S1388-2457(00)00518-6
hcfmusp.relation.referenceKwon HJ, 2011, NEUROSCI LETT, V492, P1, DOI 10.1016/j.neulet.2011.01.007
hcfmusp.relation.referenceLe K, 2013, J CLIN NEUROSCI, V20, P251, DOI 10.1016/j.jocn.2012.01.049
hcfmusp.relation.referenceLeckman JF, 2013, TOURETTE SYNDROME, P3
hcfmusp.relation.referenceLECKMAN JF, 1989, J AM ACAD CHILD PSY, V28, P566, DOI 10.1097/00004583-198907000-00015
hcfmusp.relation.referenceLEVINE J, 1986, PSYCHOPHARMACOL BULL, V22, P343
hcfmusp.relation.referenceLin HQ, 2002, J AM ACAD CHILD PSY, V41, P1070, DOI 10.1097/01.CHI.0000020264.43550.6C
hcfmusp.relation.referenceLiu YX, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0063447
hcfmusp.relation.referenceMantovani A, 2006, INT J NEUROPSYCHOPH, V9, P95, DOI 10.1017/S1461145705005729
hcfmusp.relation.referenceMantovani A, 2007, CLIN NEUROPHYSIOL, V118, P2314, DOI 10.1016/j.clinph.2007.07.011
hcfmusp.relation.referenceMcGuire JF, 2014, J PSYCHIATR RES, V50, P106, DOI 10.1016/j.jpsychires.2013.12.009
hcfmusp.relation.referenceMuller-Vahl KR, 2011, EUR CHILD ADOLES PSY, V20, P209, DOI 10.1007/s00787-011-0166-4
hcfmusp.relation.referenceMuller-Vahl KR, 2013, NEUROSCI BIOBEHAV R, V37, P1178, DOI 10.1016/j.neubiorev.2012.09.012
hcfmusp.relation.referenceMunchau A, 2002, NEUROLOGY, V59, P1789
hcfmusp.relation.referenceObeso I, 2013, BRAIN STIMUL, V6, P769, DOI 10.1016/j.brs.2013.02.002
hcfmusp.relation.referenceOrth J, 2013, TOURETTE SYNDROME, P221
hcfmusp.relation.referenceOrth M, 2009, J PSYCHOSOM RES, V67, P591, DOI 10.1016/j.jpsychores.2009.07.014
hcfmusp.relation.referenceOrth M, 2005, CLIN NEUROPHYSIOL, V116, P764, DOI 10.1016/j.clinph.2004.10.003
hcfmusp.relation.referencePaulus W, 2008, BRAIN STIMUL, V1, P151, DOI 10.1016/j.brs.2008.06.002
hcfmusp.relation.referencePeterchev AV, 2013, CLIN NEUROPHYSIOL, V124, P1364, DOI 10.1016/j.clinph.2013.01.011
hcfmusp.relation.referenceRobertson MM, 2000, EUR CHILD ADOLES PSY, V9, P60
hcfmusp.relation.referenceRoessner V, 2013, TOURETTE SYNDROME, P524
hcfmusp.relation.referenceRoessner V, 2011, EUR CHILD ADOLES PSY, V20, P153, DOI 10.1007/s00787-011-0165-5
hcfmusp.relation.referenceRossi S, 2007, CLIN NEUROPHYSIOL, V118, P709, DOI 10.1016/j.clinph.2006.11.005
hcfmusp.relation.referenceSalatino A, 2014, BRAIN STIMUL, V7, P341, DOI 10.1016/j.brs.2014.01.002
hcfmusp.relation.referenceScahill L, 2003, NEUROLOGY, V60, P1130
hcfmusp.relation.referenceScahill L, 2001, AM J PSYCHIAT, V158, P1067, DOI 10.1176/appi.ajp.158.7.1067
hcfmusp.relation.referenceServello D, 2011, ACTA NEUROCHIR, V153, P629, DOI 10.1007/s00701-010-0851-y
hcfmusp.relation.referenceSiniatchkin M, 2007, HEADACHE, V47, P364, DOI 10.1111/j.1526-4610.2007.00727.x
hcfmusp.relation.referenceSpeer AM, 2003, BIOL PSYCHIAT, V54, P826, DOI 10.1016/S0006-3223(03)00324-X
hcfmusp.relation.referenceSuppa A, 2011, MOVEMENT DISORD, V26, P1703, DOI 10.1002/mds.23706
hcfmusp.relation.referenceTeepker M, 2010, CEPHALALGIA, V30, P137, DOI 10.1111/j.1468-2982.2009.01911.x
hcfmusp.relation.referenceWiesendanger M, 2006, PROG NEUROBIOL, V78, P304, DOI 10.1016/j.pneurobio.2006.02.004
hcfmusp.relation.referenceWoods DW, 2005, J DEV BEHAV PEDIATR, V26, P397, DOI 10.1097/00004703-200512000-00001
hcfmusp.relation.referenceWu SW, 2014, BRAIN STIMUL, V7, P212, DOI 10.1016/j.brs.2013.10.005
hcfmusp.relation.referenceWu SW, 2012, BRAIN STIMUL, V5, P315, DOI 10.1016/j.brs.2011.04.001
hcfmusp.relation.referenceZiemann U, 1997, AM J PSYCHIAT, V154, P1277
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