Effect of maxillary alveolar reconstruction on nasal symmetry of cleft lip and palate patients: A study comparing iliac crest bone graft and recombinant human bone morphogenetic protein-2

Imagem de Miniatura
Arquivos
art_ALONSO_Effect_of_maxillary_alveolar_reconstruction_on_nasal_symmetry_2014.PDF (585.13 KB)
Citações na Scopus
31
Tipo de produção
article
Data de publicação
2014
DOI
Scopus
Web of Science
Título da Revista
ISSN da Revista
Título do Volume
Editora
ELSEVIER SCI LTD
Autores
DENADAI, Rafael
RAPOSO-AMARAL, Cassio Eduardo
Citação
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY, v.67, n.9, p.1201-1208, 2014
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Background: Recombinant human bone morphogenetic protein (rhBMP)-2 has been used in some craniofacial centers worldwide. However, its influence on nasal morphology is unknown. Thus, the objective of this investigation was to assess the effect of maxillary alveolar reconstruction on nasal position and symmetry in unilateral complete cleft lip patients who underwent traditional iliac crest bone grafting transferring versus reconstruction using rhBMP-2. Methods: Nineteen unilateral complete cleft lip patients were randomly divided into two groups. In group 1, patients underwent traditional iliac crest bone grafting transferring (n = 11) and in group 2, patients underwent alveolar reconstruction using collagen matrix with lyophilized rhBMP-2 (n = 8). Computerized tomography (CT) imaging was performed preoperatively and at 6 months postoperatively using a previously standardized protocol. Linear distances using anatomic landmarks were performed using tridimensional CT data reformatted by the OsiriX (R) software. Quantitative and qualitative measurements to assess intra-and inter-group nasal position modifications were performed. Results: Intra-group pre- and postoperative comparisons showed significant differences (p < 0.05) in two linear measurements of group 1, while group 2 did not present a difference (p > 0.05). Group 2 presented significant postoperative enhancement (p < 0.05) in the quantitative nasal symmetry in one measurement. Qualitative analysis showed postoperative nasal symmetry enhancement in 75% of the measurements of group 2 and 36% of group 1. There was no statistically significant difference in the inter-group comparisons. Conclusions: Our study demonstrated that both groups showed similar effect on nasal symmetry.
Palavras-chave
Alveolar cleft repair, Recombinant human bone morphogenetic protein, rhBMP-2, Iliac crest bone graft, Nasal symmetry, Nasal position
URI
https://observatorio.fm.usp.br/handle/OPI/8276
Referências
  1. Al-Omari I, 2005, CLEFT PALATE-CRAN J, V42, P145, DOI 10.1597/02-149.1
  2. Alonso N, 2010, TISSUE ENG PART C-ME, V16, P1183, DOI 10.1089/ten.TEC.2009.0824
  3. Baeyens W, 2006, SCAND J PLAST RECONS, V40, P345, DOI 10.1080/02844310601029928
  4. Bajaj AK, 2003, J CRANIOFAC SURG, V14, P840, DOI 10.1097/00001665-200311000-00005
  5. Baykul T, 2010, J CRANIOFAC SURG, V21, P1512, DOI 10.1097/SCS.0b013e3181ebe646
  6. Bilwatsch S, 2006, J CRANIO MAXILL SURG, V34, P253, DOI 10.1016/j.jcms.2006.03.001
  7. Canan LW, 2012, J CRANIOFAC SURG, V23, P1627, DOI 10.1097/SCS.0b013e31825c75ba
  8. Chang CS, 2010, PLAST RECONSTR SURG, V126, P1276, DOI 10.1097/PRS.0b013e3181ec21e4
  9. Cooper GM, 2010, PLAST RECONSTR SURG, V125, P1685, DOI 10.1097/PRS.0b013e3181cb63a3
  10. Dickinson BP, 2008, PLAST RECONSTR SURG, V121, P209, DOI 10.1097/01.prs.0000293870.64781.12
  11. Engstrand T, 2012, J CRANIOFAC SURG, V23, P239, DOI 10.1097/SCS.0b013e318241c0f4
  12. Fallucco MA, 2009, J CRANIOFAC SURG, V20, P1759, DOI 10.1097/SCS.0b013e3181b5d08e
  13. Farkas LG, 1994, ANTHOPOMETRY HEAD FA
  14. Francis CS, 2013, PLAST RECONSTR SURG, V131, P1107, DOI 10.1097/PRS.0b013e3182865dfb
  15. Freeman AK, 2013, J PLAST RECONSTR AES, V66, P506, DOI 10.1016/j.bjps.2012.12.001
  16. FRIEDE H, 1982, SCAND J PLAST RECONS, V16, P41
  17. Govender S, 2002, J BONE JOINT SURG AM, V84A, P2123
  18. Grisius TM, 2006, J CRANIOFAC SURG, V17, P468, DOI 10.1097/00001665-200605000-00013
  19. Haddock NT, 2012, PLAST RECONSTR SURG, V129, P740, DOI 10.1097/PRS.0b013e3182402e8e
  20. Herford AS, 2007, J ORAL MAXIL SURG, V65, P2136, DOI 10.1016/j.jams.2007.06.670
  21. Kim G, 2012, J DIGIT IMAGING, V25, P486, DOI 10.1007/s10278-012-9458-6
  22. Kim SW, 2012, J PLAST RECONSTR AES, V65, P558, DOI 10.1016/j.bjps.2011.11.046
  23. Krimmel M, 2011, J ORAL MAXIL SURG, V69, P80, DOI 10.1016/j.joms.2010.03.009
  24. Krimmel M, 2006, CLEFT PALATE-CRAN J, V43, P350
  25. Li JT, 2011, J PLAST RECONSTR AES, V64, P1436, DOI 10.1016/j.bjps.2011.06.022
  26. Mannion RJ, 2011, SPINE J, V11, P527, DOI 10.1016/j.spinee.2010.07.005
  27. Mesfin A, 2013, J BONE JOINT SURG AM, V95A, P1546, DOI 10.2106/JBJS.L.01730
  28. Meyer S, 2013, J PLAST SURG HAND SU, V47, P503, DOI 10.3109/2000656X.2013.789036
  29. Mulliken JB, 1999, PLAST RECONSTR SURG, V104, P1247, DOI 10.1097/00006534-199910000-00003
  30. Nagasao T, 2009, CLEFT PALATE-CRAN J, V46, P9, DOI 10.1597/07-169.1
  31. Nguyen PD, 2009, PLAST RECONSTR SURG, V124, P1829, DOI 10.1097/PRS.0b013e3181bf8024
  32. Rosset A, 2004, J DIGIT IMAGING, V17, P205, DOI 10.1007/s10278-004-1014-6
  33. Salyer KE, 2009, J CRANIOFAC SURG, V20, P1765, DOI 10.1097/SCS.0b013e3181b5d0af
  34. Salyer KE, 2004, CLIN PLAST SURG, V31, P191, DOI 10.1016/S0094-1298(03)00128-7
  35. Sander M, 2011, CLEFT PALATE-CRAN J, V48, P20, DOI 10.1597/09-007
  36. Shaw WC, 2001, J CRANIO MAXILL SURG, V29, P131, DOI 10.1054/jcms.2001.0217
  37. Tanikawa DYS, 2010, J CRANIOFAC SURG, V21, P1519, DOI 10.1097/SCS.0b013e3181ec087e
  38. Tomanová M, 1994, Acta Chir Plast, V36, P38
  39. vanderWal KGH, 1997, J ORAL MAXIL SURG, V55, P1089, DOI 10.1016/S0278-2391(97)90286-X
  40. Wu YL, 2010, J CRANIOFAC SURG, V21, P1904, DOI 10.1097/SCS.0b013e3181f4b18b

Coleções
Artigos e Materiais de Revistas Científicas - FM/MCG
Artigos e Materiais de Revistas Científicas - LIM/04