Fish oil supplementation and cancer cachexia

Carregando...
Imagem de Miniatura
Citações na Scopus
1
Tipo de produção
bookPart
Data de publicação
2016
Título da Revista
ISSN da Revista
Título do Volume
Editora
ELSEVIER INC.
Citação
Seelaender, M.. Fish oil supplementation and cancer cachexia. In: . FISH AND FISH OIL IN HEALTH AND DISEASE PREVENTION: ELSEVIER INC., 2016. p.283-289.
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Cancer cachexia remains an unsolved clinical problem. This syndrome is associated with muscle and adipose tissue wasting, anorexia, systemic inflammation, and major metabolic disruption. All these symptoms compromise cancer treatment outcome, quality of life, and survival. Fish oil supplementation has been found to attenuate some of the consequences of cachexia, as reported in animal models and patient trials. The potential of marine omega three fatty acids to counteract cachexia-related weight and appetite loss, and to modulate peripheral inflammation and metabolism are discussed, along the recently proposed roles in neuroinflammation. Fish oil supplementation appears as a promising strategy in adjuvant cachexia treatment. © 2016 Elsevier Inc. All rights reserved.
Palavras-chave
Appetite, Cancer cachexia, Cytokines, Fish oil, Inflammation, Wasting
Referências
  1. Argilés, J.M., Stemmler, B., López-Soriano, F.J., Busquets, S., Nonmuscle tissues contribution to cancer cachexia (2015) Mediat. Inflamm., 2015, p. 182872
  2. Babcock, T., Helton, W.S., Espat, N.J., Eicosapentaenoic acid (EPA): an antiinflammatory omega-3 fat with potential clinical applications (2000) Nutrition, 16, pp. 1116-1118
  3. Barber, M.D., McMillan, D.C., Preston, T., Ross, J.A., Fearon, K.C., Metabolic response to feeding in weight-losing pancreatic cancer patients and its modulation by a fish-oil-enriched nutritional supplement (2000) Clin. Sci. (London), 98, pp. 389-399
  4. Barber, M.D., Preston, T., McMillan, D.C., Slater, C., Ross, J.A., Fearon, K.C., Modulation of the liver export protein synthetic response to feeding by an n-3 fatty-acid-enriched nutritional supplement is associated with anabolism in cachectic cancer patients (2004) Clin. Sci. (London), 106, pp. 359-364
  5. Bauer, J., Capra, S., Battistutta, D., Davidson, W., Ash, S., Group, C.C.S., Compliance with nutrition prescription improves outcomes in patients with unresectable pancreatic cancer (2005) Clin. Nutr., 24, pp. 998-1004
  6. Bayram, I., Erbey, F., Celik, N., Nelson, J.L., Tanyeli, A., The use of a protein and energy dense eicosapentaenoic acid containing supplement for malignancy-related weight loss in children (2009) Pediatr. Blood Cancer, 52, pp. 571-574
  7. Bennani-Baiti, N., Walsh, D., What is cancer anorexia-cachexia syndrome? A historical perspective (2009) J. R. Coll. Phys. Edinburg, 39, pp. 257-262
  8. Bougnoux, P., Hajjaji, N., Ferrasson, M.N., Giraudeau, B., Couet, C., LeFloch, O., Improving outcome of chemotherapy of metastatic breast cancer by docosahexaenoic acid: a phase II trial (2009) Br. J. Cancer, 101, pp. 1978-1985
  9. Bowen, T.S., Schuler, G., Adams, V., Skeletal muscle wasting in cachexia and sarcopenia: molecular pathophysiology and impact of exercise training (2015) J. Cachexia Sarcopenia Muscle, 6, pp. 197-207
  10. Boyle, P., Ferlay, J., Cancer incidence and mortality in Europe (2005) Ann. Oncol., 16, pp. 481-488
  11. Bozzetti, F., Nutritional support of the oncology patient (2013) Crit. Rev. Oncol. Hematol., 87, pp. 172-200
  12. Bruera, E., Strasser, F., Palmer, J.L., Willey, J., Calder, K., Amyotte, G., Baracos, V., Effect of fish oil on appetite and other symptoms in patients with advanced cancer and anorexia/cachexia: a double-blind, placebo-controlled study (2003) J. Clin. Oncol., 21, pp. 129-134
  13. Burns, C.P., Halabi, S., Clamon, G., Kaplan, E., Hohl, R.J., Atkins, J.N., Schwartz, M.A., Paskett, E., Phase II study of high-dose fish oil capsules for patients with cancer- related cachexia (2004) Cancer, 101, pp. 370-378
  14. Coelho, I., Casare, F., Pequito, D.C., Borghetti, G., Yamazaki, R.K., Brito, G.A., Kryczyk, M., Fernandez, R., Fish oil supplementation reduces cachexia and tumor growth while improving renal function in tumor-bearing rats (2012) Lipids, 47, pp. 1031-1041
  15. Damsbo-Svendsen, S., Rønsholdt, M.D., Lauritzen, L., Fish oil-supplementation increases appetite in healthy adults. A randomized controlled cross-over trial (2013) Appetite, 66, pp. 62-66
  16. Del Fabbro, E., Jatoi, A., Davis, M., Fearon, K., di Tomasso, J., Vigano, A., Health professionals' attitudes toward the detection and management of cancer-related anorexia-cachexia syndrome, and a proposal for standardized assessment (2015) J. Commun. Support Oncol., 13, pp. 181-187
  17. Du, L., Yang, Y.H., Wang, Y.M., Xue, C.H., Kurihara, H., Takahashi, K., EPA-enriched phospholipids ameliorate cancer-associated cachexia mainly via inhibiting lipolysis (2015) Food Funct., 6 (12), pp. 3652-3662
  18. Fearon, K., Strasser, F., Anker, S.D., Bosaeus, I., Bruera, E., Fainsinger, R.L., Jatoi, A., Baracos, V.E., Definition and classification of cancer cachexia: an international consensus (2011) Lancet Oncol., 12, pp. 489-495
  19. Fernandez, R., Piechnik, J., Fabris, R., Malnic, G., Fernandes, L.C., Effect of chronic fish oil supplementation on renal function of normal and cachectic rats (2004) Braz. J. Med. Biol. Res., 37, pp. 1481-1489
  20. Folador, A., de Lima-Salgado, T.M., Hirabara, S.M., Aikawa, J., Yamazaki, R.K., Martins, E.F., de Oliveira, H.H., Curi, R., Effect of fish oil supplementation for two generations on changes of lymphocyte function induced by Walker 256 cancer cachexia in rats (2009) Nutr. Cancer, 61, pp. 670-679
  21. Gogos, C.A., Ginopoulos, P., Salsa, B., Apostolidou, E., Zoumbos, N.C., Kalfarentzos, F., Dietary omega-3 polyunsaturated fatty acids plus vitamin E restore immunodeficiency and prolong survival for severely ill patients with generalized malignancy: a randomized control trial (1998) Cancer, 82, pp. 395-402
  22. Gómez-Candela, C., Villarino Sanz, M., Horrisberger, A., Loria Kohen, V., Bermejo, L.M., Zamora Auñón, P., Efficacy evaluation of an oral powder supplement enriched with eicosapentaenoic acid in cancer patients (2011) Nutr. Hosp., 26, pp. 1385-1393
  23. Harvie, M., Nutritional supplements and cancer: potential benefits and proven harms (2014) Am. Soc. Clin. Oncol. Educ. Book, 2014, pp. E478-E486
  24. Hidaka, A., Shimazu, T., Sawada, N., Yamaji, T., Iwasaki, M., Sasazuki, S., Inoue, M., Tsugane, S., Fish, n-3 PUFA consumption, and pancreatic cancer risk in Japanese: a large, population-based, prospective cohort study (2015) Am. J. Clin. Nutr., 102 (6), pp. 1490-1497. , Japan Public Health Center-based Prospective Study Group
  25. Iagher, F., de Brito Belo, S.R., Souza, W.M., Nunes, J.R., Naliwaiko, K., Sassaki, G.L., Bonatto, S.J., Fernandes, L.C., Antitumor and anti-cachectic effects of shark liver oil and fish oil: comparison between independent or associative chronic supplementation in Walker 256 tumor-bearing rats (2013) Lipids Health Dis., 12, p. 146
  26. Jatoi, A., Rowland, K., Loprinzi, C.L., Sloan, J.A., Dakhil, S.R., MacDonald, N., Gagnon, B., Christensen, B., An eicosapentaenoic acid supplement versus megestrol acetate versus both for patients with cancer-associated wasting: a North Central Cancer Treatment Group and National Cancer Institute of Canada collaborative effort (2004) J. Clin. Oncol., 22, pp. 2469-2476
  27. Klein, G.L., Petschow, B.W., Shaw, A.L., Weaver, E., Gut barrier dysfunction and microbial translocation in cancer cachexia: a new therapeutic target (2013) Curr. Opin. Support Palliat. Care, 7, pp. 361-367
  28. Kumar, N.B., Kazi, A., Smith, T., Crocker, T., Yu, D., Reich, R.R., Reddy, K., Bepler, G., Cancer cachexia: traditional therapies and novel molecular mechanism-based approaches to treatment (2010) Curr. Treat Options Oncol., 11, pp. 107-117
  29. Mantovani, G., Macciò, A., Madeddu, C., Gramignano, G., Lusso, M.R., Serpe, R., Massa, E., Deiana, L., A phase II study with antioxidants, both in the diet and supplemented, pharmaconutritional support, progestagen, and anti-cyclooxygenase-2 showing efficacy and safety in patients with cancer-related anorexia/cachexia and oxidative stress (2006) Cancer Epidemiol. Biomarkers Prev., 15, pp. 1030-1034
  30. Mantovani, G., Macciò, A., Madeddu, C., Serpe, R., Massa, E., Dessì, M., Panzone, F., Contu, P., Randomized phase III clinical trial of five different arms of treatment in 332 patients with cancer cachexia (2010) Oncologist, 15, pp. 200-211
  31. Mantovani, G., Madeddu, C., (2006) Epidemiology of Cachexia, pp. 39-43. , Cachexia and Wasting: A Modern Approach Springer, Cagliari, Italy, G. Mantovani (Ed.)
  32. Mauri, D., Tsiara, A., Valachis, A., Kalopita, K., Tsali, L., Tolis, P., Polyzos, N.P., Cancer cachexia: global awareness and guideline implementation on the web (2013) BMJ Support Palliat. Care, 3, pp. 155-160
  33. Meriggi, F., Cancer cachexia: one step ahead (2015) Rev. Recent Clin. Trials, 10, pp. 246-250
  34. Miyata, H., Yano, M., Yasuda, T., Hamano, R., Yamasaki, M., Hou, E., Motoori, M., Doki, Y., Randomized study of clinical effect of enteral nutrition support during neoadjuvant chemotherapy on chemotherapy-related toxicity in patients with esophageal cancer (2012) Clin Nutr., 31, pp. 330-336
  35. Molfino, A., Gioia, G., Rossi Fanelli, F., Laviano, A., Contribution of neuroinflammation to the pathogenesis of cancer cachexia (2015) Mediat. Inflamm., 2015, p. 801685
  36. Morley, J.E., Calories and cachexia (2009) Curr. Opin. Clin. Nutr. Metab. Care, 12, pp. 607-610
  37. Murphy, R.A., Mourtzakis, M., Mazurak, V.C., N-3 polyunsaturated fatty acids: the potential role for supplementation in cancer (2012) Curr. Opin. Clin. Nutr. Metab Care, 15, pp. 246-251
  38. Murphy, R.A., Yeung, E., Mazurak, V.C., Mourtzakis, M., Influence of eicosapentaenoic acid supplementation on lean body mass in cancer cachexia (2011) Br. J. Cancer, 105, pp. 1469-1473
  39. Muscaritoli, M., Bossola, M., Aversa, Z., Bellantone, R., Rossi Fanelli, F., Prevention and treatment of cancer cachexia: new insights into an old problem (2006) Eur. J. Cancer, 42, pp. 31-41
  40. Muscaritoli, M., Molfino, A., Lucia, S., Rossi Fanelli, F., Cachexia: a preventable comorbidity of cancer. A T.A.R.G.E.T. approach (2015) Crit. Rev. Oncol. Hematol., 94, pp. 251-259
  41. Nabavi, S.F., Bilotto, S., Russo, G.L., Orhan, I.E., Habtemariam, S., Daglia, M., Devi, K.P., Nabavi, S.M., Omega-3 polyunsaturated fatty acids and cancer: lessons learned from clinical trials (2015) Cancer Metastasis Rev., 34, pp. 359-380
  42. Ogilvie, G.K., Fettman, M.J., Mallinckrodt, C.H., Walton, J.A., Hansen, R.A., Davenport, D.J., Gross, K.L., Hand, M.S., Effect of fish oil, arginine, and doxorubicin chemotherapy on remission and survival time for dogs with lymphoma: a double- blind, randomized placebo-controlled study (2000) Cancer, 88, pp. 1916-1928
  43. Persson, C., Glimelius, B., Rönnelid, J., Nygren, P., Impact of fish oil and melatonin on cachexia in patients with advanced gastrointestinal cancer: a randomized pilot study (2005) Nutrition, 21, pp. 170-178
  44. Pham, N.M., Mizoue, T., Tanaka, K., Tsuji, I., Tamakoshi, A., Matsuo, K., Ito, H., Tsugane, S., Physical activity and colorectal cancer risk: an evaluation based on a systematic review of epidemiologic evidence among the Japanese population (2012) Jpn. J. Clin. Oncol., 42, pp. 2-13. , Japan, R.G.f.t.D.a.E.o.C.P.S.i
  45. Pinto, J.A., Folador, A., Bonato, S.J., Aikawa, J., Yamazaki, R.K., Pizato, N., Facin, M., Fernandes, L.C., Fish oil supplementation in F1 generation associated with naproxen, clenbuterol, and insulin administration reduce tumor growth and cachexia in Walker 256 tumor-bearing rats (2004) J. Nutr. Biochem., 15, pp. 358-365
  46. Sawada, N., Inoue, M., Iwasaki, M., Sasazuki, S., Shimazu, T., Yamaji, T., Takachi, R., Tsugane, S., Consumption of n-3 fatty acids and fish reduces risk of hepatocellular carcinoma (2012) Gastroenterology, 142, pp. 1468-1475. , Group, J.P.H.C.-B.P.S
  47. Schiessel, D.L., Yamazaki, R.K., Kryczyk, M., Coelho, I., Yamaguchi, A.A., Pequito, D.C., Brito, G.A., Fernandes, L.C., α-Linolenic Fatty Acid Supplementation Decreases Tumor Growth and Cachexia Parameters in Walker 256 Tumor-Bearing Rats (2015) Nutr. Cancer, 67, pp. 839-846
  48. Smith, H.J., Greenberg, N.A., Tisdale, M.J., Effect of eicosapentaenoic acid, protein and amino acids on protein synthesis and degradation in skeletal muscle of cachectic mice (2004) Br. J. Cancer, 91, pp. 408-412
  49. Taylor, L.A., Pletschen, L., Arends, J., Unger, C., Massing, U., Marine phospholipids--a promising new dietary approach to tumor-associated weight loss (2010) Support Care Cancer, 18, pp. 159-170
  50. Tisdale, M.J., Inhibition of lipolysis and muscle protein degradation by EPA in cancer cachexia (1996) Nutrition, 12, pp. S31-S33
  51. van der Meij, B.S., Langius, J.A., Spreeuwenberg, M.D., Slootmaker, S.M., Paul, M.A., Smit, E.F., van Leeuwen, P.A., Oral nutritional supplements containing n-3 polyunsaturated fatty acids affect quality of life and functional status in lung cancer patients during multimodality treatment: an RCT (2012) Eur. J. Clin. Nutr., 66, pp. 399-404
  52. van Norren, K., Kegler, D., Argilés, J.M., Luiking, Y., Gorselink, M., Laviano, A., Arts, K., van Helvoort, A., Dietary supplementation with a specific combination of high protein, leucine, and fish oil improves muscle function and daily activity in tumour-bearing cachectic mice (2009) Br. J. Cancer, 100, pp. 713-722
  53. von Haehling, S., Anker, S.D., Prevalence, incidence and clinical impact of cachexia: facts and numbers-update 2014 (2014) J. Cachexia Sarcopenia Muscle, 5, pp. 261-263
  54. Wang, H., Li, T.L., Hsia, S., Su, I.L., Chan, Y.L., Wu, C.J., Skeletal muscle atrophy is attenuated in tumor-bearing mice under chemotherapy by treatment with fish oil and selenium (2015) Oncotarget, 6, pp. 7758-7773
  55. Weed, H.G., Ferguson, M.L., Gaff, R.L., Hustead, D.S., Nelson, J.L., Voss, A.C., Lean body mass gain in patients with head and neck squamous cell cancer treated perioperatively with a protein- and energy-dense nutritional supplement containing eicosapentaenoic acid (2011) Head Neck, 33, pp. 1027-1033
  56. Wigmore, S.J., Fearon, K.C., Maingay, J.P., Ross, J.A., Down-regulation of the acute-phase response in patients with pancreatic cancer cachexia receiving oral eicosapentaenoic acid is mediated via suppression of interleukin-6 (1997) Clin. Sci. (London), 92, pp. 215-221
  57. Wigmore, S.J., Ross, J.A., Falconer, J.S., Plester, C.E., Tisdale, M.J., Carter, D.C., Fearon, K.C., The effect of polyunsaturated fatty acids on the progress of cachexia in patients with pancreatic cancer (1996) Nutrition, 12, pp. S27-S30
  58. Yeh, K.Y., Wang, H.M., Chang, J.W., Huang, J.S., Lai, C.H., Lan, Y.J., Wu, T.H., Wang, C.H., Omega-3 fatty acid-, micronutrient-, and probiotic-enriched nutrition helps body weight stabilization in head and neck cancer cachexia (2013) Oral Surg. Oral Med. Oral Pathol. Oral Radiol., 116, pp. 41-48