Influence on voxel-based dosimetry: noise effect on absorbed dose dosimetry at single time-point versus sequential single-photon emission computed tomography

dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorFONDA, Uysha de S.
dc.contributor.authorLEITAO, Andre L. A.
dc.contributor.authorPAIVA, Marcia M. D. P.
dc.contributor.authorWILLEGAIGNON, Jose
dc.contributor.authorJOSEFSSON, Anders
dc.contributor.authorBUCHPIGUEL, Carlos A.
dc.contributor.authorSAPIENZA, Marcelo T.
dc.date.accessioned2023-08-16T17:46:35Z
dc.date.available2023-08-16T17:46:35Z
dc.date.issued2023
dc.description.abstractObjectiveThe purpose of this study was to evaluate how statistical fluctuation in single-photon emission computed tomography (SPECT) images propagate to absorbed dose maps. MethodsSPECT/computed tomography (CT) images of iodine-131 filled phantoms, using different acquisition and processing protocols, were evaluated using STRATOS software to assess the absorbed dose distribution at the voxel level. Absorbed dose values and coefficient of variation (COV) were analyzed for dosimetry based on single time-point SPECT images and time-integrated activities of SPECT sequences with low and high counts. ResultsConsidering dosimetry based on a single time-point, the mean absorbed dose was not significantly affected by total counts or reconstruction parameters, but the uniformity of the absorbed dose maps had an almost linear correlation with SPECT noise. When high- and low-count SPECT sequences were used to generate an absorbed dose map, the absorbed dose COV for each of the temporal sequences was slightly lower than the absorbed dose COV based on the single SPECT image with the highest count included in the sequence. ConclusionThe impact of changes in SPECT counts and reconstruction parameters is almost linear when dosimetry is based on isolated SPECT images, but less pronounced when dosimetry is based on sequential SPECTs.eng
dc.description.indexMEDLINE
dc.description.indexPubMed
dc.description.indexWoS
dc.description.indexScopus
dc.identifier.citationNUCLEAR MEDICINE COMMUNICATIONS, v.44, n.7, p.596-603, 2023
dc.identifier.doi10.1097/MNM.0000000000001697
dc.identifier.eissn1473-5628
dc.identifier.issn0143-3636
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/54647
dc.language.isoeng
dc.publisherLIPPINCOTT WILLIAMS & WILKINSeng
dc.relation.ispartofNuclear Medicine Communications
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright LIPPINCOTT WILLIAMS & WILKINSeng
dc.subjectin-vivo dosimetryeng
dc.subjectmolecular imagingeng
dc.subjectnuclear medicineeng
dc.subjectsingle-photon emission computed tomographyeng
dc.subject.other3-dimensional dosimetryeng
dc.subject.otherquantitative specteng
dc.subject.otherdistributionseng
dc.subject.othersoftwareeng
dc.subject.otherqualityeng
dc.subject.wosRadiology, Nuclear Medicine & Medical Imagingeng
dc.titleInfluence on voxel-based dosimetry: noise effect on absorbed dose dosimetry at single time-point versus sequential single-photon emission computed tomographyeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryisous
hcfmusp.author.externalLEITAO, Andre L. A.:Nucleos Radiol & Med Nucl, Brasilia, Brazil
hcfmusp.author.externalJOSEFSSON, Anders:Univ Pittsburgh, Dept Radiol, Pittsburgh, PA USA
hcfmusp.citation.scopus0
hcfmusp.contributor.author-fmusphcUYSHA DE SOUZA FONDA
hcfmusp.contributor.author-fmusphcMARCIA MARIA DINIZ PONTES PAIVA
hcfmusp.contributor.author-fmusphcJOSE WILLEGAIGNON DE AMORIM DE CARVALHO
hcfmusp.contributor.author-fmusphcCARLOS ALBERTO BUCHPIGUEL
hcfmusp.contributor.author-fmusphcMARCELO TATIT SAPIENZA
hcfmusp.description.beginpage596
hcfmusp.description.endpage603
hcfmusp.description.issue7
hcfmusp.description.volume44
hcfmusp.origemWOS
hcfmusp.origem.pubmed37068008
hcfmusp.origem.scopus2-s2.0-85163239777
hcfmusp.origem.wosWOS:001004241800004
hcfmusp.publisher.cityPHILADELPHIAeng
hcfmusp.publisher.countryUSAeng
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