Role of Genetic Polymorphisms in the Development and Prognosis of Sporadic and Familial Prostate Cancer

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorREIS, Sabrina T.
dc.contributor.authorVIANA, Nayara I.
dc.contributor.authorLEITE, Katia R. M.
dc.contributor.authorDIOGENES, Erico
dc.contributor.authorANTUNES, Alberto A.
dc.contributor.authorISCAIFE, Alexandre
dc.contributor.authorNESRALLAH, Adriano J.
dc.contributor.authorPASSEROTTI, Carlo C.
dc.contributor.authorSROUGI, Victor
dc.contributor.authorPONTES-JUNIOR, Jose
dc.contributor.authorSALLES, Mary Ellen
dc.contributor.authorNAHAS, William C.
dc.contributor.authorSROUGI, Miguel
dc.date.accessioned2017-02-16T12:39:43Z
dc.date.available2017-02-16T12:39:43Z
dc.date.issued2016
dc.description.abstractBackgrounds Our aim was to evaluate the role of 20 genetic polymorphisms in the development and prognosis of sporadic and familial PC. A case-control study of 185 patients who underwent radical prostatectomy from 1997 to 2011. These patients were divided into two groups based on their family history. Gleason grade, PSA value and pathological TNM 2002 stage were used as prognostic factors. Blood samples from 70 men without PC were used as controls. The SNPs were genotyped using a TaqMan SNP Genotyping Assay Kit. Results Considering susceptibility, the polymorphic allele in the SNP rs2660753 on chromosome 3 was significantly more prevalent in controls (p = 0.01). For familial clustering, the polymorphic homozygote genotype of the SNP rs7931342 was five times more frequent in patients with familial PC compared to sporadic PC (p = 0.01). Regarding the SNP 1447295, the polymorphic homozygote genotype was more prevalent in patients with organ-confined PC (p = 0.05), and most importantly, the polymorphic allele occurred more frequently in patients without biochemical recurrence (p = 0.01). Kaplan-Meier analysis showed a median biochemical recurrence free survival of 124.2 compared to 85.6 months for patients with the wild-type allele (p = 0.007). Conclusion Our findings provide the evidence for the association of 20 recently highlighted SNPs and their susceptibility, familial clustering, staging, Gleason score and biochemical recurrence of PC. We believe that the association between these SNPs and PC may contribute to the development of alternative tools that can facilitate the early detection and prognosis of this disease.
dc.description.indexMEDLINE
dc.description.sponsorshipFAPESP (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo) [2012/19258-5]
dc.identifier.citationPLOS ONE, v.11, n.12, article ID e0166380, 13p, 2016
dc.identifier.doi10.1371/journal.pone.0166380
dc.identifier.issn1932-6203
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/17792
dc.language.isoeng
dc.publisherPUBLIC LIBRARY SCIENCE
dc.relation.ispartofPlos One
dc.rightsopenAccess
dc.rights.holderCopyright PUBLIC LIBRARY SCIENCE
dc.subject.othergenome-wide
dc.subject.othersusceptibility
dc.subject.otherassociation
dc.subject.othermultiple
dc.subject.otherloci
dc.subject.otherrisk
dc.subject.otherstatistics
dc.subject.otherconsortium
dc.subject.othervariants
dc.subject.wosMultidisciplinary Sciences
dc.titleRole of Genetic Polymorphisms in the Development and Prognosis of Sporadic and Familial Prostate Cancer
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalSALLES, Mary Ellen:Univ Sao Paulo, Sch Med, Dept Urol, Lab Med Invest LIM55, Sao Paulo, Brazil
hcfmusp.citation.scopus5
hcfmusp.contributor.author-fmusphcSABRINA THALITA DOS REIS FARIA
hcfmusp.contributor.author-fmusphcNAYARA IZABEL VIANA MOURA
hcfmusp.contributor.author-fmusphcKATIA RAMOS MOREIRA LEITE
hcfmusp.contributor.author-fmusphcERICO LUIS DANTAS DIOGENES SALDANHA
hcfmusp.contributor.author-fmusphcALBERTO AZOUBEL ANTUNES
hcfmusp.contributor.author-fmusphcALEXANDRE ISCAIFE
hcfmusp.contributor.author-fmusphcADRIANO JOAO NESRALLAH
hcfmusp.contributor.author-fmusphcCARLO CAMARGO PASSEROTTI
hcfmusp.contributor.author-fmusphcVICTOR SROUGI
hcfmusp.contributor.author-fmusphcJOSE PONTES JUNIOR
hcfmusp.contributor.author-fmusphcWILLIAM CARLOS NAHAS
hcfmusp.contributor.author-fmusphcMIGUEL SROUGI
hcfmusp.description.articlenumbere0166380
hcfmusp.description.issue12
hcfmusp.description.volume11
hcfmusp.origemWOS
hcfmusp.origem.pubmed27906997
hcfmusp.origem.scopus2-s2.0-84999810308
hcfmusp.origem.wosWOS:000389482700024
hcfmusp.publisher.citySAN FRANCISCO
hcfmusp.publisher.countryUSA
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