A prospective, open, comparative study of 5% potassium hydroxide solution versus cryotherapy in the treatment of genital warts in men

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorCAMARGO, Caio Lamunier de Abreu
dc.contributor.authorBELDA JUNIOR, Walter
dc.contributor.authorFAGUNDES, Luiz Jorge
dc.contributor.authorROMITI, Ricardo
dc.date.accessioned2014-07-03T20:33:31Z
dc.date.available2014-07-03T20:33:31Z
dc.date.issued2014
dc.description.abstractBACKGROUND: Genital warts are caused by human papillomavirus infection and represent one of the most common sexually transmitted diseases. Many infections are transient but the virus may recur, persist, or become latent. To date, there is no effective antiviral treatment to eliminate HPV infection and most therapies are aimed at the destruction of visible lesions. Potassium hydroxide is a strong alkali that has been shown to be safe and effective for the treatment of genital warts and molluscum contagiosum. Cryotherapy is considered one of the most established treatments for genital warts. No comparative trials have been reported to date on the use of potassium hydroxide for genital warts. OBJECTIVE: A prospective, open-label, randomized clinical trial was conducted to compare topical potassium hydroxide versus cryotherapy in the treatment of genital warts affecting immunocompetent, sexually active men. METHODS: Over a period of 10 months, 48 patients were enrolled. They were randomly divided into two groups and selected on an alternative basis for either potassium hydroxide therapy or cryotherapy. While response to therapy did not differ substantially between both treatment modalities, side effects such as local pain and post-treatment hypopigmentation were considerably more prevalent in the groups treated using cryotherapy. Result: In our study, potassium hydroxide therapy proved to be at least as effective as cryotherapy and offered the benefit of a better safety profile. CONCLUSION: Topical 5% potassium hydroxide presents an effective, safe, and low-cost treatment modality for genital warts in men and should be included in the spectrum of therapies for genital warts.
dc.description.indexSciELO
dc.identifier.citationANAIS BRASILEIROS DE DERMATOLOGIA, v.89, n.2, p.236-240, 2014
dc.identifier.doi10.1590/abd1806-4841.20141702
dc.identifier.eissn1806-4841
dc.identifier.issn0365-0596
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/5639
dc.language.isoeng
dc.publisherSociedade Brasileira de Dermatologia
dc.relation.ispartofAnais Brasileiros de Dermatologia
dc.rightsopenAccess
dc.rights.holderCopyright Sociedade Brasileira de Dermatologia
dc.subjectClinical protocols
dc.subjectComparative study
dc.subjectCondylomata acuminata
dc.subjectCryotherapy
dc.subjectGenital diseases, male
dc.subjectIntention to treat analysis
dc.subjectMale urogenital diseases
dc.subject.otherMOLLUSCUM CONTAGIOSUM
dc.subject.otherCONDYLOMATA ACUMINATA
dc.subject.otherPAPILLOMAVIRUS
dc.subject.otherPODOPHYLLIN
dc.subject.otherCRYOSURGERY
dc.subject.otherSTRATEGIES
dc.subject.otherTRIAL
dc.subject.otherCREAM
dc.subject.wosDermatology
dc.titleA prospective, open, comparative study of 5% potassium hydroxide solution versus cryotherapy in the treatment of genital warts in men
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalFAGUNDES, Luiz Jorge:São Paulo University, São Paulo, Brazil
hcfmusp.citation.scopus17
hcfmusp.contributor.author-fmusphcCAIO LAMUNIER DE ABREU CAMARGO
hcfmusp.contributor.author-fmusphcWALTER BELDA JUNIOR
hcfmusp.contributor.author-fmusphcRICARDO ROMITI
hcfmusp.description.beginpage236
hcfmusp.description.endpage240
hcfmusp.description.issue2
hcfmusp.description.volume89
hcfmusp.origemWOS
hcfmusp.origem.pubmed24770498
hcfmusp.origem.scieloSCIELO:S0365-05962014000200236
hcfmusp.origem.scopus2-s2.0-84899417059
hcfmusp.origem.wosWOS:000335171600004
hcfmusp.publisher.cityRIO DE JANEIRO
hcfmusp.publisher.countryBRAZIL
hcfmusp.relation.referenceCates W, 1999, SEX TRANSM DIS, V26, pS2, DOI 10.1097/00007435-199904001-00002
hcfmusp.scopus.lastupdate2024-06-09
relation.isAuthorOfPublicationf35a8893-0e84-4647-915b-a352596de65f
relation.isAuthorOfPublicatione9850765-f508-4f80-9a7d-41636a93a70f
relation.isAuthorOfPublication830df912-b6d8-4dec-96d9-77c7eb49d3ee
relation.isAuthorOfPublication.latestForDiscoveryf35a8893-0e84-4647-915b-a352596de65f
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