Beta-alanine (Carnosyn (TM)) supplementation in elderly subjects (60-80 years): effects on muscle carnosine content and physical capacity

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorFAVERO, Serena del
dc.contributor.authorROSCHEL, Hamilton
dc.contributor.authorSOLIS, Marina Y.
dc.contributor.authorHAYASHI, Ana P.
dc.contributor.authorARTIOLI, Guilherme G.
dc.contributor.authorOTADUY, Maria Concepcion
dc.contributor.authorBENATTI, Fabiana B.
dc.contributor.authorHARRIS, Roger C.
dc.contributor.authorWISE, John A.
dc.contributor.authorLEITE, Claudia C.
dc.contributor.authorPEREIRA, Rosa M.
dc.contributor.authorSA-PINTO, Ana L. de
dc.contributor.authorLANCHA-JUNIOR, Antonio Herbert
dc.contributor.authorGUALANO, Bruno
dc.date.accessioned2013-07-30T14:42:03Z
dc.date.available2013-07-30T14:42:03Z
dc.date.issued2012
dc.description.abstractThe aim of this study was to investigate the effects of beta-alanine supplementation on exercise capacity and the muscle carnosine content in elderly subjects. Eighteen healthy elderly subjects (60-80 years, 10 female and 4 male) were randomly assigned to receive either beta-alanine (BA, n = 12) or placebo (PL, n = 6) for 12 weeks. The BA group received 3.2 g of beta-alanine per day (2 x 800 mg sustained-release Carnosyn (TM) tablets, given 2 times per day). The PL group received 2 x (2 x 800 mg) of a matched placebo. At baseline (PRE) and after 12 weeks (POST-12) of supplementation, assessments were made of the muscle carnosine content, anaerobic exercise capacity, muscle function, quality of life, physical activity and food intake. A significant increase in the muscle carnosine content of the gastrocnemius muscle was shown in the BA group (+85.4%) when compared with the PL group (+7.2%) (p = 0.004; ES: 1.21). The time-to-exhaustion in the constant-load submaximal test (i.e., TLIM) was significantly improved (p = 0.05; ES: 1.71) in the BA group (+36.5%) versus the PL group (+8.6%). Similarly, time-to-exhaustion in the incremental test was also significantly increased (p = 0.04; ES 1.03) following beta-alanine supplementation (+12.2%) when compared with placebo (+0.1%). Significant positive correlations were also shown between the relative change in the muscle carnosine content and the relative change in the time-to-exhaustion in the TLIM test (r = 0.62; p = 0.01) and in the incremental test (r = 0.48; p = 0.02). In summary, the current data indicate for the first time, that beta-alanine supplementation is effective in increasing the muscle carnosine content in healthy elderly subjects, with subsequent improvement in their exercise capacity.
dc.description.indexMEDLINE
dc.description.sponsorshipNatural Alternatives International (NAI)
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2010/11221-0]
dc.description.sponsorshipUK national funding bodies
dc.description.sponsorshipNAI at the Korea National Sport University
dc.identifier.citationAMINO ACIDS, v.43, n.1, p.49-56, 2012
dc.identifier.doi10.1007/s00726-011-1190-x
dc.identifier.issn0939-4451
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/537
dc.language.isoeng
dc.publisherSPRINGER
dc.relation.ispartofAmino Acids
dc.rightsrestrictedAccess
dc.rights.holderCopyright SPRINGER
dc.subjectAcidosis
dc.subjectBuffering capacity
dc.subjectErgogenic aid
dc.subjectElderly people
dc.subject.otherhuman vastus lateralis
dc.subject.othertaurine contents
dc.subject.otherfiber type
dc.subject.othersarcopenia
dc.subject.otherexercise
dc.subject.othermen
dc.subject.otherhypertrophy
dc.subject.otherperformance
dc.subject.otherstrength
dc.subject.wosBiochemistry & Molecular Biology
dc.titleBeta-alanine (Carnosyn (TM)) supplementation in elderly subjects (60-80 years): effects on muscle carnosine content and physical capacity
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.affiliation.countryInglaterra
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryisogb
hcfmusp.affiliation.countryisous
hcfmusp.author.externalFAVERO, Serena del:Univ Sao Paulo, Sch Phys Educ & Sport, BR-05508030 Sao Paulo, Brazil
hcfmusp.author.externalROSCHEL, Hamilton:Univ Sao Paulo, Sch Phys Educ & Sport, BR-05508030 Sao Paulo, Brazil
hcfmusp.author.externalSOLIS, Marina Y.:Univ Sao Paulo, Sch Phys Educ & Sport, BR-05508030 Sao Paulo, Brazil
hcfmusp.author.externalHAYASHI, Ana P.:Univ Sao Paulo, Sch Phys Educ & Sport, BR-05508030 Sao Paulo, Brazil
hcfmusp.author.externalARTIOLI, Guilherme G.:Univ Sao Paulo, Sch Phys Educ & Sport, BR-05508030 Sao Paulo, Brazil
hcfmusp.author.externalBENATTI, Fabiana B.:Univ Sao Paulo, Sch Phys Educ & Sport, BR-05508030 Sao Paulo, Brazil
hcfmusp.author.externalHARRIS, Roger C.:Junipa Ltd, Newmarket, Suffolk, England
hcfmusp.author.externalWISE, John A.:Nat Alternat Int Inc, San Marcos, TX USA
hcfmusp.author.externalLANCHA-JUNIOR, Antonio Herbert:Univ Sao Paulo, Sch Phys Educ & Sport, BR-05508030 Sao Paulo, Brazil
hcfmusp.author.externalGUALANO, Bruno:Univ Sao Paulo, Sch Phys Educ & Sport, BR-05508030 Sao Paulo, Brazil
hcfmusp.citation.scopus101
hcfmusp.contributor.author-fmusphcMARIA CONCEPCION GARCIA OTADUY
hcfmusp.contributor.author-fmusphcCLAUDIA DA COSTA LEITE
hcfmusp.contributor.author-fmusphcROSA MARIA RODRIGUES PEREIRA
hcfmusp.contributor.author-fmusphcANA LUCIA DE SA PINTO
hcfmusp.description.beginpage49
hcfmusp.description.endpage56
hcfmusp.description.issue1
hcfmusp.description.volume43
hcfmusp.lim.ref2012
hcfmusp.origemWOS
hcfmusp.origem.pubmed22143432
hcfmusp.origem.scopus2-s2.0-84862765959
hcfmusp.origem.wosWOS:000305210800007
hcfmusp.publisher.cityNEW YORK
hcfmusp.publisher.countryUSA
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hcfmusp.scopus.lastupdate2024-05-17
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