Air pollution influence on serum inflammatory interleukins: A prospective study in childhood-onset systemic lupus erythematous patients

Página do item simplificado
dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorFARHAT, Sylvia Costa Lima
dc.contributor.authorEJNISMAN, Carolina
dc.contributor.authorALVES, Andressa Guariento Ferreira
dc.contributor.authorGOULART, Maria Fernanda Giacomin
dc.contributor.authorLICHTENFELS, Ana Julia de Faria Coimbra
dc.contributor.authorBRAGA, Alfesio Luis Ferreira
dc.contributor.authorPEREIRA, Luiz Alberto Amador
dc.contributor.authorELIAS, Adriana Maluf
dc.contributor.authorSILVA, Clovis A.
dc.date.accessioned2022-02-24T17:18:09Z
dc.date.available2022-02-24T17:18:09Z
dc.date.issued2021
dc.description.abstractObjective To assess the effect of individual exposure, in real-time, to traffic-related pollutants on serum interleukin levels of childhood-onset lupus erythematous systemic (c-SLE) patients. Methods A longitudinal and observational design was conducted in 12 repeated measures of serum samples and clinical evaluations (totaling 108 measurements) of c-SLE patients over 30 consecutive months. Real-time, individual exposure to fine particles (PM2.5) and nitrogen dioxide (NO2) was measured with portable monitors. Generalized estimating equation was used to evaluate the association between exposure to PM2.5 and NO2 and the following serum cytokine levels on the 7 days preceding clinical assessment and serum collection: MCP1, IL-6, IL-8, IL-10, IL-17, IFN-alpha, and TNF-alpha. Disease activity and other risk factors were also controlled. Results An interquartile range (IQR) increase in PM2.5 daily concentration was significantly associated with increased levels of TNF-alpha on the third, fourth, and seventh day after exposure; IL-10 on the third and fourth day after exposure; IL-17 on the third and seventh day after exposure; and INF-alpha on the third day after exposure (p < 0.05). An IQR increase in 7-day moving average of PM2.5 was associated with a 6.2 pg/mL (95% CI: 0.5; 11.8; p = 0.04) increase in serum IFN-alpha level. An unexpected significant association was observed between an IQR increase in NO(2)7-day cumulative concentration and a decrease of 1.6 pg/mL (95% CI: -2.6; -0.7; p < 0.001) in serum IL-17. Conclusion Real-time exposure to PM2.5 prospectively associated with increased serum TNF-alpha, INF-alpha, IL-10, and IL-17 levels in c-SLE patients.eng
dc.description.indexMEDLINEeng
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2015/03756-4, 13/21508-2]
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ)Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ) [302724/2011-7, 472155/2012-1, 304984/2020-5]
dc.description.sponsorshipFederico Foundation
dc.identifier.citationLUPUS, v.30, n.14, p.2268-2275, 2021
dc.identifier.doi10.1177/09612033211061479
dc.identifier.eissn1477-0962
dc.identifier.issn0961-2033
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/44521
dc.language.isoeng
dc.publisherSAGE PUBLICATIONS LTDeng
dc.relation.ispartofLupus
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright SAGE PUBLICATIONS LTDeng
dc.subjectChildhood-systemic lupus erythematosuseng
dc.subjectair pollutioneng
dc.subjectreal-time exposureeng
dc.subjectserum cytokineseng
dc.subjectinhalable fine particleseng
dc.subjecttraffic-related-pollutioneng
dc.subject.otherjuvenile idiopathic arthritiseng
dc.subject.otherautoimmune rheumatic-diseaseeng
dc.subject.otheroxidative stresseng
dc.subject.otherrisk-factorseng
dc.subject.otherexposureeng
dc.subject.othercellseng
dc.subject.otherhyperactivityeng
dc.subject.otherpollutantseng
dc.subject.otherexhausteng
dc.subject.otherinduceeng
dc.subject.wosRheumatologyeng
dc.titleAir pollution influence on serum inflammatory interleukins: A prospective study in childhood-onset systemic lupus erythematous patientseng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalEJNISMAN, Carolina:Univ Sao Paulo, Fac Med, Environm Epidemiol Study Grp, Lab Expt Air Pollut, Sao Paulo, Brazil; Univ Santo Amaro, Sao Paulo, Brazil
hcfmusp.author.externalALVES, Andressa Guariento Ferreira:Univ Sao Paulo, Fac Med, Environm Epidemiol Study Grp, Lab Expt Air Pollut, Sao Paulo, Brazil
hcfmusp.citation.scopus2
hcfmusp.contributor.author-fmusphcSYLVIA COSTA LIMA FARHAT
hcfmusp.contributor.author-fmusphcMARIA FERNANDA GIACOMIN GOULART
hcfmusp.contributor.author-fmusphcANA JULIA DE FARIA COIMBRA LICHTENFELS
hcfmusp.contributor.author-fmusphcALFESIO LUIS FERREIRA BRAGA
hcfmusp.contributor.author-fmusphcLUIZ ALBERTO AMADOR PEREIRA
hcfmusp.contributor.author-fmusphcADRIANA MALUF ELIAS SALLUM
hcfmusp.contributor.author-fmusphcCLOVIS ARTUR ALMEIDA DA SILVA
hcfmusp.description.articlenumber9612033211061470
hcfmusp.description.beginpage2268
hcfmusp.description.endpage2275
hcfmusp.description.issue14
hcfmusp.description.volume30
hcfmusp.origemWOS
hcfmusp.origem.pubmed34879788
hcfmusp.origem.scopus2-s2.0-85121379509
hcfmusp.origem.wosWOS:000729547900001
hcfmusp.publisher.cityLONDONeng
hcfmusp.publisher.countryENGLANDeng
hcfmusp.relation.referenceBernatsky S, 2016, ENVIRON RES, V146, P85, DOI 10.1016/j.envres.2015.12.021eng
hcfmusp.relation.referenceBernatsky S, 2015, ENVIRON RES, V140, P474, DOI 10.1016/j.envres.2015.05.007eng
hcfmusp.relation.referenceCalderon-Garciduenas L, 2013, ARH HIG RADA TOKSIKO, V64, P23, DOI 10.2478/10004-1254-64-2013-2219eng
hcfmusp.relation.referenceCalderon-Garciduenas L, 2009, TOXICOL PATHOL, V37, P161, DOI 10.1177/0192623308329340eng
hcfmusp.relation.referenceCastaneda AR, 2018, TOXICOL LETT, V292, P85, DOI 10.1016/j.toxlet.2018.04.020eng
hcfmusp.relation.referenceChu X, 2016, ENVIRON TOXICOL PHAR, V48, P76, DOI 10.1016/j.etap.2016.10.006eng
hcfmusp.relation.referenceConde PG, 2018, MOD RHEUMATOL, V28, P156, DOI 10.1080/14397595.2017.1332508eng
hcfmusp.relation.referenceCrow MK, 2014, J IMMUNOL, V192, P5459, DOI 10.4049/jimmunol.1002795eng
hcfmusp.relation.referenceDobreva ZG, 2015, TOXICOL IND HEALTH, V31, P1210, DOI 10.1177/0748233713491812eng
hcfmusp.relation.referenceDurga M, 2014, ENVIRON TOXICOL PHAR, V38, P518, DOI 10.1016/j.etap.2014.08.003eng
hcfmusp.relation.referenceFernandes EC, 2015, ARTHRIT CARE RES, V67, P1609, DOI 10.1002/acr.22603eng
hcfmusp.relation.referenceAlves AGF, 2018, CLIN RHEUMATOL, V37, P683, DOI 10.1007/s10067-017-3893-1eng
hcfmusp.relation.referenceFiorito G, 2018, ENVIRON MOL MUTAGEN, V59, P234, DOI 10.1002/em.22153eng
hcfmusp.relation.referenceGoulart MFG, 2020, PEDIATR NEPHROL, V35, P1247, DOI 10.1007/s00467-020-04517-3eng
hcfmusp.relation.referenceGladman DD, 2002, J RHEUMATOL, V29, P288eng
hcfmusp.relation.referenceGomes RC, 2016, ARTHRIT CARE RES, V68, P1736, DOI 10.1002/acr.22881eng
hcfmusp.relation.referenceGorr MW, 2015, AM J PHYSIOL-HEART C, V309, pH53, DOI 10.1152/ajpheart.00162.2015eng
hcfmusp.relation.referenceGruzieva O, 2017, ENVIRON HEALTH PERSP, V125, DOI 10.1289/EHP460eng
hcfmusp.relation.referenceGu XY, 2017, ENVIRON POLLUT, V226, P163, DOI 10.1016/j.envpol.2017.03.070eng
hcfmusp.relation.referenceHahn, 2019, BH DUBOIS LUPUS ERYT, P137eng
hcfmusp.relation.referenceJaligama S, 2018, PART FIBRE TOXICOL, V15, DOI 10.1186/s12989-018-0255-3eng
hcfmusp.relation.referenceJung CR, 2019, SCI TOTAL ENVIRON, V668, P342, DOI 10.1016/j.scitotenv.2019.03.018eng
hcfmusp.relation.referenceKlumper C, 2015, ENVIRON RES, V138, P381, DOI 10.1016/j.envres.2015.02.034eng
hcfmusp.relation.referenceLLORENTE L, 1995, J EXP MED, V181, P839, DOI 10.1084/jem.181.3.839eng
hcfmusp.relation.referenceMa QY, 2017, INT IMMUNOPHARMACOL, V50, P139, DOI 10.1016/j.intimp.2017.06.019eng
hcfmusp.relation.referenceMatthews NC, 2016, AM J RESP CELL MOL, V54, P250, DOI 10.1165/rcmb.2015-0084OCeng
hcfmusp.relation.referenceMousavi SE, 2017, MED HYPOTHESES, V100, P23, DOI 10.1016/j.mehy.2017.01.003eng
hcfmusp.relation.referenceOrione MAM, 2014, ARTHRIT CARE RES, V66, P1571, DOI 10.1002/acr.22358eng
hcfmusp.relation.referenceFranca CMP, 2018, J RHEUMATOL, V45, P248, DOI 10.3899/jrheum.161500eng
hcfmusp.relation.referencePark YB, 1998, CLIN EXP RHEUMATOL, V16, P283eng
hcfmusp.relation.referencePope CA, 2016, CIRC RES, V119, P1204, DOI 10.1161/CIRCRESAHA.116.309279eng
hcfmusp.relation.referenceReis H, 2018, ENVIRON INT, V114, P252, DOI 10.1016/j.envint.2018.02.042eng
hcfmusp.relation.referenceRonnelid J, 2003, ANN RHEUM DIS, V62, P37, DOI 10.1136/ard.62.1.37eng
hcfmusp.relation.referenceRose T, 2017, BEST PRACT RES CL RH, V31, P321, DOI 10.1016/j.berh.2017.09.007eng
hcfmusp.relation.referenceSharif MN, 2004, J IMMUNOL, V172, P6476, DOI 10.4049/jimmunol.172.10.6476eng
hcfmusp.relation.referenceSun G, 2016, INT J RHEUMATOL, V2016, DOI 10.1155/2016/5356307eng
hcfmusp.relation.referenceVidotto JP, 2012, LUPUS, V21, P526, DOI 10.1177/0961203312437806eng
hcfmusp.relation.referenceVillarreal-Calderon R, 2012, J TOXICOL PATHOL, V25, P163, DOI 10.1293/tox.25.163eng
hcfmusp.relation.referenceVillarreal-Calderon R, 2012, EXP TOXICOL PATHOL, V64, P297, DOI 10.1016/j.etp.2010.09.002eng
hcfmusp.relation.referenceZeft AS, 2016, CLIN EXP RHEUMATOL, V34, P946eng
hcfmusp.relation.referenceZhao CN, 2019, AUTOIMMUN REV, V18, P607, DOI 10.1016/j.autrev.2018.12.010eng
hcfmusp.scopus.lastupdate2024-05-10
relation.isAuthorOfPublication739ea119-252c-4c32-b7b0-876d2d86a386
relation.isAuthorOfPublication7b792542-e8f8-45fd-8597-2ebfb8d874d6
relation.isAuthorOfPublication3901362a-4da9-4d92-a3b1-8dabee682488
relation.isAuthorOfPublicatione43d8f22-42d2-4c0e-8aa8-0518403cf495
relation.isAuthorOfPublication63e37f83-0f1d-4aad-b1bc-cd8c8a19810c
relation.isAuthorOfPublicationf4a01210-82ac-45c8-a5d6-62dc15444465
relation.isAuthorOfPublication6c3c5459-9dbb-4a5c-98b1-d7b76943b87d
relation.isAuthorOfPublication.latestForDiscovery739ea119-252c-4c32-b7b0-876d2d86a386
Arquivos
Pacote Original
Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
art_FARHAT_Air_pollution_influence_on_serum_inflammatory_interleukins_A_2021.PDF
Tamanho:
862.73 KB
Formato:
Adobe Portable Document Format
Baixar
Coleções
Artigos e Materiais de Revistas Científicas - FM/MPE
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/ICr
Artigos e Materiais de Revistas Científicas - LIM/05
Artigos e Materiais de Revistas Científicas - LIM/36
Artigos e Materiais de Revistas Científicas - ODS/03
Carregar mais