A New Insight into the Surgical Treatment of Primary Macronodular Adrenal Hyperplasia

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorTANNO, Fabio Yoshiaki
dc.contributor.authorSROUGI, Victor
dc.contributor.authorALMEIDA, Madson Q.
dc.contributor.authorYAMAUCHI, Fernando Ide
dc.contributor.authorCOELHO, Fernando Morbeck Almeida
dc.contributor.authorNISHI, Mirian Yumie
dc.contributor.authorZERBINI, Maria Claudia Nogueira
dc.contributor.authorSOARES, Iracy Silvia Correa
dc.contributor.authorPEREIRA, Maria Adelaide Albergaria
dc.contributor.authorCHARCHAR, Helaine Laiz Silva
dc.contributor.authorLACOMBE, Amanda Meneses Ferreira
dc.contributor.authorBRONDANI, Vania Balderrama
dc.contributor.authorSROUGI, Miguel
dc.contributor.authorNAHAS, Willian Carlos
dc.contributor.authorMENDONCA, Berenice B.
dc.contributor.authorCHAMBO, Jose Luis
dc.contributor.authorFRAGOSO, Maria Candida Barisson Villares
dc.date.accessioned2020-10-15T14:38:38Z
dc.date.available2020-10-15T14:38:38Z
dc.date.issued2020
dc.description.abstractPurpose: This prospective study presents the results of a new approach in the treatment of primary macronodular adrenal hyperplasia (PMAII), with simultaneous total adrenalectomy of the larger adrenal gland and partial adrenalectomy of the contralateral adrenal gland (adrenal-sparing surgery). Materials and Methods: We performed a prospective study including 17 patients with PMAH treated surgically with adrenal-sparing surgery in a tertiary referral hospital, with a median follow-up of 41 months. Clinical, hormonal, and genetic parameters were evaluated before surgery and during follow-up. All patients had at least 1 radiological examination before and after the procedure. Results: Among the 17 patients, all but 1 patient had complete hypercortisolism control, and 12 recovered normal adrenal function after surgery. Significant improvement in clinical parameters was observed: weight loss (P = .004); reduction of both systolic (P = .001) and diastolic (P = .001) blood pressure; and reduction in the number of antihypertensive drugs (P < .001). Intra-, peri-, and postoperative complications were not observed. Conclusion: Adrenal-sparing surgery is a safe and feasible procedure to treat patients with PMAH, providing a substantial chance of hypercortisolism control without the disadvantages of lifetime corticosteroid replacement. (C) Endocrine Society 2020.eng
dc.description.indexPubMedeng
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2015/50192-9]
dc.identifier.citationJOURNAL OF THE ENDOCRINE SOCIETY, v.4, n.8, article ID bvaa083, 14p, 2020
dc.identifier.doi10.1210/jendso/bvaa083
dc.identifier.eissn2472-1972
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/37888
dc.language.isoeng
dc.publisherENDOCRINE SOCeng
dc.relation.ispartofJournal of the Endocrine Society
dc.rightsopenAccesseng
dc.rights.holderCopyright ENDOCRINE SOCeng
dc.subjectPMAHeng
dc.subjectpartial adrenalectomyeng
dc.subjecthypercortisolismeng
dc.subjectadrenal surgeryeng
dc.subjectARMC5eng
dc.subject.othercushings-syndromeeng
dc.subject.othersubclinical hypercortisolismeng
dc.subject.otherunilateral adrenalectomyeng
dc.subject.otherarmc5 mutationseng
dc.subject.otherrecoveryeng
dc.subject.otherefficacyeng
dc.subject.otherdiseaseeng
dc.subject.wosEndocrinology & Metabolismeng
dc.titleA New Insight into the Surgical Treatment of Primary Macronodular Adrenal Hyperplasiaeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.citation.scopus17
hcfmusp.contributor.author-fmusphcFABIO YOSHIAKI TANNO
hcfmusp.contributor.author-fmusphcVICTOR SROUGI
hcfmusp.contributor.author-fmusphcMADSON QUEIROZ DE ALMEIDA
hcfmusp.contributor.author-fmusphcFERNANDO IDE YAMAUCHI
hcfmusp.contributor.author-fmusphcFERNANDO MORBECK ALMEIDA COELHO
hcfmusp.contributor.author-fmusphcMIRIAN YUMIE NISHI
hcfmusp.contributor.author-fmusphcMARIA CLAUDIA NOGUEIRA ZERBINI
hcfmusp.contributor.author-fmusphcIRACY SILVIA CORREA SOARES
hcfmusp.contributor.author-fmusphcMARIA ADELAIDE ALBERGARIA PEREIRA
hcfmusp.contributor.author-fmusphcHELAINE LAIZ SILVA CHARCHAR
hcfmusp.contributor.author-fmusphcAMANDA MENESES FERREIRA LACOMBE
hcfmusp.contributor.author-fmusphcVANIA BALDERRAMA BRONDANI
hcfmusp.contributor.author-fmusphcMIGUEL SROUGI
hcfmusp.contributor.author-fmusphcWILLIAM CARLOS NAHAS
hcfmusp.contributor.author-fmusphcBERENICE BILHARINHO DE MENDONCA
hcfmusp.contributor.author-fmusphcJOSE LUIS CHAMBO
hcfmusp.contributor.author-fmusphcMARIA CANDIDA BARISSON VILLARES FRAGOSO
hcfmusp.description.articlenumberbvaa083
hcfmusp.description.issue8
hcfmusp.description.volume4
hcfmusp.origemWOS
hcfmusp.origem.pubmed32724871
hcfmusp.origem.scopus2-s2.0-85090567712
hcfmusp.origem.wosWOS:000555560900010
hcfmusp.publisher.cityWASHINGTONeng
hcfmusp.publisher.countryUSAeng
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hcfmusp.scopus.lastupdate2024-05-17
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