Association between Dietary Intake and Coronary Artery Calcification in Non-Dialysis Chronic Kidney Disease: The PROGREDIR Study

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Citações na Scopus
21
Tipo de produção
article
Data de publicação
2018
Título da Revista
ISSN da Revista
Título do Volume
Editora
MDPI
Autores
MARCHIONI, Dirce Maria Lobo
ANJOS, Fernanda Silva Nogueira dos
MOLINA, Maria del Carmen Bisi
Citação
NUTRIENTS, v.10, n.3, article ID 372, 13p, 2018
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Coronary artery calcification (CAC) is a widespread condition in chronic kidney disease (CKD). Diet may play an important role in CAC, but this role is not clear. This study evaluated the association between macro-and micronutrient intakes and CAC in non-dialysis CKD patients. We analyzed the baseline data from 454 participants of the PROGREDIR study. Dietary intake was evaluated by a food frequency questionnaire. CAC was measured by computed tomography. After exclusion of participants with a coronary stent, 373 people remained for the analyses. The highest tertile of CAC was directly associated with the intake of phosphorus, calcium and magnesium. There was a higher intake of pantothenic acid and potassium in the second tertile. After adjustments for confounding variables, the intake of pantothenic acid, phosphorus, calcium and potassium remained associated with CAC in the generalized linear mixed models. In order to handle the collinearity between these nutrients, we used the LASSO (least absolute shrinkage and selection operator) regression to evaluate the nutrients associated with CAC variability. In this approach, the nutrients that most explained the variance of CAC were phosphorus, calcium and potassium. Prospective studies are needed to confirmthese findings and assess the role of interventions regarding these micronutrients on CAC prevention and progression.
Palavras-chave
vascular calcification, diet, micronutrients, phosphorus, calcium, potassium, renal insufficiency, chronic, health surveys
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