Adverse events of nucleos(t)ide analogues for chronic hepatitis B: a systematic review

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorFRAGA, Raquel Scherer de
dc.contributor.authorVAISBERG, Victor Van
dc.contributor.authorMENDES, Luiz Claudio Alfaia
dc.contributor.authorCARRILHO, Flair Jose
dc.contributor.authorONO, Suzane Kioko
dc.date.accessioned2020-06-01T14:52:45Z
dc.date.available2020-06-01T14:52:45Z
dc.date.issued2020
dc.description.abstractNucleos(t)ide analogues (NAs) are the main drug category used in chronic hepatitis B (CHB) treatment. Despite the fact that NAs have a favourable safety profile, undesired adverse events (AEs) may occur during the treatment of CHB. Given the eminent number of patients currently receiving NAs, even a small risk of any of these toxicities can represent a major medical issue. The main objective of this review was to analyse information available on AEs associated with the use of NAs in published studies. We choose the following MesH terms for this systematic review: chronic hepatitis B, side effects and treatment. All articles published from 1 January 1990 up to 19 February 2018 in MEDLINE of PubMed, EMBASE, the Cochrane Library and LILACS databases were searched. A total of 120 articles were selected for analysis, comprising 6419 patients treated with lamivudine (LAM), 5947 with entecavir (ETV), 3566 with tenofovir disoproxil fumarate (TDF), 3096 with telbivudine (LdT), 1178 with adefovir dipivoxil (ADV) and 876 with tenofovir alafenamide (TAF). The most common AEs in all NAs assessed were abdominal pain/discomfort, nasopharyngitis/upper respiratory tract infections, fatigue, and headache. TAF displays the highest density of AEs per patient treated among NAs (1.14 AE/treated patient). In conclusion, treatment of CHB with NAs is safe, with a low incidence of AEs. Despite the general understanding TAF being safer than TDF, the number of patients treated with TAF still is too small in comparison to other NAs to consolidate an accurate safety profile. PROSPERO Registration No. CRD42018086471eng
dc.description.indexMEDLINEeng
dc.description.sponsorshipBrazilian Council for Development of Science and Technology (CNPq)National Council for Scientific and Technological Development (CNPq) [PQ 308609/2018-2]
dc.identifier.citationJOURNAL OF GASTROENTEROLOGY, v.55, n.5, p.496-514, 2020
dc.identifier.doi10.1007/s00535-020-01680-0
dc.identifier.eissn1435-5922
dc.identifier.issn0944-1174
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/35962
dc.language.isoeng
dc.publisherSPRINGER JAPAN KKeng
dc.relation.ispartofJournal of Gastroenterology
dc.rightsopenAccesseng
dc.rights.holderCopyright SPRINGER JAPAN KKeng
dc.subjectChronic hepatitis Beng
dc.subjectNucleotideeng
dc.subjectnucleoside analogueseng
dc.subjectAdverse eventseng
dc.subject.otherpositive chronic hepatitiseng
dc.subject.othertenofovir disoproxil fumarateeng
dc.subject.otherlong-term efficacyeng
dc.subject.otherpegylated interferon alpha-2aeng
dc.subject.otherextended lamivudine treatmenteng
dc.subject.otheradefovir dipivoxil therapyeng
dc.subject.othersurface-antigen carrierseng
dc.subject.otheroral antiviral therapyeng
dc.subject.otherearly viral kineticseng
dc.subject.otherone-year trialeng
dc.subject.wosGastroenterology & Hepatologyeng
dc.titleAdverse events of nucleos(t)ide analogues for chronic hepatitis B: a systematic revieweng
dc.typearticleeng
dc.type.categoryrevieweng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.citation.scopus28
hcfmusp.contributor.author-fmusphcRAQUEL SCHERER DE FRAGA
hcfmusp.contributor.author-fmusphcVICTOR VAN VAISBERG
hcfmusp.contributor.author-fmusphcLUIS CLAUDIO ALFAIA MENDES
hcfmusp.contributor.author-fmusphcFLAIR JOSE CARRILHO
hcfmusp.contributor.author-fmusphcSUZANE KIOKO ONO
hcfmusp.description.beginpage496
hcfmusp.description.endpage514
hcfmusp.description.issue5
hcfmusp.description.volume55
hcfmusp.origemWOS
hcfmusp.origem.pubmed32185517
hcfmusp.origem.scopus2-s2.0-85082752919
hcfmusp.origem.wosWOS:000520633400001
hcfmusp.publisher.cityTOKYOeng
hcfmusp.publisher.countryJAPANeng
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