Association of IFNL3 and IFNL4 polymorphisms with hepatitis C virus infection in a population from southeastern Brazil

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorNASTRI, Ana Catharina de Seixas Santos
dc.contributor.authorMALTA, Fernanda de Mello
dc.contributor.authorDINIZ, Marcio Augusto
dc.contributor.authorYOSHINO, Alessandra
dc.contributor.authorABE-SANDES, Kiyoko
dc.contributor.authorSANTOS, Sidney Emanuel Batista dos
dc.contributor.authorLYRA, Andre de Castro
dc.contributor.authorCARRILHO, Flair Jose
dc.contributor.authorPINHO, Joao Renato Rebello
dc.date.accessioned2016-07-18T12:12:52Z
dc.date.available2016-07-18T12:12:52Z
dc.date.issued2016
dc.description.abstractHepatitis C virus (HCV) infection is a major cause of chronic liver disease and associated complications such as liver cirrhosis and hepatocellular carcinoma (HCC). Viral and host factors are known to be predictors for antiviral therapy. Host factors that are predictors of sustained viral response (SVR) were discovered by genome-wide association studies (GWAS), including single-nucleotide polymorphisms (SNPs) in or near the interferon lambda gene (rs8099917, rs12979860 and rs368234815). The aim of the present study was to verify the genotype frequencies of SNPs rs8099917, rs12979860 and rs368234815 and to evaluate the association between SNPs and the outcome of HCV infection, taking into account the population ancestry. In this study, there was an association of the three polymorphisms with both clinical outcome and response to treatment with PEG-IFN and RBV. The polymorphisms rs12979860 and rs368234815 were associated with increased sensitivity (97.7 %, 95 % CI 87.2-100, and 93.3 %, 95 % CI 81.3-98.3; respectively) and with a greater predictive value of a positive response to treatment. In multivariable analysis adjusted by gender, age and ancestry, the haplotype G/T/Delta G was related to non-response to treatment (OR = 21.09, 95 % CI 5.33-83.51; p < 0.001) and to a higher chance of developing chronic infection (OR = 5.46, 95 % CI 2.06-14.46; p = 0.001) when compared to the haplotype T/C/TT. These findings may help to adjust our treatment policies for HCV infection based on greater certainty in studies with populations with such genetic characteristics, as well as allowing us to get to know the genetic profile of our population for these polymorphisms.
dc.description.indexMEDLINE
dc.description.sponsorshipFapesp [2010/10.549-1]
dc.description.sponsorshipAlves de Queiroz Family Fund for Research
dc.description.sponsorshipCNPq (Bolsista de Produtividade em Pesquisa do CNPq - Nivel 2)
dc.identifier.citationARCHIVES OF VIROLOGY, v.161, n.6, p.1477-1484, 2016
dc.identifier.doi10.1007/s00705-016-2809-8
dc.identifier.eissn1432-8798
dc.identifier.issn0304-8608
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/14239
dc.language.isoeng
dc.publisherSPRINGER WIEN
dc.relation.ispartofArchives of Virology
dc.rightsrestrictedAccess
dc.rights.holderCopyright SPRINGER WIEN
dc.subject.othertreatment-naive patients
dc.subject.othergenome-wide association
dc.subject.othergenetic-variation
dc.subject.otheril28b
dc.subject.otherclearance
dc.subject.otherribavirin
dc.subject.otherancestry
dc.subject.otherphase
dc.subject.otherhcv
dc.subject.othersubstructure
dc.subject.wosVirology
dc.titleAssociation of IFNL3 and IFNL4 polymorphisms with hepatitis C virus infection in a population from southeastern Brazil
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryisous
hcfmusp.author.externalDINIZ, Marcio Augusto:Cedars Sinai Med Ctr, Samuel Oschin Canc Inst, Los Angeles, CA 90048 USA
hcfmusp.author.externalABE-SANDES, Kiyoko:Fed Univ Bahia UFBA, Hlth Sci Inst ICS, Immunol Lab, Salvador, BA, Brazil
hcfmusp.author.externalSANTOS, Sidney Emanuel Batista dos:Fed Univ Bahia UFBA, Dept Med, Salvador, BA, Brazil
hcfmusp.author.externalLYRA, Andre de Castro:Fed Univ Para UFPA, Human Genet & Med Lab, Belem, Para, Brazil
hcfmusp.citation.scopus9
hcfmusp.contributor.author-fmusphcANA CATHARINA DE SEIXAS SANTOS NASTRI
hcfmusp.contributor.author-fmusphcFERNANDA DE MELLO MALTA
hcfmusp.contributor.author-fmusphcALESSANDRA YOSHINO
hcfmusp.contributor.author-fmusphcFLAIR JOSE CARRILHO
hcfmusp.contributor.author-fmusphcJOAO RENATO REBELLO PINHO
hcfmusp.description.beginpage1477
hcfmusp.description.endpage1484
hcfmusp.description.issue6
hcfmusp.description.volume161
hcfmusp.origemWOS
hcfmusp.origem.pubmed26973228
hcfmusp.origem.scopus2-s2.0-84961137337
hcfmusp.origem.wosWOS:000376405500006
hcfmusp.publisher.cityWIEN
hcfmusp.publisher.countryAUSTRIA
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