Multicenter Voxel-Based Morphometry Mega-Analysis of Structural Brain Scans in Obsessive-Compulsive Disorder

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorWIT, Stella J. de
dc.contributor.authorALONSO, Pino
dc.contributor.authorSCHWEREN, Lizanne
dc.contributor.authorMATAIX-COLS, David
dc.contributor.authorLOCHNER, Christine
dc.contributor.authorMENCHON, Jose M.
dc.contributor.authorSTEIN, Dan J.
dc.contributor.authorFOUCHE, Jean-Paul
dc.contributor.authorSORIANO-MAS, Caries
dc.contributor.authorSATO, Joao R.
dc.contributor.authorHOEXTER, Marcelo Q.
dc.contributor.authorDENYS, Damiaan
dc.contributor.authorNAKAMAE, Takashi
dc.contributor.authorNISHIDA, Seiji
dc.contributor.authorKWON, Jun Soo
dc.contributor.authorJANG, Joon Hwan
dc.contributor.authorBUSATTO, Geraldo F.
dc.contributor.authorCARDONER, Narcis
dc.contributor.authorCATH, Danielle C.
dc.contributor.authorFUKUI, Kenji
dc.contributor.authorJUNG, Wi Hoon
dc.contributor.authorKIM, Sung Nyun
dc.contributor.authorMIGUEL, Euripides C.
dc.contributor.authorNARUMOTO, Jin
dc.contributor.authorPHILLIPS, Mary L.
dc.contributor.authorPUJOL, Jesus
dc.contributor.authorREMIJNSE, Peter L.
dc.contributor.authorSAKAI, Yuki
dc.contributor.authorSHIN, Na Young
dc.contributor.authorYAMADA, Kei
dc.contributor.authorVELTMAN, Dick J.
dc.contributor.authorHEUVEL, Odile A. van den
dc.date.accessioned2014-04-28T22:04:23Z
dc.date.available2014-04-28T22:04:23Z
dc.date.issued2014
dc.description.abstractObjective: Results from structural neuroimaging studies of obsessive-compulsive disorder (OCD) have been only partially consistent. The authors sought to assess regional gray and white matter volume differences between large samples of OCD patients and healthy comparison subjects and their relation with demographic and clinical variables. Method: A multicenter voxel-based morphometry mega-analysis was performed on 1.5-T str.uctural T-1-weighted MRI scans derived from the International OCD Brain Imaging Consortium. Regional gray and white matter brain volumes were compared between 412 adult OCD patients and 368 healthy subjects. Results: Relative to healthy comparison subjects, OCD patients had significantly smaller volumes of frontal gray and white matter bilaterally, including the dorsomedial prefrontal cortex, the anterior cingulate cortex, and the inferior frontal gyrus extending to the anterior insula. Patients also showed greater cerebellar gray matter volume bilaterally compared with healthy subjects. Group differences in frontal gray and white matter volume were significant after correction for multiple comparisons. Additionally, group-by-age interactions were observed in the putamen, insula, and orbitofrontal cortex (indicating relative preservation of volume in patients compared with healthy subjects with increasing age) and in the temporal cortex bilaterally (indicating a relative loss of volume in patients compared. with healthy subjects with increasing age). Conclusions: These findings partially support the prevailing fronto-striatal models of OCD and offer additional insights into the neuroanatomy of the disorder that were not apparent from previous smaller studies. The group-by-age interaction effects. in orbitofrontal-striatal and (para)limbic brain regions may be the result of altered neuroplasticity associated with chronic compulsive behaviors, anxiety, or compensatory processes related to cognitive dysfunction.
dc.description.indexMEDLINE
dc.description.sponsorshipDutch Organization for Scientific Research (NWO) [912-02-050, 907-00-012, 940-37-018, 916.86.038]
dc.description.sponsorshipCarlos III Health Institute [PI09/01331, PI10/01753, PI10/01003, CP10/00604, CIBER-CB06/03/0034]
dc.description.sponsorshipAgency for Administration of University and Research (AGAUR, Barcelona) [2009SGR1554]
dc.description.sponsorshipMiguel Servet contract from the Carlos III Health Institute [CP10/00604]
dc.description.sponsorshipMinistry of Education, Culture, Sports, Science, and Technology (Japan) [23591724, 24791223]
dc.description.sponsorshipWellcome Trust [064846]
dc.description.sponsorshipFoundation for the Support of Research in the State of Sao Paulo (FAPESP) [2005/55628-8]
dc.description.sponsorshipFAPESP scholarship [2005/04206-6]
dc.description.sponsorshipNational Research Foundation of Korea
dc.description.sponsorshipKorean government (Ministry of Education, Science, and Technology) [2012-0005150]
dc.identifier.citationAMERICAN JOURNAL OF PSYCHIATRY, v.171, n.3, p.340-349, 2014
dc.identifier.doi10.1176/appi.ajp.2013.13040574
dc.identifier.eissn1535-7228
dc.identifier.issn0002-953X
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/5431
dc.language.isoeng
dc.publisherAMER PSYCHIATRIC PUBLISHING, INC
dc.relation.ispartofAmerican Journal of Psychiatry
dc.rightsrestrictedAccess
dc.rights.holderCopyright AMER PSYCHIATRIC PUBLISHING, INC
dc.subject.othermatter abnormalities
dc.subject.otheranxiety disorders
dc.subject.otherhuman emotion
dc.subject.othermri
dc.subject.othermetaanalysis
dc.subject.othervolumes
dc.subject.otherschizophrenia
dc.subject.otherhyperactivity
dc.subject.othercerebellum
dc.subject.otherdepression
dc.subject.wosPsychiatry
dc.titleMulticenter Voxel-Based Morphometry Mega-Analysis of Structural Brain Scans in Obsessive-Compulsive Disorder
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.affiliation.countryHolanda
hcfmusp.affiliation.countryisonl
hcfmusp.author.externalHEUVEL, Odile A. van den:Vrije Univ Amsterdam, Med Ctr, Dept Psychiat, Amsterdam, Netherlands
hcfmusp.citation.scopus214
hcfmusp.contributor.author-fmusphcJOAO RICARDO SATO
hcfmusp.contributor.author-fmusphcMARCELO QUEIROZ HOEXTER
hcfmusp.contributor.author-fmusphcGERALDO BUSATTO FILHO
hcfmusp.contributor.author-fmusphcEURIPEDES CONSTANTINO MIGUEL FILHO
hcfmusp.description.beginpage340
hcfmusp.description.endpage349
hcfmusp.description.issue3
hcfmusp.description.volume171
hcfmusp.origemWOS
hcfmusp.origem.pubmed24220667
hcfmusp.origem.scopus2-s2.0-84898763017
hcfmusp.origem.wosWOS:000332348400013
hcfmusp.publisher.cityARLINGTON
hcfmusp.publisher.countryUSA
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hcfmusp.remissive.sponsorshipFAPESP
hcfmusp.remissive.sponsorshipWellcome Trust
hcfmusp.remissive.sponsorshipInstituto de Salud Carlos III
hcfmusp.scopus.lastupdate2024-04-12
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