Clinical neurotransplantation protocol for Huntington's and Parkinson's disease

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorLOPEZ, William Omar Contreras
dc.contributor.authorNIKKHAH, Guido
dc.contributor.authorKAHLERT, Ulf D.
dc.contributor.authorMACIACZYK, Donata
dc.contributor.authorBOGIEL, Tomasz
dc.contributor.authorMOELLERS, Sven
dc.contributor.authorSCHUELTKE, Elisabeth
dc.contributor.authorDOEBROESSY, Mate
dc.contributor.authorMACIACZYK, Jaroslaw
dc.date.accessioned2014-04-25T21:55:15Z
dc.date.available2014-04-25T21:55:15Z
dc.date.issued2013
dc.description.abstractPurpose: The concept of transplantation of neuronal cells to treat Huntington's and Parkinson's diseases is based on the proven principle that dopaminergic and GABA-ergic progenitor neurons (from the human developing ventral mesencephalon and whole ganglionic eminence) can survive, differentiate and functionally integrate into an allogenic host brain. However, several donor and host-specific variables play a major role in the safety and outcome of this procedure. In this paper, we seek to summarize an updated neural transplantation protocol, based on our institutional experience and many years of collaboration with other neurotransplantation centers. Methods: We present a detailed clinical neurotransplantation protocol for Parkinson's (PD) and Huntington's (HD) diseases with special emphasis in understanding the anatomical relationships of the human fetal tissue that are relevant for selection of the desired cell populations. Results: Two detailed step-wise neurotransplantation protocols are presented, outlining strategies facilitating the avoidance of possible procedure-related complications. Conclusions: In this paper we delineated some crucial technical factors enabling the execution of a safe and effective neural transplantation. The protocols presented here might contribute to further development of the experimental clinical neurotransplantation towards a routine therapeutic procedure.
dc.description.indexMEDLINE
dc.identifier.citationRESTORATIVE NEUROLOGY AND NEUROSCIENCE, v.31, n.5, p.579-595, 2013
dc.identifier.doi10.3233/RNN-130317
dc.identifier.issn0922-6028
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/5196
dc.language.isoeng
dc.publisherIOS PRESS
dc.relation.ispartofRestorative Neurology and Neuroscience
dc.rightsrestrictedAccess
dc.rights.holderCopyright IOS PRESS
dc.subjectHuman fetal neural precursor cells (hFNPCs)
dc.subjectneural stem cells (NSC)
dc.subjectventral mesencephalon (VM)
dc.subjectwhole ganglionic eminence (WGE)
dc.subjectsubstantia nigra (SN)
dc.subjectParkinson's disease (PD)
dc.subjectHuntington's disease (HD)
dc.subjectgood clinical practice (GCP)
dc.subject.otherfetal nigral transplantation
dc.subject.othermediated functional recovery
dc.subject.othermesencephalic tissue
dc.subject.otherneural transplantation
dc.subject.othercaudate-nucleus
dc.subject.otherdopaminergic grafts
dc.subject.otherstriatal grafts
dc.subject.otherrodent model
dc.subject.otherstem-cells
dc.subject.otherin-vivo
dc.subject.wosNeurosciences
dc.titleClinical neurotransplantation protocol for Huntington's and Parkinson's disease
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.affiliation.countryAlemanha
hcfmusp.affiliation.countryPolônia
hcfmusp.affiliation.countryisode
hcfmusp.affiliation.countryisopl
hcfmusp.author.externalNIKKHAH, Guido:Univ Freiburg, Med Ctr, Dept Stereotact & Funct Neurosurg, Freiburg, Germany; Univ Erlangen Nurnberg, Dept Neurosurg, Erlangen, Germany
hcfmusp.author.externalKAHLERT, Ulf D.:Univ Freiburg, Med Ctr, Dept Stereotact & Funct Neurosurg, Freiburg, Germany
hcfmusp.author.externalMACIACZYK, Donata:Univ Freiburg, Med Ctr, Dept Stereotact & Funct Neurosurg, Freiburg, Germany
hcfmusp.author.externalBOGIEL, Tomasz:Univ Freiburg, Med Ctr, Dept Stereotact & Funct Neurosurg, Freiburg, Germany; Dept Pathomorphol, Lab Clin Genet, Bydgoszcz, Poland; Nicolaus Copernicus Univ Torun, Ludwik Rydygier Coll Med Bydgoszcz, Dept Microbiol, Bydgoszcz, Poland
hcfmusp.author.externalMOELLERS, Sven:Univ Freiburg, Med Ctr, Dept Stereotact & Funct Neurosurg, Freiburg, Germany
hcfmusp.author.externalSCHUELTKE, Elisabeth:Univ Freiburg, Med Ctr, Dept Stereotact & Funct Neurosurg, Freiburg, Germany
hcfmusp.author.externalDOEBROESSY, Mate:Univ Freiburg, Med Ctr, Dept Stereotact & Funct Neurosurg, Freiburg, Germany
hcfmusp.author.externalMACIACZYK, Jaroslaw:Univ Freiburg, Med Ctr, Dept Gen Neurosurg, Freiburg, Germany; Univ Dusseldorf, Dept Neurosurg, Div Funct Neurosurg, D-40225 Dusseldorf, Germany
hcfmusp.citation.scopus11
hcfmusp.contributor.author-fmusphcWILLIAM OMAR CONTRERAS LOPEZ
hcfmusp.description.beginpage579
hcfmusp.description.endpage595
hcfmusp.description.issue5
hcfmusp.description.volume31
hcfmusp.origemWOS
hcfmusp.origem.pubmed23777636
hcfmusp.origem.scopus2-s2.0-84883870483
hcfmusp.origem.wosWOS:000324262100006
hcfmusp.publisher.cityAMSTERDAM
hcfmusp.publisher.countryNETHERLANDS
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