Interleukin 10 (IL10) and transforming growth factor beta 1 (TGF beta 1) gene polymorphisms in persistent IgE-mediated cow's milk allergy
dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | |
dc.contributor.author | JACOB, Cristina Miuki Abe | |
dc.contributor.author | PASTORINO, Antonio Carlos | |
dc.contributor.author | OKAY, Thelma Suely | |
dc.contributor.author | CASTRO, Ana Paula B. M. | |
dc.contributor.author | GUSHKEN, Andrea Keiko F. | |
dc.contributor.author | WATANABE, Leticia Aki | |
dc.contributor.author | FRUCCHI, Vanessa C. Z. | |
dc.contributor.author | OLIVEIRA, Lea Campos de | |
dc.date.accessioned | 2014-01-28T22:25:56Z | |
dc.date.available | 2014-01-28T22:25:56Z | |
dc.date.issued | 2013 | |
dc.description.abstract | OBJECTIVES: The aim of this cross-sectional study was to evaluate whether interleukin 10 (IL10) and transforming growth factor beta 1 (TGF beta 1) gene polymorphisms were associated with persistent IgE-mediated cow's milk allergy in 50 Brazilian children. The diagnostic criteria were anaphylaxis triggered by cow's milk or a positive double-blind, placebo-controlled food challenge. Tolerance was defined as the absence of a clinical response to a double-blind, placebo-controlled food challenge or cow's milk exposure. METHOD: The genomic DNA of the 50 patients and 224 healthy controls (HCs) was used to investigate five IL10 gene polymorphisms (-3575A/T, -2849A/G, -2763A/C, -1082G/A, -592C/A) and one TGF beta 1 polymorphism (-509C/T). RESULTS: Among the five IL10 polymorphisms analyzed, homozygosis for the G allele at the -1082 position was significantly higher in the patients compared with the healthy controls (p = 0.027) and in the persistent cow's milk allergy group compared with the healthy controls (p = 0.001). CONCLUSIONS: Homozygosis for the G allele at the IL10 -1082G/A polymorphism is associated with the persistent form of cow's milk allergy. | |
dc.description.index | MEDLINE | |
dc.description.sponsorship | Conselho Nacional de Pesquisa - CNPq [475707/2007-9 - Edital - MCT/CNPq 15/2007, 308105/2012-5] | |
dc.identifier.citation | CLINICS, v.68, n.7, p.1004-1009, 2013 | |
dc.identifier.doi | 10.6061/clinics/2013(07)19 | |
dc.identifier.issn | 1807-5932 | |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/4174 | |
dc.language.iso | eng | |
dc.publisher | HOSPITAL CLINICAS, UNIV SAO PAULO | |
dc.relation.ispartof | Clinics | |
dc.rights | openAccess | |
dc.rights.holder | Copyright HOSPITAL CLINICAS, UNIV SAO PAULO | |
dc.subject | Food Hypersensitivity | |
dc.subject | Cow's Milk Allergy | |
dc.subject | Clinical Outcome | |
dc.subject | Gene Polymorphism | |
dc.subject | Interleukin 10 | |
dc.subject | Transforming Growth Factor beta 1 | |
dc.subject.other | single nucleotide polymorphisms | |
dc.subject.other | food allergy | |
dc.subject.other | promoter polymorphisms | |
dc.subject.other | atopic-dermatitis | |
dc.subject.other | t-cells | |
dc.subject.other | children | |
dc.subject.other | asthma | |
dc.subject.other | association | |
dc.subject.other | il-10 | |
dc.subject.other | population | |
dc.subject.wos | Medicine, General & Internal | |
dc.title | Interleukin 10 (IL10) and transforming growth factor beta 1 (TGF beta 1) gene polymorphisms in persistent IgE-mediated cow's milk allergy | |
dc.type | article | |
dc.type.category | original article | |
dc.type.version | publishedVersion | |
dspace.entity.type | Publication | |
hcfmusp.author.external | GUSHKEN, Andrea Keiko F.:Univ Sao Paulo, Fac Med, Dept Pediat, Allergy & Immunol Unit, Sao Paulo, Brazil | |
hcfmusp.author.external | WATANABE, Leticia Aki:Univ Sao Paulo, Fac Med, Dept Pediat, Allergy & Immunol Unit, Sao Paulo, Brazil | |
hcfmusp.author.external | FRUCCHI, Vanessa C. Z.:Univ Sao Paulo, Fac Med, Dept Pediat, Allergy & Immunol Unit, Sao Paulo, Brazil | |
hcfmusp.citation.scopus | 15 | |
hcfmusp.contributor.author-fmusphc | CRISTINA MIUKI ABE JACOB | |
hcfmusp.contributor.author-fmusphc | ANTONIO CARLOS PASTORINO | |
hcfmusp.contributor.author-fmusphc | THELMA SUELY OKAY | |
hcfmusp.contributor.author-fmusphc | ANA PAULA BELTRAN MOSCHIONE CASTRO | |
hcfmusp.contributor.author-fmusphc | LEA CAMPOS DE OLIVEIRA | |
hcfmusp.description.beginpage | 1004 | |
hcfmusp.description.endpage | 1009 | |
hcfmusp.description.issue | 7 | |
hcfmusp.description.volume | 68 | |
hcfmusp.origem | WOS | |
hcfmusp.origem.pubmed | 23917667 | |
hcfmusp.origem.scielo | SCIELO:S1807-59322013000701004 | |
hcfmusp.origem.scopus | 2-s2.0-84881035185 | |
hcfmusp.origem.wos | WOS:000322601600019 | |
hcfmusp.publisher.city | SAO PAULO | |
hcfmusp.publisher.country | BRAZIL | |
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hcfmusp.remissive.sponsorship | CNPq | |
hcfmusp.scopus.lastupdate | 2024-05-10 | |
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