Cervicovaginal cytology in patients undergoing pelvic radiotherapy using the Focalpoint system: results from the RODEO study

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSTEIN, Maira Degiovani
dc.contributor.authorFREGNANI, Jose Humberto T. G.
dc.contributor.authorSCAPULATEMPO-NETO, Cristovam
dc.contributor.authorLONGATTO-FILHO, Adhemar
dc.date.accessioned2015-07-01T21:05:18Z
dc.date.available2015-07-01T21:05:18Z
dc.date.issued2015
dc.description.abstractBackground: Evaluate the performance of the Focalpoint system in identifying and classifying cervical cytology alterations from samples collected from patients treated with Radiotherapy (RT). Methods: The reproducibility of manual and automated screening by cytotechnologists using the BD Focalpoint GS Imaging System was examined. Samples were collected from May 2010 to August 2011. Results: A total of 378 treated with RT and 8,967 cytology samples from patients without previous RT, were evaluated. The kappa values for cytological diagnoses read manually and automated in cases without previous RT were as follows: < ASC-H vs. >= ASC-H = 0.71; < LSIL vs. >= LSIL = 0.66; and < HSIL vs. >= HSIL = 0.67. The kappa for cytological diagnoses in post-RT women have showed: < ASC-H vs. >= ASC-H = 0.71; < LSIL vs. >= LSIL = 0.65; < HSIL vs. >= HSIL = 0.57. Conclusions: There was no significant difference among the kappa values we found. Post-RT cytology showed small diagnostic agreement between manual and automated examination. Virtual Slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_231
dc.description.indexMEDLINE
dc.description.sponsorshipBarretos Cancer Hospital
dc.identifier.citationDIAGNOSTIC PATHOLOGY, v.10, article ID 1, 5p, 2015
dc.identifier.doi10.1186/s13000-014-0231-7
dc.identifier.issn1746-1596
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/9591
dc.language.isoeng
dc.publisherBIOMED CENTRAL LTD
dc.relation.ispartofDiagnostic Pathology
dc.rightsopenAccess
dc.rights.holderCopyright BIOMED CENTRAL LTD
dc.subjectPap test
dc.subjectRadiotherapy
dc.subjectAutomation
dc.subjectFocalpoint
dc.subjectSurePath
dc.subject.otherliquid-based cytology
dc.subject.otherhuman-papillomavirus
dc.subject.othercervical-cancer
dc.subject.othergenomic amplification
dc.subject.othersmears
dc.subject.otherreproducibility
dc.subject.otherneoplasia
dc.subject.otherwomen
dc.subject.othergene
dc.subject.wosPathology
dc.titleCervicovaginal cytology in patients undergoing pelvic radiotherapy using the Focalpoint system: results from the RODEO study
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalSTEIN, Maira Degiovani:Pio XII Fdn, Barretos Canc Hosp, Dept Pathol, Barretos, Brazil
hcfmusp.author.externalFREGNANI, Jose Humberto T. G.:Pio XII Fdn, Barretos Canc Hosp, Dept Pathol, Barretos, Brazil; Pio XII Fdn, Barretos Canc Hosp, Mol Oncol Res Ctr, Barretos, Brazil
hcfmusp.author.externalSCAPULATEMPO-NETO, Cristovam:Pio XII Fdn, Barretos Canc Hosp, Dept Pathol, Barretos, Brazil; Pio XII Fdn, Barretos Canc Hosp, Mol Oncol Res Ctr, Barretos, Brazil
hcfmusp.citation.scopus4
hcfmusp.contributor.author-fmusphcADHEMAR LONGATTO FILHO
hcfmusp.description.articlenumber1
hcfmusp.description.volume10
hcfmusp.origemWOS
hcfmusp.origem.pubmed25591792
hcfmusp.origem.scopus2-s2.0-84939177540
hcfmusp.origem.wosWOS:000349792800001
hcfmusp.publisher.cityLONDON
hcfmusp.publisher.countryENGLAND
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