Radiographic Characteristics of Adrenal Masses Preceding the Diagnosis of Adrenocortical Cancer

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorNOGUEIRA, T. M.
dc.contributor.authorLIROV, R.
dc.contributor.authorCAOILI, E. M.
dc.contributor.authorLERARIO, A. M.
dc.contributor.authorMILLER, B. S.
dc.contributor.authorFRAGOSO, M. C. B. V.
dc.contributor.authorDUNNICK, N. R.
dc.contributor.authorHAMMER, G. D.
dc.contributor.authorELSE, T.
dc.date.accessioned2015-10-26T16:48:41Z
dc.date.available2015-10-26T16:48:41Z
dc.date.issued2015
dc.description.abstractIncidentally discovered adrenal masses are common and the clinical evaluation and surveillance aims to diagnose hormone excess and malignancy. Adrenocortical cancer (ACC) is a very rare malignancy. This study aims to define the imaging characteristics of adrenal tumors preceding the diagnosis of ACC. Patients with prior (> 5 months) adrenal tumors (< 6 cm) subsequently diagnosed with ACC were identified in a large registry at a tertiary referral center. Retrospective chart and image review for patient characteristics and initial, interval, and diagnostic imaging characteristics (size, homogeneity, borders, density, growth rate, etc.) was conducted. Twenty patients with a diagnosis of ACC and a prior adrenal tumor were identified among 422 patients with ACC. Of these, 17 patients were initially imaged with CT and 3 with MR. Only 2 of the 20 patients had initial imaging characteristics suggestive of a benign lesion. Of initial tumors, 25 % were < 2 cm in size. Surveillance led to the diagnosis of ACC within 24 months in 50 % of patients. The growth pattern was variable with some lesions showing long-term stability (up to 8 years) in size. In conclusion, antecedent lesions in patients with a diagnosis of ACC are often indeterminate by imaging criteria and can be small. Surveillance over 2 years detected only 50 % of ACCs. Current practice and guidelines are insufficient in diagnosing ACCs. Given the rarity of ACC, the increased risk and health care costs of additional evaluation may not be warranted.
dc.description.indexMEDLINE
dc.description.sponsorship[T32-DK007245]
dc.identifier.citationHORMONES & CANCER, v.6, n.4, p.176-181, 2015
dc.identifier.doi10.1007/s12672-015-0225-2
dc.identifier.eissn1868-8500
dc.identifier.issn1868-8497
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/12014
dc.language.isoeng
dc.publisherSPRINGER
dc.relation.ispartofHormones & Cancer
dc.rightsrestrictedAccess
dc.rights.holderCopyright SPRINGER
dc.subject.othercomputed-tomography
dc.subject.otherf-18-fdg pet/ct
dc.subject.othercarcinoma
dc.subject.otherct
dc.subject.otherincidentalomas
dc.subject.othermalignancy
dc.subject.otheradenomas
dc.subject.otherrisk
dc.subject.wosOncology
dc.subject.wosEndocrinology & Metabolism
dc.titleRadiographic Characteristics of Adrenal Masses Preceding the Diagnosis of Adrenocortical Cancer
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryisous
hcfmusp.author.externalLIROV, R.:Univ Michigan, UMHS, Dept Surg, Ann Arbor, MI 48109 USA
hcfmusp.author.externalCAOILI, E. M.:Univ Michigan, UMHS, Dept Radiol, Ann Arbor, MI 48109 USA
hcfmusp.author.externalLERARIO, A. M.:Univ Michigan, UMHS, Dept Internal Med, Div Metab Endocrinol & Diabet MEND, Ann Arbor, MI 48109 USA
hcfmusp.author.externalMILLER, B. S.:Univ Michigan, UMHS, Sect Gen Surg, Div Endocrine Surg, Ann Arbor, MI 48109 USA
hcfmusp.author.externalDUNNICK, N. R.:Univ Michigan, UMHS, Dept Surg, Ann Arbor, MI 48109 USA; Univ Michigan, UMHS, Dept Radiol, Ann Arbor, MI 48109 USA
hcfmusp.author.externalHAMMER, G. D.:Univ Michigan, UMHS, Dept Internal Med, Div Metab Endocrinol & Diabet MEND, Ann Arbor, MI 48109 USA
hcfmusp.author.externalELSE, T.:Univ Michigan, UMHS, Dept Internal Med, Div Metab Endocrinol & Diabet MEND, Ann Arbor, MI 48109 USA
hcfmusp.citation.scopus22
hcfmusp.contributor.author-fmusphcTHIAGO MACHADO NOGUEIRA
hcfmusp.contributor.author-fmusphcMARIA CANDIDA BARISSON VILLARES FRAGOSO
hcfmusp.description.beginpage176
hcfmusp.description.endpage181
hcfmusp.description.issue4
hcfmusp.description.volume6
hcfmusp.origemWOS
hcfmusp.origem.pubmed26021762
hcfmusp.origem.scopus2-s2.0-84933678762
hcfmusp.origem.wosWOS:000357038500007
hcfmusp.publisher.cityNEW YORK
hcfmusp.publisher.countryUSA
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hcfmusp.scopus.lastupdate2024-05-10
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Artigos e Materiais de Revistas Científicas - LIM/42
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