Searching for the Immune Basis of Obsessive-Compulsive Disorder

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art_TEIXEIRA_Searching_for_the_Immune_Basis_of_ObsessiveCompulsive_Disorder_2014.PDF (170.93 KB)
Citações na Scopus
32
Tipo de produção
article
Data de publicação
2014
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
Autores
TEIXEIRA, Antonio Lucio
RODRIGUES, David Henrique
FONTENELLE, Leonardo F.
Citação
NEUROIMMUNOMODULATION, v.21, n.42431, p.152-158, 2014
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
The etiopathogenesis of obsessive-compulsive disorder (OCD) remains elusive. Clinical observation of the elevated frequency of obsessive-compulsive symptoms in patients with rheumatic fever, a post-streptococcal autoimmune disease, prompted the study of immune parameters in OCD. Anti-basal ganglia antibodies have been described in a subset of OCD patients. The assessment of circulating cytokines and immune cells confirmed unequivocal changes in at least some patients, although it is difficult to establish a particular immune profile in OCD. Several factors, including the use of psychotropic drugs and the presence of comorbid conditions, seem to influence these immune parameters. (C) 2014 S. Karger AG, Basel
Palavras-chave
Obsessive-compulsive disorder, Anti-basal ganglia antibodies, Rheumatic chorea
URI
https://observatorio.fm.usp.br/handle/OPI/15997
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MPS
Artigos e Materiais de Revistas Científicas - HC/IPq
Artigos e Materiais de Revistas Científicas - LIM/21