24-Week beta-alanine ingestion does not affect muscle taurine or clinical blood parameters in healthy males

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSAUNDERS, Bryan
dc.contributor.authorFRANCHI, Mariana
dc.contributor.authorOLIVEIRA, Luana Farias de
dc.contributor.authorSILVA, Vinicius da Eira
dc.contributor.authorSILVA, Rafael Pires da
dc.contributor.authorPAINELLI, Vitor de Salles
dc.contributor.authorCOSTA, Luiz Augusto Riani
dc.contributor.authorSALE, Craig
dc.contributor.authorHARRIS, Roger Charles
dc.contributor.authorROSCHEL, Hamilton
dc.contributor.authorARTIOLI, Guilherme Giannini
dc.contributor.authorGUALANO, Bruno
dc.date.accessioned2020-03-24T14:52:54Z
dc.date.available2020-03-24T14:52:54Z
dc.date.issued2020
dc.description.abstractPurpose To investigate the effects of chronic beta-alanine (BA) supplementation on muscle taurine content, blood clinical markers and sensory side-effects. Methods Twenty-five healthy male participants (age 27 +/- 4 years, height 1.75 +/- 0.09 m, body mass 78.9 +/- 11.7 kg) were supplemented with 6.4 g day(-1) of sustained-release BA (N = 16; CarnoSyn (TM), NAI, USA) or placebo (PL; N = 9; maltodextrin) for 24 weeks. Resting muscle biopsies of the m. vastus lateralis were taken at 0, 12 and 24 weeks and analysed for taurine content (BA, N = 12; PL, N = 6) using high-performance liquid chromatography. Resting venous blood samples were taken every 4 weeks and analysed for markers of renal, hepatic and muscle function (BA, N = 15; PL, N = 8; aspartate transaminase; alanine aminotransferase; alkaline phosphatase; lactate dehydrogenase; albumin; globulin; creatinine; estimated glomerular filtration rate and creatine kinase). Results There was a significant main effect of group (p = 0.04) on muscle taurine, with overall lower values in PL, although there was no main effect of time or interaction effect (both p > 0.05) and no differences between specific timepoints (week 0, BA: 33.67 +/- 8.18 mmol kg(-1) dm, PL: 27.75 +/- 4.86 mmol kg(-1) dm; week 12, BA: 35.93 +/- 8.79 mmol kg(-1) dm, PL: 27.67 +/- 4.75 mmol kg(-1) dm; week 24, BA: 35.42 +/- 6.16 mmol kg(-1) dm, PL: 31.99 +/- 5.60 mmol kg(-1) dm). There was no effect of treatment, time or any interaction effects on any blood marker (all p > 0.05) and no self-reported side-effects in these participants throughout the study. Conclusions The current study showed that 24 weeks of BA supplementation at 6.4 g day(-1) did not significantly affect muscle taurine content, clinical markers of renal, hepatic and muscle function, nor did it result in chronic sensory side-effects, in healthy individuals. Since athletes are likely to engage in chronic supplementation, these data provide important evidence to suggest that supplementation with BA at these doses for up to 24 weeks is safe for healthy individuals.eng
dc.description.indexMEDLINEeng
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao PauloFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2016/50438-0, 2017/04973-4, 2015/22686-7, 2013/04806-0, 2012/13026-5, 2014/11948-8, 2013/14746-4]
dc.description.sponsorshipCoordenacao de Aper-feicoamento de Pessoal de Nivel Superior-Brasil (CAPES) [001]
dc.description.sponsorshipNational Alternatives International (NAI), San Marcos, California
dc.identifier.citationEUROPEAN JOURNAL OF NUTRITION, v.59, n.1, p.57-65, 2020
dc.identifier.doi10.1007/s00394-018-1881-0
dc.identifier.eissn1436-6215
dc.identifier.issn1436-6207
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/35575
dc.language.isoeng
dc.publisherSPRINGER HEIDELBERGeng
dc.relation.ispartofEuropean Journal of Nutrition
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright SPRINGER HEIDELBERGeng
dc.subjectChronic beta-alanine supplementationeng
dc.subjectMuscle taurineeng
dc.subjectClinical markerseng
dc.subjectSafetyeng
dc.subjectSide-effectseng
dc.subject.otherskeletal-muscleeng
dc.subject.othercarnosine contenteng
dc.subject.otherindividual fiberseng
dc.subject.otherelderly subjectseng
dc.subject.othersupplementationeng
dc.subject.otherperformanceeng
dc.subject.otherexerciseeng
dc.subject.otherhistidineeng
dc.subject.othercapacityeng
dc.subject.otheranserineeng
dc.subject.wosNutrition & Dieteticseng
dc.title24-Week beta-alanine ingestion does not affect muscle taurine or clinical blood parameters in healthy maleseng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryInglaterra
hcfmusp.affiliation.countryisogb
hcfmusp.author.externalFRANCHI, Mariana:Univ Sao Paulo, Fac Med FMUSP, Sch Phys Educ & Sport, Appl Physiol & Nutr Res Grp,Rheumatol Div, Av Dr Arnaldo 455, BR-01246903 Sao Paulo, SP, Brazil
hcfmusp.author.externalSILVA, Vinicius da Eira:Univ Sao Paulo, Fac Med FMUSP, Sch Phys Educ & Sport, Appl Physiol & Nutr Res Grp,Rheumatol Div, Av Dr Arnaldo 455, BR-01246903 Sao Paulo, SP, Brazil
hcfmusp.author.externalPAINELLI, Vitor de Salles:Univ Sao Paulo, Fac Med FMUSP, Sch Phys Educ & Sport, Appl Physiol & Nutr Res Grp,Rheumatol Div, Av Dr Arnaldo 455, BR-01246903 Sao Paulo, SP, Brazil
hcfmusp.author.externalCOSTA, Luiz Augusto Riani:Univ Sao Paulo, Fac Med FMUSP, Sch Phys Educ & Sport, Appl Physiol & Nutr Res Grp,Rheumatol Div, Av Dr Arnaldo 455, BR-01246903 Sao Paulo, SP, Brazil
hcfmusp.author.externalSALE, Craig:Nottingham Trent Univ, Musculoskeletal Physiol Res Grp, Sport Hlth & Performance Enhancement Res Ctr, Nottingham, England
hcfmusp.author.externalHARRIS, Roger Charles:Junipa Ltd, Newmarket, Suffolk, England
hcfmusp.citation.scopus13
hcfmusp.contributor.author-fmusphcBRYAN SAUNDERS
hcfmusp.contributor.author-fmusphcLUANA FARIAS DE OLIVEIRA
hcfmusp.contributor.author-fmusphcRAFAEL PIRES DA SILVA
hcfmusp.contributor.author-fmusphcHAMILTON AUGUSTO ROSCHEL DA SILVA
hcfmusp.contributor.author-fmusphcGUILHERME GIANNINI ARTIOLI
hcfmusp.contributor.author-fmusphcBRUNO GUALANO
hcfmusp.description.beginpage57
hcfmusp.description.endpage65
hcfmusp.description.issue1
hcfmusp.description.volume59
hcfmusp.origemWOS
hcfmusp.origem.pubmed30552505
hcfmusp.origem.scopus2-s2.0-85058392528
hcfmusp.origem.wosWOS:000512078900005
hcfmusp.publisher.cityHEIDELBERGeng
hcfmusp.publisher.countryGERMANYeng
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