Features of 847 Childhood-Onset Systemic Lupus Erythematosus Patients in Three Age Groups at Diagnosis: A Brazilian Multicenter Study

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorGOMES, Roberta C.
dc.contributor.authorSILVA, Marco F.
dc.contributor.authorKOZU, Katia
dc.contributor.authorBONFA, Eloisa
dc.contributor.authorPEREIRA, Rosa M.
dc.contributor.authorTERRERI, Maria T.
dc.contributor.authorMAGALHAES, Claudia S.
dc.contributor.authorSACCHETTI, Silvana B.
dc.contributor.authorMARINI, Roberto
dc.contributor.authorFRAGA, Melissa
dc.contributor.authorCARVALHO, Luciana M.
dc.contributor.authorBARBOSA, Cassia M.
dc.contributor.authorCARNEIRO-SAMPAIO, Magda
dc.contributor.authorSILVA, Clovis A.
dc.date.accessioned2017-02-16T12:41:37Z
dc.date.available2017-02-16T12:41:37Z
dc.date.issued2016
dc.description.abstractObjectiveTo evaluate demographic data and clinical and laboratory features at disease diagnosis in 3 different age groups of childhood-onset systemic lupus erythematosus (SLE): group A, early-onset (<6 years); group B, school age (6 to <12 years); and group C, adolescent (12 to <18 years). MethodsThis was a Brazilian multicenter cohort retrospective study in 10 pediatric rheumatology centers, including 847 childhood-onset SLE patients. ResultsPatients were divided into 3 groups: group A with 39 patients (4%), group B with 395 patients (47%), and group C with 413 patients (49%). Of 39 childhood-onset SLE patients in group A, 3 (8%) were ages <2 years, 4 (10%) were 2 to <3 years, and 32 (82%) were 3 and <6 years. A total of 74 childhood-onset SLE patients were analyzed for C1q levels, and complete C1q deficiency was observed in 3 of 74 patients (4%), all in group A. Groups were similar regarding high frequencies of female sex, nephritis, neuropsychiatric involvement, Systemic Lupus Erythematosus Disease Activity Index 2000 score 8, autoantibody profile, elevated acute phase proteins, and low complement levels (P>0.05). However, the frequency of fever (78% versus 61% versus 47%; P<0.0001), hepatomegaly (42% versus 29% versus 14%; P<0.0001), splenomegaly (28% versus 12% versus 4%; P<0.0001), and discoid lupus (13% versus 4% versus 4%; P=0.020) was significantly higher in group A compared to groups B and C. The frequency of weight loss >2 kg (19% versus 28% versus 36%; P=0.017), photosensitivity (34% versus 41% versus 51%; P=0.006), leukopenia <4,000/mm(3) (14% versus 25% versus 30%; P=0.048), and lymphopenia <1,500/mm(3) (22% versus 41% versus 47%; P=0.011) was significantly lower in group A. ConclusionOur large multicenter study identified the finding that the initial appearance of childhood-onset SLE is characterized by comparable high frequency of internal organ involvement and some distinct clinical and laboratory features in early-onset and adolescent groups.
dc.description.indexMEDLINE
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico [CNPq 305068/2014-8, CNPq 301805/2013-0, CNPq 303422/2015-7-1A]
dc.description.sponsorshipFederico Foundation
dc.description.sponsorshipNucleo de Apoio a Pesquisa Saude da Crianca e do Adolescente da USP (grant NAP-CriAd)
dc.identifier.citationARTHRITIS CARE & RESEARCH, v.68, n.11, p.1736-1741, 2016
dc.identifier.doi10.1002/acr.22881
dc.identifier.eissn2151-4658
dc.identifier.issn2151-464X
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/17809
dc.language.isoeng
dc.publisherWILEY-BLACKWELL
dc.relation.ispartofArthritis Care & Research
dc.rightsrestrictedAccess
dc.rights.holderCopyright WILEY-BLACKWELL
dc.subject.otherclinical-features
dc.subject.othercriteria
dc.subject.otherchildren
dc.subject.othermanifestations
dc.subject.otheradolescents
dc.subject.wosRheumatology
dc.titleFeatures of 847 Childhood-Onset Systemic Lupus Erythematosus Patients in Three Age Groups at Diagnosis: A Brazilian Multicenter Study
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalTERRERI, Maria T.:Univ Fed Sao Paulo, Sao Paulo, Brazil
hcfmusp.author.externalMAGALHAES, Claudia S.:Sao Paulo State Univ UNESP, Sao Paulo, Brazil
hcfmusp.author.externalSACCHETTI, Silvana B.:Irmandade Santa Casa Misericordia Sao Paulo, Sao Paulo, Brazil
hcfmusp.author.externalMARINI, Roberto:State Univ Campinas UNICAMP, Sao Paulo, Brazil
hcfmusp.author.externalFRAGA, Melissa:Univ Fed Sao Paulo, Sao Paulo, Brazil
hcfmusp.author.externalCARVALHO, Luciana M.:Univ Sao Paulo, Sao Paulo, Brazil
hcfmusp.author.externalBARBOSA, Cassia M.:Hosp Infantil Darcy Vargas, Sao Paulo, Brazil
hcfmusp.citation.scopus52
hcfmusp.contributor.author-fmusphcROBERTA CUNHA GOMES
hcfmusp.contributor.author-fmusphcMARCO FELIPE CASTRO DA SILVA
hcfmusp.contributor.author-fmusphcKATIA TOMIE KOZU
hcfmusp.contributor.author-fmusphcELOISA SILVA DUTRA DE OLIVEIRA BONFA
hcfmusp.contributor.author-fmusphcROSA MARIA RODRIGUES PEREIRA
hcfmusp.contributor.author-fmusphcMAGDA MARIA SALES CARNEIRO SAMPAIO
hcfmusp.contributor.author-fmusphcCLOVIS ARTUR ALMEIDA DA SILVA
hcfmusp.description.beginpage1736
hcfmusp.description.endpage1741
hcfmusp.description.issue11
hcfmusp.description.volume68
hcfmusp.origemWOS
hcfmusp.origem.pubmed27014968
hcfmusp.origem.scopus2-s2.0-84983499302
hcfmusp.origem.wosWOS:000387058800021
hcfmusp.publisher.cityHOBOKEN
hcfmusp.publisher.countryUSA
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hcfmusp.scopus.lastupdate2024-05-10
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