Transcranial Direct Current Stimulation for Post-Concussion Syndrome: Study Protocol for a Randomized Crossover Trial
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Citações na Scopus
9
Tipo de produção
article
Data de publicação
2017
Título da Revista
ISSN da Revista
Título do Volume
Editora
FRONTIERS MEDIA SA
Citação
FRONTIERS IN NEUROLOGY, v.8, article ID 164, 8p, 2017
Resumo
Background: Mild traumatic brain injury (MTBI) represents 70-80% of all treated brain injuries. A considerable proportion of MTBI patients experience post-concussion symptoms for a prolonged period after MTBI, and these symptoms are diagnosed as persistent post-concussion syndrome (PPCS). PPCS is defined as a range of physical, cognitive, and emotional symptoms. However, memory and executive dysfunction seems to be one of the most debilitating symptoms. Recently, non-invasive brain stimulation has been studied as a potential treatment method for traumatic brain injury (TBI) patients. Therefore, our primary goal is to verify the effects of transcranial direct current stimulation (tDCS) in patients with PPCS who demonstrate cognitive deficits in long-term episodic memory, working memory, and executive function following MTBI. Methods/design: This is a randomized crossover trial of patients with a history of MTBI with cognitive deficits in memory and executive function. Thirty adult patients will be randomized in a crossover manner to receive three weekly sessions of anodal tDCS (2mA) at left dorsolateral prefrontal cortex, left temporal cortex, and sham stimulation that will be performed at 7-day intervals (washout period). The clinical diagnosis of PPCS will be determined using the Rivermead Post-Concussion Symptoms Questionnaire. Patients who meet the inclusion criteria will be assessed with a neuropsychological evaluation. A new battery of computerized neuropsychological tests will be performed before and immediately after each stimulation. Statistical analysis will be performed to determine trends of cognitive improvement. Discussion: There is paucity of studies regarding the use of tDCS in TBI patients, and although recent results showed controversial data regarding the effects of tDCS in such patients, we will address specifically patients with PPCS and MTBI and no brain abnormalities on CT scan other than subarachnoid hemorrhage. Moreover, due to the missing information on literature regarding the best brain region to be studied, we will evaluate two different regions to find immediate effects of tDCS on memory and executive dysfunction.
Palavras-chave
brain injuries, post-concussion syndrome, transcranial direct current stimulation, non-invasive brain stimulation, crossover studies
Referências
- Ahman S, 2013, J REHABIL MED, V45, P758, DOI 10.2340/16501977-1182
- Angelakis E, 2014, ARCH PHYS MED REHAB, V95, P283, DOI 10.1016/j.apmr.2013.09.002
- Bajaj JS, 2008, GASTROENTEROLOGY, V135, P1591, DOI 10.1053/j.gastro.2008.07.021
- BECK AT, 1961, ARCH GEN PSYCHIAT, V4, P561
- Benedict RHB, 1998, CLIN NEUROPSYCHOL, V12, P43, DOI 10.1076/clin.12.1.43.1726
- Bigler ED, 2001, ARCH CLIN NEUROPSYCH, V16, P95
- Bigler ED, 2008, J INT NEUROPSYCH SOC, V14, P1, DOI 10.1017/S135561770808017X
- Boggio PS, 2009, J NEUROL NEUROSUR PS, V80, P444, DOI 10.1136/jnnp.2007.141853
- Boggio PS, 2007, J AFFECT DISORDERS, V101, P91, DOI 10.1016/j.jad.2006.10.026
- Boggio PS, 2006, J NEUROL SCI, V249, P31, DOI 10.1016/j.jns.2006.05.062
- Boggio PS, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0004959
- Bolognini N, 2009, J NEUROENG REHABIL, V6, DOI 10.1186/1743-0003-6-8
- Bonni S, 2013, NEUROL SCI, V34, P2053, DOI 10.1007/s10072-013-1412-y
- Brandt J., 2001, HOPKINS VERBAL LEARN
- Brunoni AR, 2012, BRAIN STIMUL, V5, P175, DOI 10.1016/j.brs.2011.03.002
- Bueno VF, 2011, NEUROCASE, V17, P318, DOI 10.1080/13554794.2010.509319
- Cerruti C, 2009, J COGNITIVE NEUROSCI, V21, P1980, DOI 10.1162/jocn.2008.21143
- Cotelli M, 2014, FRONT AGING NEUROSCI, V6, DOI 10.3389/fnagi.2014.00038
- Datta SGS, 2009, NEUROL INDIA, V57, P594, DOI 10.4103/0028-3886.57810
- Lima DPD, 2008, INJURY, V39, P604, DOI 10.1016/j.injury.2007.11.008
- Demirtas-Tatlidede A, 2012, J HEAD TRAUMA REHAB, V27, P274, DOI 10.1097/HTR.0b013e318217df55
- Dockery CA, 2009, J NEUROSCI, V29, P7271, DOI 10.1523/JNEUROSCI.0065-09.2009
- Dresler M, 2013, NEUROPHARMACOLOGY, V64, P529, DOI 10.1016/j.neuropharm.2012.07.002
- Fecteau S, 2010, SUBST USE MISUSE, V45, P1766, DOI 10.3109/10826084.2010.482434
- Garavan H, 1999, P NATL ACAD SCI USA, V96, P8301, DOI 10.1073/pnas.96.14.8301
- Goldman RL, 2011, APPETITE, V56, P741, DOI 10.1016/j.appet.2011.02.013
- Gorenstein C, 1996, BRAZ J MED BIOL RES, V29, P453
- Harris PA, 2009, J BIOMED INFORM, V42, P377, DOI 10.1016/j.jbi.2008.08.010
- Howell D, 2013, MED SCI SPORT EXER, V45, P1030, DOI 10.1249/MSS.0b013e3182814595
- Iyer MB, 2005, NEUROLOGY, V64, P872
- Jo JM, 2009, AM J PHYS MED REHAB, V88, P404, DOI 10.1097/PHM.0b013e3181a0e4cb
- Jones KT, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0121904
- Kang EK, 2009, RESTOR NEUROL NEUROS, V27, P645, DOI 10.3233/RNN-2009-0514
- Kang EK, 2012, J REHABIL MED, V44, P346, DOI 10.2340/16501977-0947
- King N, 1997, BRIT J CLIN PSYCHOL, V36, P161
- KING NS, 1995, J NEUROL, V242, P587, DOI 10.1007/BF00868811
- Koski L, 2015, J NEUROTRAUM, V32, P38, DOI 10.1089/neu.2014.3449
- Lesniak M, 2014, J HEAD TRAUMA REHAB, V29, pE20, DOI 10.1097/HTR.0b013e318292a4c2
- Lezak M. D., 2012, NEUROPSYCHOLOGICAL A
- Rosenow J, 2009, BRAIN STIMUL, V2, P22, DOI 10.1016/J.BRS.2008.09.004
- Lundin A, 2006, BRAIN INJURY, V20, P799, DOI 10.1080/02699050600744327
- McCauley SR, 2001, J CLIN EXP NEUROPSYC, V23, P792, DOI 10.1076/jcen.23.6.792.1016
- Naunheim RS, 2008, J HEAD TRAUMA REHAB, V23, P116, DOI 10.1097/01.HTR.0000314530.30401.70
- Nitsche MA, 2008, BRAIN STIMUL, V1, P206, DOI 10.1016/j.brs.2008.06.004
- Park SH, 2013, J KOREAN NEUROSURG S, V54, P484, DOI 10.3340/jkns.2013.54.6.484
- Pereira JB, 2013, BRAIN STIMUL, V6, P16, DOI 10.1016/j.brs.2012.01.006
- Prigatano GP, 2011, CURR OPIN PSYCHIATR, V24, P243, DOI 10.1097/YCO.0b013e328344698b
- Riggio S, 2009, MT SINAI J MED, V76, P163, DOI 10.1002/msj.20097
- Rossi S, 2009, CLIN NEUROPHYSIOL, V120, P2008, DOI 10.1016/j.clinph.2009.08.016
- Ruffolo CF, 1999, ARCH PHYS MED REHAB, V80, P392, DOI 10.1016/S0003-9993(99)90275-7
- Son AHPWV, 2007, CLIN REHABIL, V21, P1024, DOI 10.1177/0269215507077603
- Spreen O, 1998, COMPENDIUM NEUROPSYC
- Stuart B, 2012, J EMERG NURS, V38, P435, DOI 10.1016/j.jen.2011.04.006
- Ulam F, 2015, CLIN NEUROPHYSIOL, V126, P486, DOI 10.1016/j.clinph.2014.05.015
- Van den Eynde F, 2010, BIOL PSYCHIAT, V67, P793, DOI 10.1016/j.biopsych.2009.11.023
- Vanderhasselt MA, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0062219
- Weschler D, 1997, WESCHLER ADULT INTEL
- Wu YJ, 2014, BRAIN COGNITION, V91, P87, DOI 10.1016/j.bandc.2014.09.002
- Yun GJ, 2015, J STROKE, V17, P354, DOI 10.5853/jos.2015.17.3.354
Coleções
Artigos e Materiais de Revistas Científicas - FM/MNE
Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/IPq
Artigos e Materiais de Revistas Científicas - LIM/26
Artigos e Materiais de Revistas Científicas - LIM/27
Carregar mais Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/IPq
Artigos e Materiais de Revistas Científicas - LIM/26
Artigos e Materiais de Revistas Científicas - LIM/27