Endoscopic findings in uninvestigated dyspepsia

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorFAINTUCH, Jacob Jehuda
dc.contributor.authorSILVA, Fernando Marcuz
dc.contributor.authorNAVARRO-RODRIGUEZ, Tomas
dc.contributor.authorBARBUTI, Ricardo Correa
dc.contributor.authorHASHIMOTO, Claudio Lyoiti
dc.contributor.authorROSSINI, Alessandra Rita Asayama Lopes
dc.contributor.authorDINIZ, Marcio Augusto
dc.contributor.authorEISIG, Jaime Natan
dc.date.accessioned2014-04-28T22:07:20Z
dc.date.available2014-04-28T22:07:20Z
dc.date.issued2014
dc.description.abstractBackground: It is important to know the causes of dyspepsia to establish the therapeutic approach. Dyspepsia is a frequent syndrome in our country, where there are restrictions to endoscopy and high prevalence of Helicobacter pylori (H. pylori) infection. This study aimed to assess the endoscopic findings of the syndrome, in an outpatient screening clinic of a tertiary hospital in Sao Paulo. Methods: Outpatients with uninvestigated dyspepsia, according to Rome III criteria, answered a dyspepsia questionnaire and underwent esophagogastroduodenoscopy. The Rapid Urease Test was applied to fragments of the antral mucosa and epidemiological data were collected from the studied population. Organic dyspepsia findings were analyzed with different variables to verify statistically significant associations. Results: Three hundred and six patients were included and 282 were analyzed in the study. The mean age was 44 years and women comprised 65% of the sample. Forty-five percent of the patients reported alarm symptoms. Functional dyspepsia was found in 66% of the patients (20% with normal endoscopy results and 46% with gastritis), 18% had GERD and 13% had ulcers (duodenal in 9% and gastric in 4%). Four cases of gastric adenocarcinoma were identified (1.4%), one without alarm characteristics, 1 case of adenocarcinoma of the distal esophagus and 1 case of gastric lymphoma. The prevalence of H. pylori was 54% and infection, age and smoking status were associated with organic dyspepsia. The age of 48 years was indicative of alarm signs. Conclusions: The endoscopic diagnosis of uninvestigated dyspepsia in our setting showed a predominance of functional disease, whereas cancer was an uncommon finding, despite the high prevalence of H. pylori. Organic dyspepsia was associated with infection, age and smoking status.
dc.description.indexMEDLINE
dc.identifier.citationBMC GASTROENTEROLOGY, v.14, article ID 19, 7p, 2014
dc.identifier.doi10.1186/1471-230X-14-19
dc.identifier.issn1471-230X
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/5483
dc.language.isoeng
dc.publisherBIOMED CENTRAL LTD
dc.relation.ispartofBMC Gastroenterology
dc.rightsopenAccess
dc.rights.holderCopyright BIOMED CENTRAL LTD
dc.subjectDyspepsia findings
dc.subjectEsophagitis
dc.subjectGastric cancer
dc.subjectPeptic ulcer
dc.subject.otherhelicobacter-pylori infection
dc.subject.otherupper gastrointestinal symptoms
dc.subject.otherpeptic-ulcer disease
dc.subject.otherfunctional dyspepsia
dc.subject.otherclinical-features
dc.subject.otherprimary-care
dc.subject.otherprevalence
dc.subject.otherpopulation
dc.subject.othermanagement
dc.subject.otherbrazil
dc.subject.wosGastroenterology & Hepatology
dc.titleEndoscopic findings in uninvestigated dyspepsia
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalDINIZ, Marcio Augusto:Univ Sao Paulo, Fac Med, Hosp Clin, Div Gastroenterol & Clin Hepatol, BR-09500900 Sao Paulo, Brazil
hcfmusp.citation.scopus21
hcfmusp.contributor.author-fmusphcJACOB JEHUDA FAINTUCH
hcfmusp.contributor.author-fmusphcFERNANDO MARCUZ SILVA
hcfmusp.contributor.author-fmusphcTOMAS NAVARRO RODRIGUEZ
hcfmusp.contributor.author-fmusphcRICARDO CORREA BARBUTI
hcfmusp.contributor.author-fmusphcCLAUDIO LYOITI HASHIMOTO
hcfmusp.contributor.author-fmusphcALESSANDRA RITA ASAYAMA LOPES ROSSINI
hcfmusp.contributor.author-fmusphcJAIME NATAN EISIG
hcfmusp.description.articlenumber19
hcfmusp.description.volume2014
hcfmusp.origemWOS
hcfmusp.origem.pubmed24499444
hcfmusp.origem.scopus2-s2.0-84893166847
hcfmusp.origem.wosWOS:000332031700001
hcfmusp.publisher.cityLONDON
hcfmusp.publisher.countryENGLAND
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