Survival results of 3,786 patients with stage I or II laryngeal squamous cell carcinoma: a propensity score-based study

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorCARVALHO, Genival Barbosa de
dc.contributor.authorKOHLER, Hugo Fontan
dc.contributor.authorLIRA, Renan Bezerra
dc.contributor.authorVARTANIAN, Jose Guilherme
dc.contributor.authorKOWALSKI, Luiz Paulo
dc.date.accessioned2022-08-12T17:00:12Z
dc.date.available2022-08-12T17:00:12Z
dc.date.issued2022
dc.description.abstractIntroduction Laryngeal squamous cell carcinoma is the second most prevalent malignancy among head and neck tumors, and the treatment of patients with stage I or II disease can be performed with surgery or radiation therapy. National population studies describing therapeutic results comparing these modalities are unusual, but they can be very important to direct treatment guidelines. Objective To evaluate the survival results of patients with laryngeal squamous cell carcinoma at clinical stages I or II, according to the main therapeutic modalities used. Methods Cross-sectional, population-based study using the database of Fundacao Oncocentro de Sao Paulo from January 2000 to March 2019. Inclusion criteria were patients with laryngeal squamous cell carcinoma in clinical stages cT1-2N0. To compensate for the non-random allocation of patients and the imbalance between confounding variables between groups, we used the propensity score methodology. Results A total of 3786 patients met the inclusion criteria. Regarding the cT stage, there were 2171 patients (57.3%) with cT1 tumors. Patients in the public health system had a longer time between diagnosis and treatment (p similar to <similar to 0.001). The analysis by propensity score showed that patients treated with surgery had a tendency towards better disease-specific survival (p similar to=similar to 0.012). Comparing radiotherapy alone versus its combination with radiochemotherapy, radiotherapy alone showed a tendency towards a better survival rate (p similar to <similar to 0.001). Conclusion Analysis by propensity score identified better results for disease-specific survival in patients with laryngeal squamous cell carcinoma at clinical stages I and II treated by surgery when compared to radiotherapy.eng
dc.description.indexMEDLINEeng
dc.identifier.citationBRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY, v.88, n.3, p.337-344, 2022
dc.identifier.doi10.1016/j.bjorl.2020.06.007
dc.identifier.eissn1808-8686
dc.identifier.issn1808-8694
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/48235
dc.language.isopor
dc.publisherASSOC BRASILEIRA OTORRINOLARINGOLOGIA & CIRURGIA CERVICOFACIALeng
dc.relation.ispartofBrazilian Journal of Otorhinolaryngology
dc.rightsopenAccesseng
dc.rights.holderCopyright ASSOC BRASILEIRA OTORRINOLARINGOLOGIA & CIRURGIA CERVICOFACIALeng
dc.subjectLaryngeal cancer, Surgery, Radiotherapy, Prognostic factorseng
dc.subject.otherearly glottic cancereng
dc.subject.otherradiotherapyeng
dc.subject.othersurgeryeng
dc.subject.otherchemotherapyeng
dc.subject.othermanagementeng
dc.subject.otherradiationeng
dc.subject.otherlasereng
dc.subject.wosOtorhinolaryngologyeng
dc.titleSurvival results of 3,786 patients with stage I or II laryngeal squamous cell carcinoma: a propensity score-based studyeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalCARVALHO, Genival Barbosa de:AC Camargo Canc Ctr, Dept Cirurgia Cabeca & Pescoco, Sao Paulo, SP, Brazil
hcfmusp.author.externalKOHLER, Hugo Fontan:AC Camargo Canc Ctr, Dept Cirurgia Cabeca & Pescoco, Sao Paulo, SP, Brazil
hcfmusp.author.externalLIRA, Renan Bezerra:AC Camargo Canc Ctr, Dept Cirurgia Cabeca & Pescoco, Sao Paulo, SP, Brazil
hcfmusp.author.externalVARTANIAN, Jose Guilherme:AC Camargo Canc Ctr, Dept Cirurgia Cabeca & Pescoco, Sao Paulo, SP, Brazil
hcfmusp.citation.scopus5
hcfmusp.contributor.author-fmusphcLUIZ PAULO KOWALSKI
hcfmusp.description.beginpage337
hcfmusp.description.endpage344
hcfmusp.description.issue3
hcfmusp.description.volume88
hcfmusp.origemWOS
hcfmusp.origem.pubmed32771434
hcfmusp.origem.scieloSCIELO:S1808-86942022000300337
hcfmusp.origem.scopus2-s2.0-85089136523
hcfmusp.origem.wosWOS:000810701200008
hcfmusp.publisher.citySAO PAULOeng
hcfmusp.publisher.countryBRAZILeng
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