Association of Sex Mismatch Between Donor and Recipient With Graft Survivorship at 5 Years After Osteochondral Allograft Transplantation

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorMERKELY, Gergo
dc.contributor.authorFARINA, Evan M.
dc.contributor.authorLEITE, Chilan B. G.
dc.contributor.authorACKERMANN, Jakob
dc.contributor.authorGORTZ, Simon
dc.contributor.authorLATTERMANN, Christian
dc.contributor.authorGOMOLL, Andreas H.
dc.date.accessioned2022-06-20T15:32:21Z
dc.date.available2022-06-20T15:32:21Z
dc.date.issued2022
dc.description.abstractBackground: Sex mismatch between donor and recipient has been considered a potential contributor to adverse outcomes after solid organ transplantation. However, the influence of sex mismatching in osteochondral allograft (OCA) transplantation has yet to be determined. Purpose: To evaluate whether donor-recipient sex mismatching affects graft survival after OCA transplantation. Study Design: Cohort study; Level of evidence, 3. Methods: In this review of prospectively collected data, patients who underwent OCA transplantation between November 2013 and November 2017 by a single surgeon were analyzed. Cumulative survival was assessed via the Kaplan-Meier method using log-rank tests to compare patients with similar donor groups. Multivariable Cox regression analysis adjusted for patient age, graft size, and body mass index was used to evaluate the influence of donor-recipient sex on graft survival. Results: A total of 154 patients were included: 102 (66.2%) who received OCAs from a same-sex donor and 52 (33.8%) who received OCAs from a different-sex donor. At 5-year follow-up, a significantly lower graft survival rate was observed for different-sex donor transplantation in comparison with same-sex donorship (63% vs 92%; P = .01). When correcting for age, graft size, and body mass index, donor-recipient sex-mismatch transplantation demonstrated a 2.9-times greater likelihood to fail at 5 years compared with donor-recipient same-sex transplantation (95% CI, 1.11-7.44; P = .03). A subgroup analysis showed no significant difference in graft survival between the female-to-female and female-to-male groups (91% and 84%, respectively). Conversely, male-to-male transplantation demonstrated a significantly higher cumulative 5-year survival (94%; P = .04), whereas lower survival was found with male-to-female donorship (64%; P = .04). Multivariable Cox regression indicated a 2.6-times higher likelihood of failure for the male-to-female group in comparison with the other groups (95% CI, 1.03-6.69; P = .04). Male-to-male transplantation had a tendency toward decreased likelihood of OCA failure (hazard ratio, 0.33), although without statistical significance (95% CI, 0.11-1.01; P = .052). Conclusion: Mismatch between donor and recipient sex had a negative effect on OCA survival after transplantation, particularly in those cases when male donor tissue was transplanted into a female recipient.eng
dc.description.indexMEDLINEeng
dc.description.sponsorshipJRF Ortho
dc.description.sponsorshipKairos Surgical
dc.description.sponsorshipVericel
dc.description.sponsorshipGoode Surgical Inc
dc.description.sponsorshipArthrex
dc.identifier.citationAMERICAN JOURNAL OF SPORTS MEDICINE, v.50, n.3, p.681-688, 2022
dc.identifier.doi10.1177/03635465211068872
dc.identifier.eissn1552-3365
dc.identifier.issn0363-5465
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/47264
dc.language.isoeng
dc.publisherSAGE PUBLICATIONS INCeng
dc.relation.ispartofAmerican Journal of Sports Medicine
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright SAGE PUBLICATIONS INCeng
dc.subjectosteochondral allografteng
dc.subjectsex mismatcheng
dc.subjectarticular cartilageeng
dc.subject.otherminor histocompatibility antigeneng
dc.subject.otherfemale immune-responseeng
dc.subject.otherlung-transplantationeng
dc.subject.otherarticular-cartilageeng
dc.subject.otherkneeeng
dc.subject.othergendereng
dc.subject.otheroutcomeseng
dc.subject.otherfailureeng
dc.subject.otherboneeng
dc.subject.otherimmunogenicityeng
dc.subject.wosGeriatrics & Gerontologyeng
dc.titleAssociation of Sex Mismatch Between Donor and Recipient With Graft Survivorship at 5 Years After Osteochondral Allograft Transplantationeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countrySuíça
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryisous
hcfmusp.affiliation.countryisoch
hcfmusp.author.externalMERKELY, Gergo:Harvard Med Sch, Brigham & Womens Hosp, Cartilage Repair Ctr, 75 Francis St, Boston, MA 02115 USA
hcfmusp.author.externalFARINA, Evan M.:Harvard Med Sch, Brigham & Womens Hosp, Cartilage Repair Ctr, 75 Francis St, Boston, MA 02115 USA
hcfmusp.author.externalACKERMANN, Jakob:Univ Zurich, Balgrist Univ Hosp, Dept Orthoped, Zurich, Switzerland
hcfmusp.author.externalGORTZ, Simon:Harvard Med Sch, Brigham & Womens Hosp, Cartilage Repair Ctr, 75 Francis St, Boston, MA 02115 USA
hcfmusp.author.externalLATTERMANN, Christian:Harvard Med Sch, Brigham & Womens Hosp, Cartilage Repair Ctr, 75 Francis St, Boston, MA 02115 USA
hcfmusp.author.externalGOMOLL, Andreas H.:Hosp Special Surg, 535 E 70th St, New York, NY 10021 USA
hcfmusp.citation.scopus7
hcfmusp.contributor.author-fmusphcCHILAN BOU GHOSSON LEITE
hcfmusp.description.articlenumber3635465211068870
hcfmusp.description.beginpage681
hcfmusp.description.endpage688
hcfmusp.description.issue3
hcfmusp.description.volume50
hcfmusp.origemWOS
hcfmusp.origem.pubmed35044257
hcfmusp.origem.scopus2-s2.0-85123491734
hcfmusp.origem.wosWOS:000748968700001
hcfmusp.publisher.cityTHOUSAND OAKSeng
hcfmusp.publisher.countryUSAeng
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