Creatine Supplementation Associated or Not with Strength Training upon Emotional and Cognitive Measures in Older Women: A Randomized Double-Blind Study

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorALVES, Christiano Robles Rodrigues
dc.contributor.authorMEREGE FILHO, Carlos Alberto Abujabra
dc.contributor.authorBENATTI, Fabiana Braga
dc.contributor.authorBRUCKI, Sonia
dc.contributor.authorPEREIRA, Rosa Maria R.
dc.contributor.authorPINTO, Ana Lucia de Sa
dc.contributor.authorLIMA, Fernanda Rodrigues
dc.contributor.authorROSCHEL, Hamilton
dc.contributor.authorGUALANO, Bruno
dc.date.accessioned2014-01-28T22:17:15Z
dc.date.available2014-01-28T22:17:15Z
dc.date.issued2013
dc.description.abstractPurpose: To assess the effects of creatine supplementation, associated or not with strength training, upon emotional and cognitive measures in older woman. Methods: This is a 24-week, parallel-group, double-blind, randomized, placebo-controlled trial. The individuals were randomly allocated into one of the following groups (n=14 each): 1) placebo, 2) creatine supplementation, 3) placebo associated with strength training or 4) creatine supplementation associated with strength training. According to their allocation, the participants were given creatine (4 x 5 g/d for 5 days followed by 5 g/d) or placebo (dextrose at the same dosage) and were strength trained or not. Cognitive function, assessed by a comprehensive battery of tests involving memory, selective attention, and inhibitory control, and emotional measures, assessed by the Geriatric Depression Scale, were evaluated at baseline, after 12 and 24 weeks of the intervention. Muscle strength and food intake were evaluated at baseline and after 24 weeks. Results: After the 24-week intervention, both training groups (ingesting creatine supplementation and placebo) had significant reductions on the Geriatric Depression Scale scores when compared with the non-trained placebo group (p = 0.001 and p = 0.01, respectively) and the non-trained creatine group (p < 0.001 for both comparison). However, no significant differences were observed between the non-trained placebo and creatine (p = 0.60) groups, or between the trained placebo and creatine groups (p = 0.83). Both trained groups, irrespective of creatine supplementation, had better muscle strength performance than the non-trained groups. Neither strength training nor creatine supplementation altered any parameter of cognitive performance. Food intake remained unchanged. Conclusion: Creatine supplementation did not promote any significant change in cognitive function and emotional parameters in apparently healthy older individuals. In addition, strength training per se improved emotional state and muscle strength, but not cognition, with no additive effects of creatine supplementation.
dc.description.indexMEDLINE
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
dc.identifier.citationPLOS ONE, v.8, n.10, article ID e76301, 10p, 2013
dc.identifier.doi10.1371/journal.pone.0076301
dc.identifier.issn1932-6203
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/3889
dc.language.isoeng
dc.publisherPUBLIC LIBRARY SCIENCE
dc.relation.ispartofPlos One
dc.rightsopenAccess
dc.rights.holderCopyright PUBLIC LIBRARY SCIENCE
dc.subject.othermagnetic-resonance-spectroscopy
dc.subject.othermajor depressive disorder
dc.subject.othermini-mental-state
dc.subject.otherphysical-activity
dc.subject.otherhuman brain
dc.subject.otherantidepressant treatment
dc.subject.otheroral supplementation
dc.subject.otherresistance exercise
dc.subject.othermood disorders
dc.subject.othermonohydrate
dc.subject.wosMultidisciplinary Sciences
dc.titleCreatine Supplementation Associated or Not with Strength Training upon Emotional and Cognitive Measures in Older Women: A Randomized Double-Blind Study
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalALVES, Christiano Robles Rodrigues:Univ Sao Paulo, Sch Phys Educ & Sport, Sao Paulo, Brazil
hcfmusp.author.externalROSCHEL, Hamilton:Univ Sao Paulo, Sch Phys Educ & Sport, Sao Paulo, Brazil; Univ Sao Paulo, Sch Med, Sao Paulo, Brazil
hcfmusp.citation.scopus49
hcfmusp.contributor.author-fmusphcCARLOS ALBERTO ABUJABRA MEREGE FILHO
hcfmusp.contributor.author-fmusphcFABIANA BRAGA BENATTI
hcfmusp.contributor.author-fmusphcSONIA MARIA DOZZI BRUCKI
hcfmusp.contributor.author-fmusphcROSA MARIA RODRIGUES PEREIRA
hcfmusp.contributor.author-fmusphcANA LUCIA DE SA PINTO
hcfmusp.contributor.author-fmusphcFERNANDA RODRIGUES LIMA
hcfmusp.contributor.author-fmusphcBRUNO GUALANO
hcfmusp.description.articlenumbere76301
hcfmusp.description.issue10
hcfmusp.description.volume8
hcfmusp.origemWOS
hcfmusp.origem.pubmed24098469
hcfmusp.origem.scopus2-s2.0-84884861033
hcfmusp.origem.wosWOS:000325483600037
hcfmusp.publisher.citySAN FRANCISCO
hcfmusp.publisher.countryUSA
hcfmusp.relation.referenceAGREN H, 1988, J NEURAL TRANSM, V74, P55, DOI 10.1007/BF01243575
hcfmusp.relation.referenceAlmeida OP, 1999, ARQ NEURO-PSIQUIAT, V57, P421, DOI 10.1590/S0004-282X1999000300013
hcfmusp.relation.referenceAmital D, 2006, J CLIN PSYCHIAT, V67, P836
hcfmusp.relation.referenceAndres RH, 2008, BRAIN RES BULL, V76, P329, DOI 10.1016/j.brainresbull.2008.02.035
hcfmusp.relation.referenceArbuthnott K, 2000, J CLIN EXP NEUROPSYC, V22, P518, DOI 10.1076/1380-3395(200008)22:4;1-0;FT518
hcfmusp.relation.referenceBENTON D, 2010, BJ NUTR, V105, P1
hcfmusp.relation.referenceBrucki SMD, 2003, ARQ NEURO-PSIQUIAT, V61, P777, DOI 10.1590/S0004-282X2003000500014
hcfmusp.relation.referenceBurroughs S, 2007, CURR ANAESTH CRIT CA, V18, P34, DOI [10.1016/j.cacc.2007.01.007, DOI 10.1016/J.CACC.2007.01.007]
hcfmusp.relation.referenceCassilhas RC, 2007, MED SCI SPORT EXER, V39, P1401, DOI 10.1249/mss.0b013e318060111f
hcfmusp.relation.referenceCassilhas RC, 2010, PERCEPT MOTOR SKILL, V110, P265, DOI 10.2466/PMS.110.1.265-276
hcfmusp.relation.referenceColcombe S, 2003, PSYCHOL SCI, V14, P125, DOI 10.1111/1467-9280.t01-1-01430
hcfmusp.relation.referenceCRONHOLM B, 1956, Nord Med, V56, P1612
hcfmusp.relation.referenceCzeh B, 2001, P NATL ACAD SCI USA, V98, P12796, DOI 10.1073/pnas.211427898
hcfmusp.relation.referenceDechent P, 1999, AM J PHYSIOL-REG I, V277, pR698
hcfmusp.relation.referenceDechent P, 1999, BIOL PSYCHIAT, V46, P406, DOI 10.1016/S0006-3223(98)00346-1
hcfmusp.relation.referenceDuman RS, 1999, BIOL PSYCHIAT, V46, P1181, DOI 10.1016/S0006-3223(99)00177-8
hcfmusp.relation.referenceEtnier JL, 2006, BRAIN RES REV, V52, P119, DOI 10.1016/j.brainresrev.2006.01.002
hcfmusp.relation.referenceFOLSTEIN MF, 1975, J PSYCHIAT RES, V12, P189, DOI 10.1016/0022-3956(75)90026-6
hcfmusp.relation.referenceGabbay V, 2007, AM J PSYCHIAT, V164, P1881, DOI 10.1176/appi.ajp.2007.06122032
hcfmusp.relation.referenceHeyn P, 2004, ARCH PHYS MED REHAB, V85, P1694, DOI 10.1016/j.apmr.2004.03.019
hcfmusp.relation.referenceHillman CH, 2008, NAT REV NEUROSCI, V9, P58, DOI 10.1038/nrn2298
hcfmusp.relation.referenceIosifescu DV, 2008, BIOL PSYCHIAT, V63, P1127, DOI 10.1016/j.biopsych.2007.11.020
hcfmusp.relation.referenceKaldis P, 1996, DEV NEUROSCI-BASEL, V18, P542, DOI 10.1159/000111452
hcfmusp.relation.referenceKalia M, 2005, METABOLISM, V54, P24, DOI 10.1016/j.metabol.2005.01.009
hcfmusp.relation.referenceKATO T, 1994, J AFFECT DISORDERS, V31, P125, DOI 10.1016/0165-0327(94)90116-3
hcfmusp.relation.referenceLarson EB, 2006, ANN INTERN MED, V144, P73
hcfmusp.relation.referenceLautenschlager NT, 2008, JAMA-J AM MED ASSOC, V300, P1027, DOI 10.1001/jama.300.9.1027
hcfmusp.relation.referenceLiu-Ambrose T, 2010, ARCH INTERN MED, V170, P170, DOI 10.1001/archinternmed.2009.494
hcfmusp.relation.referenceLyoo IK, 2003, PSYCHIAT RES-NEUROIM, V123, P87, DOI 10.1016/S0925-4927(03)00046-5
hcfmusp.relation.referenceManji HK, 2000, MOL PSYCHIATR, V5, P578, DOI 10.1038/sj.mp.4000811
hcfmusp.relation.referenceManji HK, 2001, NAT MED, V7, P541, DOI 10.1038/87865
hcfmusp.relation.referenceMcEwen BS, 2005, METABOLISM, V54, P20, DOI 10.1016/j.metabol.2005.01.008
hcfmusp.relation.referenceMcMorris T, 2007, PHYSIOL BEHAV, V90, P21, DOI 10.1016/j.physbeh.2006.08.024
hcfmusp.relation.referenceMcMorris T, 2007, AGING NEUROPSYCHOL C, V14, P517, DOI 10.1080/13825580600788100
hcfmusp.relation.referenceMoore CM, 1997, AM J PSYCHIAT, V154, P116
hcfmusp.relation.referenceMoretti A, 2003, MOL PSYCHIATR, V8, P773, DOI 10.1038/sj.mp.4001353
hcfmusp.relation.referenceNitrini R, 2004, J INT NEUROPSYCH SOC, V10, P634, DOI 10.1017/S1355617704104062
hcfmusp.relation.referenceParkin AJ, 1999, NEUROPSYCHOLOGY, V13, P539, DOI 10.1037//0894-4105.13.4.539
hcfmusp.relation.referencePerrig-Chiello P, 1998, AGE AGEING, V27, P469, DOI 10.1093/ageing/27.4.469
hcfmusp.relation.referenceRae C, 2003, P ROY SOC B-BIOL SCI, V270, P2147, DOI 10.1098/rspb.2003.2492
hcfmusp.relation.referenceRawson ES, 2011, AMINO ACIDS, V40, P1349, DOI 10.1007/s00726-011-0855-9
hcfmusp.relation.referenceRoitman S, 2007, BIPOLAR DISORD, V9, P754, DOI 10.1111/j.1399-5618.2007.00532.x
hcfmusp.relation.referenceSalomons GS, 2003, J INHERIT METAB DIS, V26, P309, DOI 10.1023/A:1024405821638
hcfmusp.relation.referenceSofi F, 2011, J INTERN MED, V269, P107, DOI 10.1111/j.1365-2796.2010.02281.x
hcfmusp.relation.referenceSPIRDUSO WW, 1975, J GERONTOL, V30, P435
hcfmusp.relation.referenceSpreen O, 1998, COMPENDIUM NEUROPSYC
hcfmusp.relation.referenceStockler S, 1996, LANCET, V348, P789, DOI 10.1016/S0140-6736(96)04116-5
hcfmusp.relation.referencevan Gool CH, 2003, AGE AGEING, V32, P81, DOI 10.1093/ageing/32.1.81
hcfmusp.relation.referencevan Gool CH, 2007, AM J PUBLIC HEALTH, V97, P887, DOI 10.2105/AJPH.2004.053199
hcfmusp.relation.referenceWatanabe A, 2002, NEUROSCI RES, V42, P279, DOI 10.1016/S0168-0102(02)00007-X
hcfmusp.relation.referenceWyss M, 2000, PHYSIOL REV, V80, P1107
hcfmusp.remissive.sponsorshipCNPq
hcfmusp.remissive.sponsorshipFAPESP
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