Differential Diagnosis of AKI in Clinical Practice by Functional and Damage Biomarkers: Workgroup Statements from the Tenth Acute Dialysis Quality Initiative Consensus Conference

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorENDRE, Zoltan H.
dc.contributor.authorKELLUM, John A.
dc.contributor.authorSOMMA, Salvatore Di
dc.contributor.authorDOI, Kent
dc.contributor.authorGOLDSTEIN, Stuart L.
dc.contributor.authorKOYNER, Jay L.
dc.contributor.authorMACEDO, Etienne
dc.contributor.authorMEHTA, Ravindra L.
dc.contributor.authorMURRAY, Patrick T.
dc.contributor.groupauthorADQI 10 Workgrp
dc.date.accessioned2013-09-23T16:50:40Z
dc.date.available2013-09-23T16:50:40Z
dc.date.issued2013
dc.description.abstractAcute kidney injury (AKI) is a common but complex clinical syndrome with multiple etiologies. These etiologies target different sites and pathways within the kidney. Novel biomarkers of 'kidney damage' (which can be tubular or glomerular) can be used to diagnose AKI, even in the absence of an increase in serum creatinine or oliguria. These biomarkers of kidney damage can be combined with biomarkers of kidney function to facilitate classification of AKI. A comprehensive review of the literature was performed using the published methodology of the Acute Dialysis Quality Initiative (ADQI) working group and used to establish consensus statements regarding the use of biomarkers in the differential diagnosis of AKI. We recommend that the pathophysiological terms 'functional change' and 'kidney damage' be used in preference to the anatomical classification using the terms pre-renal, renal and post-renal AKI. We further recommend the use of both renal and non-renal biomarkers in establishing the specific cause of AKI as soon as possible after diagnosis. The presence of underlying CKD or of sepsis poses additional challenges in differential diagnosis, since these conditions alter both baseline biomarker excretion and biomarker performance. We recommend that biomarkers be validated within the clinical context in which they are to be used. Within that context, combinations of biomarkers may, in the future, allow differentiation of the site, mechanism and phase of injury.
dc.description.conferencedateAUG 30-SEP 01, 2011
dc.description.conferencelocalDublin, IRELAND
dc.description.conferencename10th Acute Dialysis Quality Initiative Consensus Conference
dc.description.indexMEDLINE
dc.description.sponsorshipNIDDK NIH HHS
dc.identifier.citationADQI CONSENSUS ON AKI BIOMARKERS AND CARDIORENAL SYNDROMES, v.182, p.30-44, 2013
dc.identifier.doi10.1159/000349964
dc.identifier.isbn978-3-318-02406-7
dc.identifier.issn0302-5144
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/2295
dc.language.isoeng
dc.publisherKARGER
dc.relation.ispartofAdqi Consensus on Aki Biomarkers and Cardiorenal Syndromes
dc.rightsrestrictedAccess
dc.rights.holderCopyright KARGER
dc.subject.otheracute kidney injury
dc.subject.othergelatinase-associated lipocalin
dc.subject.othercritically-ill patients
dc.subject.otheracute-renal-failure
dc.subject.otherintensive-care-unit
dc.subject.otherlong-term survival
dc.subject.otherreplacement therapy
dc.subject.otherurinary biomarkers
dc.subject.othercardiac-surgery
dc.subject.otherrisk stratification
dc.subject.wosUrology & Nephrology
dc.titleDifferential Diagnosis of AKI in Clinical Practice by Functional and Damage Biomarkers: Workgroup Statements from the Tenth Acute Dialysis Quality Initiative Consensus Conference
dc.typearticle
dc.type.categoryarticle; proceedings paper
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.affiliation.countryIrlanda
hcfmusp.affiliation.countryJapão
hcfmusp.affiliation.countryItália
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryNova Zelândia
hcfmusp.affiliation.countryisonz
hcfmusp.affiliation.countryisous
hcfmusp.affiliation.countryisoit
hcfmusp.affiliation.countryisojp
hcfmusp.affiliation.countryisoie
hcfmusp.author.externalENDRE, Zoltan H.:Univ New S Wales, Prince Wales Clin Sch, Dept Nephrol, Sydney, NSW, Australia; Univ Otago, Dept Med, Christchurch Kidney Res Grp, Christchurch, New Zealand
hcfmusp.author.externalKELLUM, John A.:Univ Pittsburgh, Sch Med, Dept Crit Care Med, Pittsburgh, PA USA
hcfmusp.author.externalSOMMA, Salvatore Di:Univ Roma La Sapienza, Dept Med & Surg Sci & Translat Med, Rome, Italy
hcfmusp.author.externalDOI, Kent:Univ Tokyo, Dept Emergency & Crit Care Med, Tokyo, Japan
hcfmusp.author.externalGOLDSTEIN, Stuart L.:Cincinnati Childrens Hosp, Med Ctr, Ctr Acute Care Nephrol, Cincinnati, OH USA
hcfmusp.author.externalKOYNER, Jay L.:Univ Chicago, Pritzker Sch Med, Nephrol Sect, Chicago, IL 60637 USA
hcfmusp.author.externalMEHTA, Ravindra L.:Univ Calif San Diego, UCSD Med Ctr, San Diego, CA 92103 USA
hcfmusp.author.externalMURRAY, Patrick T.:Univ Coll Dublin, Sch Med & Med Sci, Dublin 2, Ireland
hcfmusp.citation.scopus105
hcfmusp.contributor.author-fmusphcETIENNE MARIA VASCONCELLOS DE MACEDO
hcfmusp.description.beginpage30
hcfmusp.description.endpage44
hcfmusp.description.volume182
hcfmusp.origemWOS
hcfmusp.origem.pubmed23689654
hcfmusp.origem.scopus2-s2.0-84879097629
hcfmusp.origem.wosWOS:000321800100004
hcfmusp.publisher.cityBASEL
hcfmusp.publisher.countrySWITZERLAND
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