Molecular characterization of the Hepatitis B virus genotypes in Colombia: A Bayesian inference on the genotype F

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorMORA, Monica Viviana Alvarado
dc.contributor.authorROMANO, Camila Malta
dc.contributor.authorGOMES-GOUVEA, Michele Soares
dc.contributor.authorGUTIERREZ, Maria Fernanda
dc.contributor.authorBOTELHO, Livia
dc.contributor.authorCARRILHO, Flair Jose
dc.contributor.authorPINHO, Joao Renato Rebello
dc.date.accessioned2017-11-27T16:27:15Z
dc.date.available2017-11-27T16:27:15Z
dc.date.issued2011
dc.description.abstractHepatitis B is a worldwide health problem affecting about 2 billion people and more than 350 million are chronic carriers of the virus. Nine HBV genotypes (A to I) have been described. The geographical distribution of HBV genotypes is not completely understood due to the limited number of samples from some parts of the world. One such example is Colombia, in which few studies have described the HBV genotypes. In this study, we characterized HBV genotypes in 143 HBsAg-positive volunteer blood donors from Colombia. A fragment of 1306 bp partially comprising HBsAg and the DNA polymerase coding regions (S/POL) was amplified and sequenced. Bayesian phylogenetic analyses were conducted using the Markov Chain Monte Carlo (MCMC) approach to obtain the maximum clade credibility (MCC) tree using BEAST v.1.5.3. Of all samples, 68 were positive and 52 were successfully sequenced. Genotype F was the most prevalent in this population (77%) - subgenotypes F3 (75%) and Fib (2%). Genotype G (7.7%) and subgenotype A2 (15.3%) were also found. Genotype G sequence analysis suggests distinct introductions of this genotype in the country. Furthermore, we estimated the time of the most recent common ancestor (TMRCA) for each HBV/F subgenotype and also for Colombian F3 sequences using two different datasets: (i) 77 sequences comprising 1306 bp of S/POL region and (ii) 283 sequences comprising 681 bp of S/POL region. We also used two other previously estimated evolutionary rates: (i) 2.60 x 10(-4) s/s/y and (ii) 1.5 x 10(-5) s/s/y. Here we report the HBV genotypes circulating in Colombia and estimated the TMRCA for the four different subgenotypes of genotype F.
dc.description.indexMEDLINE
dc.description.sponsorshipCNPq
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo - FAPESP [2007/53457-7, 2008/50461-6]
dc.description.sponsorshipPontificia Universidad Javeriana, Bogota, Colombia
dc.identifier.citationINFECTION GENETICS AND EVOLUTION, v.11, n.1, p.103-108, 2011
dc.identifier.doi10.1016/j.meegid.2010.10.003
dc.identifier.issn1567-1348
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/23036
dc.language.isoeng
dc.publisherELSEVIER SCIENCE BV
dc.relation.ispartofInfection Genetics and Evolution
dc.rightsrestrictedAccess
dc.rights.holderCopyright ELSEVIER SCIENCE BV
dc.subjectHepatitis B virus
dc.subjectGenotype G
dc.subjectGenotype A2
dc.subjectGenotype F
dc.subjectBayesian analysis
dc.subjectColombia
dc.subject.otherhepatocellular-carcinoma
dc.subject.otherphylogenetic analysis
dc.subject.othergenetic diversity
dc.subject.othercomplete genomes
dc.subject.otherhbv genotype
dc.subject.otherwest-africa
dc.subject.otherepidemiology
dc.subject.othersubgenotype
dc.subject.othersequences
dc.subject.othersubtypes
dc.subject.wosInfectious Diseases
dc.titleMolecular characterization of the Hepatitis B virus genotypes in Colombia: A Bayesian inference on the genotype F
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.affiliation.countryColômbia
hcfmusp.affiliation.countryisoco
hcfmusp.author.externalGUTIERREZ, Maria Fernanda:Pontificia Javeriana Univ, Dept Microbiol, Virol Lab, Bogota, Colombia
hcfmusp.author.externalBOTELHO, Livia:Univ Sao Paulo, Lab Gastroenterol & Hepatol, Sao Paulo Inst Trop Med, Sch Med, Sao Paulo, Brazil
hcfmusp.citation.scopus44
hcfmusp.contributor.author-fmusphcMONICA VIVIANA ALVARADO MORA
hcfmusp.contributor.author-fmusphcCAMILA MALTA ROMANO
hcfmusp.contributor.author-fmusphcMICHELE SOARES GOMES GOUVEA
hcfmusp.contributor.author-fmusphcFLAIR JOSE CARRILHO
hcfmusp.contributor.author-fmusphcJOAO RENATO REBELLO PINHO
hcfmusp.description.beginpage103
hcfmusp.description.endpage108
hcfmusp.description.issue1
hcfmusp.description.volume11
hcfmusp.origemWOS
hcfmusp.origem.pubmed20951841
hcfmusp.origem.scopus2-s2.0-78650211577
hcfmusp.origem.wosWOS:000286558800014
hcfmusp.publisher.cityAMSTERDAM
hcfmusp.publisher.countryNETHERLANDS
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